Heritable components of the human fecal microbiome are associated with visceral fat

[1]  T. Spector,et al.  Heritable components of the human fecal microbiome are associated with visceral fat , 2016, Genome Biology.

[2]  S. Simpson,et al.  Integrative Physiology: At the Crossroads of Nutrition, Microbiota, Animal Physiology, and Human Health. , 2017, Cell metabolism.

[3]  T. Spector,et al.  A heritability-based comparison of methods used to cluster 16S rRNA gene sequences into operational taxonomic units , 2016, PeerJ.

[4]  Emily R. Davenport,et al.  Genetic Determinants of the Gut Microbiome in UK Twins. , 2016, Cell host & microbe.

[5]  J. Raes,et al.  Population-level analysis of gut microbiome variation , 2016, Science.

[6]  Morris A. Swertz,et al.  Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity , 2016, Science.

[7]  H. Weiner,et al.  The Host Shapes the Gut Microbiota via Fecal MicroRNA. , 2016, Cell host & microbe.

[8]  S. Pettersson,et al.  Helicobacter pylori and gut microbiota modulate energy homeostasis prior to inducing histopathological changes in mice , 2016, Gut microbes.

[9]  Tim D Spector,et al.  Proton pump inhibitors alter the composition of the gut microbiota , 2015, Gut.

[10]  William A. Walters,et al.  Improved Bacterial 16S rRNA Gene (V4 and V4-5) and Fungal Internal Transcribed Spacer Marker Gene Primers for Microbial Community Surveys , 2015, mSystems.

[11]  Sarah L. Westcott,et al.  De novo clustering methods outperform reference-based methods for assigning 16S rRNA gene sequences to operational taxonomic units , 2015, PeerJ.

[12]  J. Štšepetova,et al.  New insights into the impact of Lactobacillus population on host-bacteria metabolic interplay , 2015, Oncotarget.

[13]  S. Bordenstein,et al.  Rethinking heritability of the microbiome , 2015, Science.

[14]  F. Levenez,et al.  Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology , 2015, Gut.

[15]  Jeroen Raes,et al.  Stool consistency is strongly associated with gut microbiota richness and composition, enterotypes and bacterial growth rates , 2015, Gut.

[16]  Ross M. Fraser,et al.  Genetic studies of body mass index yield new insights for obesity biology , 2015, Nature.

[17]  Jeroen Raes,et al.  How informative is the mouse for human gut microbiota research? , 2015, Disease Models & Mechanisms.

[18]  Tamara S. Roman,et al.  New genetic loci link adipose and insulin biology to body fat distribution , 2014, Nature.

[19]  Austin G. Davis-Richardson,et al.  Early Childhood Gut Microbiomes Show Strong Geographic Differences Among Subjects at High Risk for Type 1 Diabetes , 2014, Diabetes Care.

[20]  H. Daniel,et al.  Glyoxylate, a New Marker Metabolite of Type 2 Diabetes , 2014, Journal of diabetes research.

[21]  R. Knight,et al.  Meta‐analyses of human gut microbes associated with obesity and IBD , 2014, FEBS letters.

[22]  Angela C. Poole,et al.  Human Genetics Shape the Gut Microbiome , 2014, Cell.

[23]  Rob Knight,et al.  The Earth Microbiome project: successes and aspirations , 2014, BMC Biology.

[24]  D. Bates,et al.  Fitting Linear Mixed-Effects Models Using lme4 , 2014, 1406.5823.

[25]  E. Murphy,et al.  Exercise and associated dietary extremes impact on gut microbial diversity , 2014, Gut.

[26]  Timothy J. Laurent,et al.  A Taxonomic Signature of Obesity in the Microbiome? Getting to the Guts of the Matter , 2014, PloS one.

[27]  C. Bouchard,et al.  Findings from the Quebec Family Study on the Etiology of Obesity: Genetics and Environmental Highlights , 2014, Current Obesity Reports.

[28]  Mark I. McCarthy,et al.  Global analysis of DNA methylation variation in adipose tissue from twins reveals links to disease-associated variants in distal regulatory elements. , 2013, American journal of human genetics.

[29]  R. Knight,et al.  Meta-analyses of studies of the human microbiota , 2013, Genome research.

[30]  P. Bork,et al.  Richness of human gut microbiome correlates with metabolic markers , 2013, Nature.

[31]  Lucie Geurts,et al.  Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity , 2013, Proceedings of the National Academy of Sciences.

