Probing hepatic metabolism of [2-13C]dihydroxyacetone in vivo with 1H-decoupled hyperpolarized 13C-MR

[1]  James A Bankson,et al.  Kinetic Analysis of Hepatic Metabolism Using Hyperpolarized Dihydroxyacetone , 2019, J. Chem. Inf. Model..

[2]  Christoffer Laustsen,et al.  Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology , 2018, Neoplasia.

[3]  S. Lyon,et al.  The Unexpected Role of Carbonate Impurities in Polyphosphate Corrosion Inhibition , 2018, Scientific Reports.

[4]  K. Brindle,et al.  Photogenerated Radical in Phenylglyoxylic Acid for in Vivo Hyperpolarized 13C MR with Photosensitive Metabolic Substrates , 2018, Journal of the American Chemical Society.

[5]  Albert P. Chen,et al.  Sensitivity enhancement for detection of hyperpolarized 13C MRI probes with 1H spin coupling introduced by enzymatic transformation in vivo , 2018, Magnetic resonance in medicine.

[6]  V. de Lédinghen,et al.  Noninvasive biomarkers in NAFLD and NASH — current progress and future promise , 2018, Nature Reviews Gastroenterology & Hepatology.

[7]  Sigrun Goluch,et al.  Proton-decoupled carbon magnetic resonance spectroscopy in human calf muscles at 7 T using a multi-channel radiofrequency coil , 2018, Scientific Reports.

[8]  C J Kelly,et al.  Utility and cost evaluation of multiparametric magnetic resonance imaging for the assessment of non‐alcoholic fatty liver disease , 2018, Alimentary pharmacology & therapeutics.

[9]  J. Kurhanewicz,et al.  Non-invasive detection of divergent metabolic signals in insulin deficiency vs. insulin resistance in vivo , 2018, Scientific Reports.

[10]  John M Pauly,et al.  Spectrally selective three‐dimensional dynamic balanced steady‐state free precession for hyperpolarized C‐13 metabolic imaging with spectrally selective radiofrequency pulses , 2017, Magnetic resonance in medicine.

[11]  P. Larson,et al.  Combining hyperpolarized 13C MRI with a liver‐specific gadolinium contrast agent for selective assessment of hepatocyte metabolism , 2017, Magnetic resonance in medicine.

[12]  M. Robson,et al.  Multiparametric magnetic resonance imaging for the assessment of non‐alcoholic fatty liver disease severity , 2017, Liver international : official journal of the International Association for the Study of the Liver.

[13]  P. Cao,et al.  Multiband spectral‐spatial RF excitation for hyperpolarized [2‐13C]dihydroxyacetone 13C‐MR metabolism studies , 2017, Magnetic resonance in medicine.

[14]  Marram P. Olson,et al.  Detection of localized changes in the metabolism of hyperpolarized gluconeogenic precursors 13C‐lactate and 13C‐pyruvate in kidney and liver , 2017, Magnetic resonance in medicine.

[15]  P. Cao,et al.  Monitoring acute metabolic changes in the liver and kidneys induced by fructose and glucose using hyperpolarized [2‐13C]dihydroxyacetone , 2017, Magnetic resonance in medicine.

[16]  M. Keller,et al.  Hyperpolarized [U‐2H, U‐13C]Glucose reports on glycolytic and pentose phosphate pathway activity in EL4 tumors and glycolytic activity in yeast cells , 2015, Magnetic resonance in medicine.

[17]  K. Brindle,et al.  13C magnetic resonance spectroscopic imaging of hyperpolarized [1‐13C, U‐2H5] ethanol oxidation can be used to assess aldehyde dehydrogenase activity in vivo , 2015, Magnetic resonance in medicine.

[18]  M. Merritt,et al.  Hyperpolarized Magnetic Resonance as a Sensitive Detector of Metabolic Function , 2014, Biochemistry.

[19]  R. Deberardinis,et al.  Real-time Detection of Hepatic Gluconeogenic and Glycogenolytic States Using Hyperpolarized [2-13C]Dihydroxyacetone* , 2014, The Journal of Biological Chemistry.

[20]  TL Jensen,et al.  Fasting of mice: a review , 2013, Laboratory animals.

[21]  Jean S. Campbell,et al.  Liver regeneration. , 2012, Journal of hepatology.

[22]  S. Burgess,et al.  Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease. , 2011, Cell metabolism.

[23]  S. Burgess,et al.  Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized 13C magnetic resonance , 2011, Proceedings of the National Academy of Sciences.

[24]  Peder E. Z. Larson,et al.  Multiband excitation pulses for hyperpolarized 13C dynamic chemical-shift imaging. , 2008, Journal of magnetic resonance.

[25]  R. Gruetter,et al.  Design and performance of a DNP prepolarizer coupled to a rodent MRI scanner , 2007 .

[26]  G. Michalopoulos,et al.  Liver Regeneration , 1997, Journal of cellular physiology.

[27]  Jimmy D Bell,et al.  Evidence for altered hepatic gluconeogenesis in patients with cirrhosis using in vivo 31-phosphorus magnetic resonance spectroscopy , 2001, Gut.

[28]  J. Peret,et al.  Development of gluconeogenesis from dihydroxyacetone in rat hepatocytes during a feeding cycle and starvation. , 1984, The Biochemical journal.

[29]  O. H. Lowry,et al.  Effect of fructose, dihydroxyacetone, glycerol, and glucose on metabolites and related compounds in liver and kidney. , 1970, The Journal of biological chemistry.

[30]  E. Mason,et al.  DIHYDROXYACETONE STUDIES: I. Its Respiratory and Carbohydrate Metabolism in Normal Men. , 1926, The Journal of clinical investigation.