MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover

[1]  D. Pei.  Identification and Characterization of the Fifth Membrane-type Matrix Metalloproteinase MT5-MMP* , 1999, The Journal of Biological Chemistry.

[2]  P. Delmas,et al.  The Collagenolytic Activity of Cathepsin K Is Unique among Mammalian Proteinases* , 1998, The Journal of Biological Chemistry.

[3]  Sheila J. Jones,et al.  Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[4]  S. Weiss,et al.  Matrix Metalloproteinases Regulate Neovascularization by Acting as Pericellular Fibrinolysins , 1998, Cell.

[5]  H. Nagase.  Cell surface activation of progelatinase A (proMMP-2) and cell migration , 1998, Cell Research.

[6]  H. Birkedal‐Hansen,et al.  Dissolution of type I collagen fibrils by gingival fibroblasts isolated from patients of various periodontitis categories. , 1998, Journal of periodontal research.

[7]  Y. Suzuki,et al.  Osteoclast-like cells in murine collagen induced arthritis. , 1998, The Journal of rheumatology.

[8]  Gabriele Bergers,et al.  MMP-9/Gelatinase B Is a Key Regulator of Growth Plate Angiogenesis and Apoptosis of Hypertrophic Chondrocytes , 1998, Cell.

[9]  C. López-Otín,et al.  Induction of matrix metalloproteinase activation cascades based on membrane-type 1 matrix metalloproteinase: associated activation of gelatinase A, gelatinase B and collagenase 3. , 1998, The Biochemical journal.

[10]  T. Thornhill,et al.  Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis. , 1998, The American journal of pathology.

[11]  J. Foidart,et al.  In Vivo Evidence That the Stromelysin-3 Metalloproteinase Contributes in a Paracrine Manner to Epithelial Cell Malignancy , 1998, The Journal of cell biology.

[12]  Z. Werb.  ECM and Cell Surface Proteolysis: Regulating Cellular Ecology , 1997, Cell.

[13]  D. Beier,et al.  The Matrix Metalloproteinase-14 (MMP-14) Gene Is Structurally Distinct from Other MMP Genes and Is Co-expressed with the TIMP-2 Gene during Mouse Embryogenesis* , 1997, The Journal of Biological Chemistry.

[14]  S. Itohara,et al.  Unaltered Secretion of β-Amyloid Precursor Protein in Gelatinase A (Matrix Metalloproteinase 2)-deficient Mice* , 1997, The Journal of Biological Chemistry.

[15]  J. Weidner,et al.  Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints. , 1997, The Journal of clinical investigation.

[16]  S. Mundlos,et al.  Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development , 1997, Cell.

[17]  G. Karsenty,et al.  Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation , 1997, Cell.

[18]  C. López-Otín,et al.  Collagenase-3 (MMP-13) is expressed during human fetal ossification and re-expressed in postnatal bone remodeling and in rheumatoid arthritis. , 1997, Laboratory investigation; a journal of technical methods and pathology.

[19]  D. Rowe,et al.  Bone formation in vivo: comparison of osteogenesis by transplanted mouse and human marrow stromal fibroblasts. , 1997, Transplantation.

[20]  Z. Werb,et al.  Matrix metalloproteinases regulate morphogenesis, migration and remodeling of epithelium, tongue skeletal muscle and cartilage in the mandibular arch. , 1997, Development.

[21]  P. Basset,et al.  Expression of Matrix Metalloproteinases during Rat Skin Wound Healing: Evidence that Membrane Type-1 Matrix Metalloproteinase Is a Stromal Activator of Pro-Gelatinase A , 1997, The Journal of cell biology.

[22]  B. Hogan,et al.  Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[23]  Y. Okada,et al.  Membrane Type 1 Matrix Metalloproteinase Digests Interstitial Collagens and Other Extracellular Matrix Macromolecules* , 1997, The Journal of Biological Chemistry.

[24]  S. Kuznetsov,et al.  Species Differences in Growth Requirements for Bone Marrow Stromal Fibroblast Colony Formation In Vitro , 1996, Calcified Tissue International.

[25]  H. Sato,et al.  Activation of a recombinant membrane type 1‐matrix metalloproteinase (MT1‐MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)‐2 , 1996, FEBS letters.

[26]  Y. Okada,et al.  MT-MMP, the cell surface activator of proMMP-2 (pro-gelatinase A), is expressed with its substrate in mouse tissue during embryogenesis. , 1996, Journal of cell science.

[27]  Z. Werb,et al.  Extracellular matrix remodeling and the regulation of epithelial-stromal interactions during differentiation and involution. , 1996, Kidney international. Supplement.

[28]  T. Ley,et al.  Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[29]  X. Puente,et al.  Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma. , 1996, Cancer research.

[30]  Hiroshi Sato,et al.  Identification of the Second Membrane-type Matrix Metalloproteinase (MT-MMP-2) Gene from a Human Placenta cDNA Library , 1995, The Journal of Biological Chemistry.

[31]  B. Hinzmann,et al.  cDNA sequence and mRNA tissue distribution of a novel human matrix metalloproteinase with a potential transmembrane segment. , 1995, European journal of biochemistry.

[32]  E. Wagner,et al.  Expression of interstitial collagenase during skeletal development of the mouse is restricted to osteoblast-like cells and hypertrophic chondrocytes. , 1995, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[33]  A. Strongin,et al.  Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase , 1995, The Journal of Biological Chemistry.

[34]  B. Vandenbunder,et al.  Expression of interstitial collagenase is restricted to skeletal tissue during mouse embryogenesis. , 1995, Journal of cell science.

[35]  P. Libby,et al.  Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[36]  Motoharu Seiki,et al.  A matrix metalloproteinase expressed on the surface of invasive tumour cells , 1994, Nature.

[37]  J. Mcwhir,et al.  A new mouse embryonic stem cell line with good germ line contribution and gene targeting frequency. , 1992, Nucleic acids research.

[38]  P. Laird,et al.  A pgk::hprt fusion as a selectable marker for targeting of genes in mouse embryonic stem cells: disruption of the T-cell receptor delta-chain-encoding gene. , 1991, Gene.

[39]  L. Liotta,et al.  Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation , 1991, Cell.

[40]  A. Cole,et al.  Perivascular cells in cartilage canals of the developing mouse epiphysis. , 1985, The American journal of anatomy.

[41]  A. H. Melcher,et al.  Phagocytosis and digestion of collagen by gingival fibroblasts in vivo: a study of serial sections. , 1981, Journal of ultrastructure research.

[42]  J. Stadler,et al.  Pugnose-a recessive mutation in linkage group 3 of mice. , 1961 .

[43]  R. Johnson,et al.  Multiple calvarial defects in lmx1b mutant mice. , 1998, Developmental genetics.

[44]  J. Mudgett,et al.  Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destruction. , 1998, Arthritis and rheumatism.

[45]  Nagasehideaki.  Cell surface activation of progelatinase A （proMMP—2） and cell migration , 1998 .

[46]  D. Rifkin,et al.  Plasminogen activators and matrix metalloproteinases in angiogenesis. , 1996, Enzyme & protein.

[47]  H. Birkedal‐Hansen.  Proteolytic remodeling of extracellular matrix. , 1995, Current opinion in cell biology.

[48]  L. Liotta,et al.  Tumor cell interactions with the extracellular matrix during invasion and metastasis. , 1993, Annual review of cell biology.

[49]  H. Birkedal‐Hansen,et al.  Matrix metalloproteinases: a review. , 1993, Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists.

[50]  E. Bonucci,et al.  Basic and 'special' stains for plastic sections in bone marrow histopathology, with special reference to May-Grünwald Giemsa and enzyme histochemistry. , 1984, Basic and applied histochemistry.

[51]  B. Pauli,et al.  10 – Vascularity of Cartilage* , 1983 .

[52]  Lutfi Am.  Mode of growth, fate and functions of cartilage canals. , 1970 .