[32]  Ellen T. Gelfand,et al.  The Genotype-Tissue Expression (GTEx) project , 2013, Nature Genetics.

[33]  H. Goossens,et al.  Differences in gut microbiota composition between obese and lean children: a cross-sectional study , 2013, Gut Pathogens.

[34]  T. Spector,et al.  The relationship between DXA-based and anthropometric measures of visceral fat and morbidity in women , 2013, BMC Cardiovascular Disorders.

[35]  B. Stecher,et al.  'Blooming' in the gut: how dysbiosis might contribute to pathogen evolution , 2013, Nature Reviews Microbiology.

[36]  Alireza Moayyeri,et al.  COHORT PROFILE Cohort Profile : TwinsUK and Healthy Ageing Twin Study , 2013 .

[37]  Francesco Marabita,et al.  A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data , 2012, Bioinform..

[38]  Hélène Touzet,et al.  SortMeRNA: fast and accurate filtering of ribosomal RNAs in metatranscriptomic data , 2012, Bioinform..

[39]  T. Spector,et al.  Effects of age on genetic influence on bone loss over 17 years in women: The Healthy Ageing Twin Study (HATS) , 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[40]  R. Knight,et al.  Diversity, stability and resilience of the human gut microbiota , 2012, Nature.

[41]  J. Després,et al.  Body Fat Distribution and Risk of Cardiovascular Disease: An Update , 2012, Circulation.

[42]  Simon C. Potter,et al.  Mapping cis- and trans-regulatory effects across multiple tissues in twins , 2012, Nature Genetics.

[43]  E. Gamazon,et al.  The regulatory effect of miRNAs is a heritable genetic trait in humans , 2012, BMC Genomics.

[44]  D. Sinderen,et al.  Gut microbiota composition correlates with diet and health in the elderly , 2012, Nature.

[45]  D. Raoult,et al.  Comparative meta-analysis of the effect of Lactobacillus species on weight gain in humans and animals. , 2012, Microbial pathogenesis.

[46]  A. Macpherson,et al.  Interactions Between the Microbiota and the Immune System , 2012, Science.

[47]  M. Stephens,et al.  Genome-wide Efficient Mixed Model Analysis for Association Studies , 2012, Nature Genetics.

[48]  Katherine H. Huang,et al.  Structure, Function and Diversity of the Healthy Human Microbiome , 2012, Nature.

[49]  Anton J. Enright,et al.  Extent, Causes, and Consequences of Small RNA Expression Variation in Human Adipose Tissue , 2012, PLoS genetics.

[50]  R. Knight,et al.  Responses of Gut Microbiota to Diet Composition and Weight Loss in Lean and Obese Mice , 2012, Obesity.

[51]  William A. Walters,et al.  Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms , 2012, The ISME Journal.

[52]  David L. Ergun,et al.  Dual-Energy X-Ray Absorptiometry for Quantification of Visceral Fat , 2012, Obesity.

[53]  Eric P. Nawrocki,et al.  An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea , 2011, The ISME Journal.

[54]  Andrey A. Shabalin,et al.  Matrix eQTL: ultra fast eQTL analysis via large matrix operations , 2011, Bioinform..

[55]  H. Tamemoto,et al.  Association of subcutaneous and visceral fat mass with serum concentrations of adipokines in subjects with type 2 diabetes mellitus. , 2012, Endocrine journal.

[56]  J. Sung,et al.  Comparison of the Gut Microbiotas of Healthy Adult Twins Living in South Korea and the United States , 2011, Applied and Environmental Microbiology.

[57]  R. Reimer,et al.  Prebiotic fibres dose-dependently increase satiety hormones and alter Bacteroidetes and Firmicutes in lean and obese JCR:LA-cp rats , 2011, British Journal of Nutrition.

[58]  M. Zimmermann,et al.  The metabolic activity of gut microbiota in obese children is increased compared with normal-weight children and exhibits more exhaustive substrate utilization , 2011, Nutrition & Diabetes.

[59]  Arthur Kaser,et al.  Gut microbiome, obesity, and metabolic dysfunction. , 2011, The Journal of clinical investigation.

[60]  Ashraf Shoeib,et al.  Frequency of Firmicutes and Bacteroidetes in gut microbiota in obese and normal weight Egyptian children and adults , 2011, Archives of medical science : AMS.

[61]  P. Bork,et al.  Enterotypes of the human gut microbiome , 2011, Nature.

[62]  Peer Bork,et al.  Interactive Tree Of Life v2: online annotation and display of phylogenetic trees made easy , 2011, Nucleic Acids Res..

[63]  John Fox,et al.  OpenMx: An Open Source Extended Structural Equation Modeling Framework , 2011, Psychometrika.

[64]  Jesse R. Zaneveld,et al.  Pan-genome of the dominant human gut-associated archaeon, Methanobrevibacter smithii, studied in twins , 2011, Proceedings of the National Academy of Sciences.

[65]  Min Zhang,et al.  Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors , 2010, Proceedings of the National Academy of Sciences.

[66]  E. Murphy,et al.  Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models , 2010, Gut.

[67]  Robert C. Edgar,et al.  BIOINFORMATICS APPLICATIONS NOTE , 2001 .

[68]  C. Jobin,et al.  High-Fat Diet: Bacteria Interactions Promote Intestinal Inflammation Which Precedes and Correlates with Obesity and Insulin Resistance in Mouse , 2010, PloS one.

[69]  Tsun-Po Yang,et al.  Genevar: a database and Java application for the analysis and visualization of SNP-gene associations in eQTL studies , 2010, Bioinform..

[70]  Wolfgang Viechtbauer,et al.  Conducting Meta-Analyses in R with the metafor Package , 2010 .

[71]  K. Imaizumi,et al.  Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial , 2010, European Journal of Clinical Nutrition.

[72]  J. Faith,et al.  Dissecting the in Vivo Metabolic Potential of Two Human Gut Acetogens , 2010, The Journal of Biological Chemistry.

[73]  Ming D. Li,et al.  Genome-wide meta-analyses identify multiple loci associated with smoking behavior , 2010, Nature Genetics.

[74]  William A. Walters,et al.  QIIME allows analysis of high-throughput community sequencing data , 2010, Nature Methods.

[75]  R. Ley,et al.  Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5 , 2010, Science.

[76]  Robert G. Beiko,et al.  Identifying biologically relevant differences between metagenomic communities , 2010, Bioinform..

[77]  Youfang Cao,et al.  Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice , 2010, The ISME Journal.

[78]  F. Bushman,et al.  QIIME allows integration and analysis of high-throughput community sequencing data. Nat. Meth. , 2010 .

[79]  Skipper Seabold,et al.  Statsmodels: Econometric and Statistical Modeling with Python , 2010, SciPy.

[80]  R. Knight,et al.  The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice , 2009, Science Translational Medicine.

[81]  Fabrice Armougom,et al.  Monitoring Bacterial Community of Human Gut Microbiota Reveals an Increase in Lactobacillus in Obese Patients and Methanogens in Anorexic Patients , 2009, PloS one.

[82]  P. Donnelly,et al.  A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies , 2009, PLoS genetics.

[83]  James Versalovic,et al.  Targeting the human microbiome with antibiotics, probiotics, and prebiotics: gastroenterology enters the metagenomics era. , 2009, Gastroenterology.

[84]  B. Roe,et al.  A core gut microbiome in obese and lean twins , 2008, Nature.

[85]  S. O’Rahilly,et al.  Human Obesity: A Heritable Neurobehavioral Disorder That Is Highly Sensitive to Environmental Conditions , 2008, Diabetes.

[86]  A. Uitterlinden,et al.  Sex-specific genetic effects influence variation in body composition , 2008, Diabetologia.

[87]  J. Doré,et al.  Molecular analysis of the digestive microbiota in a gnotobiotic mouse model during antibiotic treatment: Influence of Saccharomyces boulardii. , 2008, Anaerobe.

[88]  Rustam I. Aminov,et al.  Predominant Role of Host Genetics in Controlling the Composition of Gut Microbiota , 2008, PloS one.

[89]  R. Knight,et al.  Evolution of Mammals and Their Gut Microbes , 2008, Science.

[90]  L. Fulton,et al.  Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. , 2008, Cell host & microbe.

[91]  V. Somers,et al.  Accuracy of body mass index in diagnosing obesity in the adult general population , 2008, International Journal of Obesity.

[92]  J. Wardle,et al.  Genetic and environmental determinants of children's food preferences , 2008, British Journal of Nutrition.

[93]  J. Opitz,et al.  Obesity: Genetic, molecular, and environmental aspects , 2007, American journal of medical genetics. Part A.

[94]  T. Spector,et al.  Dietary Patterns and Heritability of Food Choice in a UK Female Twin Cohort , 2007, Twin Research and Human Genetics.

