Prevalence of dysphagia in patients with multiple sclerosis: A systematic review and meta-analysis

Objectives: Dysphagia is a major comorbidity observed in patients with multiple sclerosis, yet different prevalence rates are reported for it. Therefore, we have designed this systematic review to estimate the pooled prevalence of dysphagia in patients with MS. Method: We searched PubMed, Scopus, EMBASE, Web of Science, and gray literature including references from the identified studies, reviews studies, and conference abstracts which were published up to February 2021. Articles that were relevant to our topic and could provide information regarding the prevalence of dysphagia among MS patients were included; however, articles with self-report screening strategies were excluded. Results: The literature search found 1993 articles. After eliminating duplicates, 1272 articles remained. Sixteen abstract conference papers were included for final analysis. A total of 10846 MS cases and 4913 MS patients with dysphagia included in the analysis. The pooled prevalence of dysphagia in the included studies was 45.3% (95% CI: [40.7%-50%]) Conclusion: The results of this systematic review shows that the prevalence of dysphagia in MS patients is 45% which is greatly higher compared to the general population.

[1]  S. Eskandarieh,et al.  Global assessment of characteristics of multiple sclerosis registries; A systematic review. , 2022, Multiple sclerosis and related disorders.

[2]  V. Shaygannejad,et al.  Prevalence of multiple sclerosis (MS) in Iran: a systematic review and meta-analysis , 2021, Neurological Sciences.

[3]  Tuba Maden,et al.  Myotonometric comparison of sternocleidomastoideus and masseter muscles in multiple sclerosis patients with swallowing problem and healthy individuals. , 2021, Multiple sclerosis and related disorders.

[4]  M. Roganović,et al.  Screening of dysphagia in relapsing-remitting multiple sclerosis patients in Montenegro , 2021, Neurosciences.

[5]  A. Demir,et al.  The relationship between dysphagia, respiratory functions and anthropometry in patients with multiple sclerosis. , 2021, Multiple sclerosis and related disorders.

[6]  M. Noroozi,et al.  Depression, Anxiety, and Stress Relative to Swallowing Impairment in Persons with Multiple Sclerosis , 2021, Dysphagia.

[7]  V. Shaygannejad,et al.  Prevalence and Risk Factors of Dysphagia in Patients with Multiple Sclerosis , 2021, Dysphagia.

[8]  V. Shaygannejad,et al.  Prevalence of Seizure/Epilepsy in Patients with Multiple Sclerosis: A Systematic Review and Meta-Analysis , 2021, International journal of preventive medicine.

[9]  V. Shaygannejad,et al.  The prevalence of migraine in multiple sclerosis (MS): A systematic review and meta-analysis , 2020, Journal of Clinical Neuroscience.

[10]  E. Kavaz,et al.  Screening of dysphagia by DYMUS (Dysphagia in multiple sclerosis) and SWALQoL (Swallowing quality of life) surveys in patients with multiple sclerosis. , 2020, Multiple sclerosis and related disorders.

[11]  A. Ebadi,et al.  Swallowing Disorder in Multiple Sclerosis: Modified Version of the Screening Tool , 2020 .

[12]  G. Ruoppolo,et al.  Multiple Sclerosis: Impact on Oral Hygiene, Dysphagia, and Quality of Life , 2020, International journal of environmental research and public health.

[13]  R. Bergamaschi,et al.  The Dysphagia in Multiple Sclerosis Questionnaire Correlates with Fiber-Optic Endoscopic Examination for Detecting Swallowing Deficits in MS , 2020, Dysphagia.

[14]  N. N. Ansari,et al.  Dysphagia In Multiple Sclerosis Patients: Diagnostic And Evaluation Strategies , 2020, Degenerative neurological and neuromuscular disease.

[15]  N. Grigoriadis,et al.  The modified DYMUS questionnaire is a reliable, valid and easy‐to‐use tool in the assessment of dysphagia in multiple sclerosis , 2020, European journal of neurology.

[16]  L. Hartelius,et al.  Self-Reported Changes in Cognition, Communication and Swallowing in Multiple Sclerosis: Data from the Swedish Multiple Sclerosis Registry and from a National Survey , 2020, Folia Phoniatrica et Logopaedica.

[17]  R. Bergamaschi,et al.  Prevalence of dysphagia in a consecutive cohort of subjects with MS using fibre-optic endoscopy , 2019, Neurological Sciences.

[18]  H. J. Silva,et al.  Electrical activity of the masseter and supra hyoid muscles during swallowing of patients with multiple sclerosis. , 2019, CoDAS.

[19]  J. Constantinidis,et al.  Dysphagia Prevalence, Attitudes, and Related Quality of Life in Patients with Multiple Sclerosis , 2019, Dysphagia.

[20]  M. Milewska,et al.  The prevalence and types of oral- and pharyngeal-stage dysphagia in patients with demyelinating diseases based on subjective assessment by the study subjects. , 2019, Multiple sclerosis and related disorders.

[21]  C. Tufanaru,et al.  Methodological quality of case series studies: an introduction to the JBI critical appraisal tool , 2019, JBI database of systematic reviews and implementation reports.

[22]  N. Fathy,et al.  Depicting Neurogenic Dysphagia in a Sample of Egyptian Multiple Sclerosis Patients , 2018, Multiple Sclerosis and Related Disorders.

[23]  Leila Ghelichi,et al.  Prevalence of dysphagia in multiple sclerosis and its related factors: Systematic review and meta-analysis , 2018, Iranian journal of neurology.