[95]  T. Spector,et al.  Linkage of genes to total lean body mass in normal women. , 2007, Journal of Clinical Endocrinology and Metabolism.

[96]  Udo Hoffmann,et al.  Abdominal Visceral and Subcutaneous Adipose Tissue Compartments: Association With Metabolic Risk Factors in the Framingham Heart Study , 2007, Circulation.

[97]  Philipp E. Scherer,et al.  Visceral Fat Adipokine Secretion Is Associated With Systemic Inflammation in Obese Humans , 2007, Diabetes.

[98]  Jiang He,et al.  Genetic epidemiology of obesity. , 2007, Epidemiologic reviews.

[99]  P. Turnbaugh,et al.  Microbial ecology: Human gut microbes associated with obesity , 2006, Nature.

[100]  E. Mardis,et al.  An obesity-associated gut microbiome with increased capacity for energy harvest , 2006, Nature.

[101]  C. Block,et al.  Mechanisms linking obesity with cardiovascular disease , 2006, Nature.

[102]  Eugene V Koonin,et al.  Evolution of glyoxylate cycle enzymes in Metazoa: evidence of multiple horizontal transfer events and pseudogene formation , 2006, Biology Direct.

[103]  Paul Poirier,et al.  Obesity and Cardiovascular Disease: Pathophysiology, Evaluation, and Effect of Weight Loss: An Update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease From the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism , 2006, Circulation.

[104]  Y. Pekarsky,et al.  A mouse model of the fragile gene FHIT: From carcinogenesis to gene therapy and cancer prevention. , 2005, Mutation research.

[105]  F. Bäckhed,et al.  Obesity alters gut microbial ecology. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[106]  Michel Galinier,et al.  Uncomplicated human obesity is associated with a specific cardiac transcriptome: involvement of the Wnt pathway , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[107]  Johan Trygg,et al.  The PLS method -- partial least squares projections to latent structures -- and its applications in industrial RDP (research, development, and production) , 2004 .

[108]  J. Cauley,et al.  The prediction of visceral fat by dual-energy X-ray absorptiometry in the elderly: a comparison with computed tomography and anthropometry , 2002, International Journal of Obesity.

[109]  S. Thompson,et al.  Quantifying heterogeneity in a meta‐analysis , 2002, Statistics in medicine.

[110]  J. Gordon,et al.  How host-microbial interactions shape the nutrient environment of the mammalian intestine. , 2002, Annual review of nutrition.

[111]  Willem M. de Vos,et al.  The Host Genotype Affects the Bacterial Community in the Human Gastrointestinal Tract , 2001 .

[112]  B. Wajchenberg Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. , 2000, Endocrine reviews.

[113]  S. Song Can the glyoxylate pathway contribute to fat-induced hepatic insulin resistance? , 2000, Medical hypotheses.

[114]  E. Bertin,et al.  Measurement of visceral adipose tissue by DXA combined with anthropometry in obese humans , 2000, International Journal of Obesity.

[115]  C. Bouchard,et al.  Familial resemblance for body composition measures: the HERITAGE Family Study. , 1997, Obesity research.

[116]  J. Després,et al.  Segregation analysis of abdominal visceral fat: the HERITAGE Family Study. , 1997, Obesity research.

[117]  M. Neale,et al.  Genetic and Environmental Factors in Relative Body Weight and Human Adiposity , 1997, Behavior genetics.

[118]  T. Spector,et al.  Independent genetic factors determine the amount and distribution of fat in women after the menopause. , 1997, The Journal of clinical endocrinology and metabolism.

[119]  J. Kaprio,et al.  The heritability of body mass index among an international sample of monozygotic twins reared apart. , 1996, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

[120]  C. Croce,et al.  The FHIT Gene, Spanning the Chromosome 3p14.2 Fragile Site and Renal Carcinoma–Associated t(3;8) Breakpoint, Is Abnormal in Digestive Tract Cancers , 1996, Cell.

[121]  Y. Matsuzawa,et al.  Visceral fat accumulation and cardiovascular disease. , 1995, Obesity research.

[122]  Y. Benjamini,et al.  Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .

[123]  L. Bartoshuk,et al.  Children's food preferences and genetic sensitivity to the bitter taste of 6-n-propylthiouracil (PROP). , 1991, The American journal of clinical nutrition.

[124]  J. Mayer,et al.  Studies of pyruvate and acetate metabolism in the hereditary obesity-diabetes syndrome of mice. , 1952, The Journal of biological chemistry.