[24]  K. Ballard,et al.  The frequency of dysphagia and its impact on adults with multiple sclerosis based on patient-reported questionnaires. , 2018, Multiple sclerosis and related disorders.

[25]  Z. Jafari,et al.  Validation of the Persian version of dysphagia in multiple sclerosis questionnaire for the assessment of dysphagia in multiple sclerosis , 2018, Iranian journal of neurology.

[26]  V. D. Groot,et al.  Validation of DYMUS-NL for swallowing function in MS , 2018 .

[27]  N. N. Ansari,et al.  Prevalence and predictors of dysphagia in Iranian patients with multiple sclerosis , 2017, Medical journal of the Islamic Republic of Iran.

[28]  N. Moradi,et al.  Diagnostic evaluation of dysphagia in multiple sclerosis patients using a Persian version of DYMUS questionnaire. , 2017, Multiple sclerosis and related disorders.

[29]  Y. Fragoso,et al.  Orofacial evaluation in patients with multiple sclerosis using Nordic Orofacial Test-Screening , 2017, Clinical Oral Investigations.

[30]  C. Açikel,et al.  Validity and Reliability of the Turkish Version of the Questionnaire for the Assessment of Dysphagia in Multiple Sclerosis. , 2016, Noro psikiyatri arsivi.

[31]  Kirrie Ballard,et al.  Treatment Effects for Dysphagia in Adults with Multiple Sclerosis: A Systematic Review , 2016, Dysphagia.

[32]  Y. Seçil,et al.  Electrophysiological Evaluation of Dysphagia in the Mild or Moderate Patients with Multiple Sclerosis: A Concept of Subclinical Dysphagia , 2015, Dysphagia.

[33]  Haishan Huang,et al.  Prevalence of dysphagia in multiple sclerosis: a systematic review and meta-analysis , 2015, Neurological Sciences.

[34]  J. Vietri,et al.  Symptoms and Association with Health Outcomes in Relapsing-Remitting Multiple Sclerosis: Results of a US Patient Survey , 2014, Multiple sclerosis international.

[35]  Mark Loeb,et al.  Newcastle-Ottawa Scale: comparing reviewers’ to authors’ assessments , 2014, BMC Medical Research Methodology.

[36]  P. Giraux,et al.  Screening and typology of dysphagia in multiple sclerosis , 2013 .

[37]  D. Levinthal,et al.  Adding to the Burden: Gastrointestinal Symptoms and Syndromes in Multiple Sclerosis , 2013, Multiple sclerosis international.

[38]  A. Ghezzi,et al.  Prevalence of patient-reported dysphagia in multiple sclerosis patients: An Italian multicenter study (using the DYMUS questionnaire) , 2013, Journal of the Neurological Sciences.

[39]  R. Bergamaschi,et al.  Electrophysiological patterns of oropharyngeal swallowing in multiple sclerosis , 2013, Clinical Neurophysiology.

[40]  D. S. Sales,et al.  Translation, cross-cultural adaptation and validation of the Portuguese version of the DYMUS questionnaire for the assessment of dysphagia in multiple sclerosis , 2013, SpringerPlus.

[41]  C. Tilbery,et al.  Oropharyngeal dysphagia in patients with multiple sclerosis: do the disease classification scales reflect dysphagia severity? , 2013, Brazilian journal of otorhinolaryngology.

[42]  S. Danesh-Sani,et al.  Clinical assessment of orofacial manifestations in 500 patients with multiple sclerosis. , 2013, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[43]  A. Minagar,et al.  Oropharyngeal dysphagia in multiple sclerosis , 2010, Multiple sclerosis.

[44]  A. Ghezzi,et al.  Validation of the DYMUS questionnaire for the assessment of dysphagia in multiple sclerosis. , 2009, Functional neurology.

[45]  R. Bergamaschi,et al.  The DYMUS questionnaire for the assessment of dysphagia in multiple sclerosis , 2008, Journal of the Neurological Sciences.

[46]  0584 Evaluation of the swallowing in 31 patients with multiple sclerosis by speech therapist , 2005, Journal of the Neurological Sciences.

[47]  E. Ross,et al.  Perceptions of the Impact of Speech, Language, Swallowing, and Hearing Difficulties on Quality of Life of a Group of South African Persons with Multiple Sclerosis , 2002, Folia Phoniatrica et Logopaedica.

[48]  W. Steinbrich,et al.  Swallowing abnormalities in multiple sclerosis: correlation between videofluoroscopy and subjective symptoms , 2002, European Radiology.

[49]  S. Paolucci,et al.  Dysphagia in multiple sclerosis – prevalence and prognostic factors , 2002, Acta neurologica Scandinavica.

[50]  C. M. Wiles,et al.  Dysphagia and nutritional status in multiple sclerosis , 1999, Journal of Neurology.

[51]  N. Larocca,et al.  Neurologic Impairment and Disability Status in Outpatients with Multiple Sclerosis Reporting Dysphagia Symptomatology , 1997 .

[52]  D. Daly,et al.  Disturbances of swallowing and esophageal motility in patients with multiple sclerosis , 1962, Neurology.

[53]  D. Smithard.  Dysphagia: A Geriatric Giant? , 2016 .

[54]  R. Terré-Boliart,et al.  [Oropharyngeal dysphagia in patients with multiple sclerosis]. , 2004, Revista de neurologia.

[55]  L. Hartelius,et al.  Speech and swallowing symptoms associated with Parkinson's disease and multiple sclerosis: a survey. , 1994, Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics.