The Bionode

Implantable closed-loop neuromodulation devices for use in long-term chronic studies in a lab or clinical trial are expensive to acquire and difficult to modify for specific use cases. This article documents the design and fabrication of a wireless implantable device using only commercially available off-the-shelf (COTS) components. This device, called the Bionode, can record and transmit up to four channels of biopotential data while simultaneously providing biphasic constant-current stimulation. The Bionode is a viable, low-cost, reusable, and easily modifiable research tool with clinical implications that has gained widespread use in various research projects at Purdue University.

[1]  Marco Weiergräber,et al.  Electrocorticographic and deep intracerebral EEG recording in mice using a telemetry system. , 2005, Brain research. Brain research protocols.

[2]  Felice T. Sun,et al.  Responsive cortical stimulation for the treatment of epilepsy , 2011, Neurotherapeutics.

[3]  Jun Li,et al.  A fully implantable stimulator with wireless power and data transmission for experimental use in epidural spinal cord stimulation , 2011, 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[4]  D. Pozar.  Microwave Engineering , 1990 .

[5]  J. Luigjes,et al.  Deep brain stimulation in addiction: a review of potential brain targets , 2012, Molecular Psychiatry.

[6]  P. Krack,et al.  Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease. , 2001, The New England journal of medicine.

[7]  Karim Abdelhalim,et al.  Closed-Loop Neurostimulators: A Survey and A Seizure-Predicting Design Example for Intractable Epilepsy Treatment , 2017, IEEE Transactions on Biomedical Circuits and Systems.

[8]  Jesse P Somann.  A Study of Techniques and Mechanisms of Vagus Nerve Stimulation for Treatment of Inflammation , 2018 .

[9]  Paul R. Stoddart,et al.  Optical Stimulation of Neurons , 2014, Current molecular imaging.

[10]  Pedro P. Irazoqui,et al.  Optimal Wireless Power Transfer to Systems in an Enclosed Resonant Cavity , 2016, IEEE Antennas and Wireless Propagation Letters.

[11]  Cole A. Giller,et al.  Vagus Nerve Stimulation (VNS™) for Treatment-Resistant Depression: Efficacy, Side Effects, and Predictors of Outcome , 2001, Neuropsychopharmacology.

[12]  Pedro P. Irazoqui,et al.  A Miniature, Fiber-Coupled, Wireless, Deep-Brain Optogenetic Stimulator , 2015, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[13]  Pedro P. Irazoqui,et al.  Miniaturizing wireless implants , 2014, Nature Biotechnology.

[14]  G. Ahern,et al.  Vagus nerve stimulation therapy in depression and epilepsy: therapeutic parameter settings , 2007, Acta neurologica Scandinavica.

[15]  Karim Abdelhalim,et al.  Battery-less Tri-band-Radio Neuro-monitor and Responsive Neurostimulator for Diagnostics and Treatment of Neurological Disorders , 2016, IEEE Journal of Solid-State Circuits.

[16]  Ken Stokes,et al.  The Biocompatibility and Biostability of New Cardiovascular Materials and Devices , 2009 .

[17]  Emad N. Eskandar,et al.  Package architecture and component design for an implanted neural stimulator with closed loop control , 2015, 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[18]  J. Mellanby,et al.  Long‐term changes in hippocampal physiology and learning ability of rats after intrahippocampal tetanus toxin. , 1985, The Journal of physiology.

[19]  Frederick F. Driscoll,et al.  Operational Amplifiers and Linear Integrated Circuits , 1977 .

[20]  Guangqiang Jiang,et al.  Technology Advances and Challenges in Hermetic Packaging for Implantable Medical Devices , 2009 .

[21]  Aime Lay-Ekuakille,et al.  Experimental characterization of an implantable neuro-packaging for EEG signal recording and measurement , 2016 .

[22]  Timos Papadopoulos,et al.  Emerging technologies for biological recording , 2015 .

[23]  W. H. Ko,et al.  Long-term evaluation of a non-hermetic micropackage technology for MEMS-based, implantable pressure sensors , 2015, 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS).

[24]  Paul P Breen,et al.  BION microstimulators: a case study in the engineering of an electronic implantable medical device. , 2011, Medical engineering & physics.

[25]  Nitish V. Thakor,et al.  Implantable neurotechnologies: electrical stimulation and applications , 2015, Medical & Biological Engineering & Computing.

[26]  Jennifer Urner,et al.  Antenna Theory And Design , 2016 .

[27]  Carlos Segura,et al.  An implantable, designed-for-human-use peripheral nerve stimulation and recording system for advanced prosthetics , 2016, 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[28]  Thomas Stieglitz,et al.  Non-hermetic encapsulation for implantable electronic devices based on epoxy , 2015, 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[29]  Takehiro Imura,et al.  Automated Impedance Matching System for Robust Wireless Power Transfer via Magnetic Resonance Coupling , 2013, IEEE Transactions on Industrial Electronics.

[30]  J. Faulkner,et al.  An implantable device for stimulation of denervated muscles in rats. , 2003, Medical engineering & physics.

[31]  Anthony A. Grace,et al.  An inexpensive, charge-balanced rodent deep brain stimulation device: A step-by-step guide to its procurement and construction , 2013, Journal of Neuroscience Methods.

[32]  R. A. Stevenson.  Feedthrough EMI filter with ground isolation for cardiac pacemakers and implantable cardioverter defibrillators , 1998, Proceedings of the 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Vol.20 Biomedical Engineering Towards the Year 2000 and Beyond (Cat. No.98CH36286).

[33]  William J. Chappell,et al.  Power distribution to multiple implanted sensor devices using a multiport bandpass filter (BPF) approach , 2014, 2014 IEEE MTT-S International Microwave Symposium (IMS2014).

[34]  Peter A. Tass,et al.  Capacitive Feedthroughs for Medical Implants , 2016, Front. Neurosci..

[35]  John G. R. Jefferys,et al.  Cavity Resonator Wireless Power Transfer System for Freely Moving Animal Experiments , 2017, IEEE Transactions on Biomedical Engineering.

[36]  Frederick F. Driscoll,et al.  Operational amplifiers and linear integrated circuits, 3rd ed. , 1987 .

[37]  Anne Vanhoestenberghe,et al.  Silicone rubber encapsulation for an endoscopically implantable gastrostimulator , 2015, Medical & Biological Engineering & Computing.

[38]  Constantine A. Balanis,et al.  Antenna Theory: Analysis and Design , 1982 .

[39]  Daniel R. Merrill,et al.  Electrical stimulation of excitable tissue: design of efficacious and safe protocols , 2005, Journal of Neuroscience Methods.

[40]  Qi Xu,et al.  A Fully Implantable Stimulator With Wireless Power and Data Transmission for Experimental Investigation of Epidural Spinal Cord Stimulation , 2015, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[41]  Haiqiao Xiao,et al.  Design of Analog Filters 2nd Edition , 2009 .

[42]  Hung Cao,et al.  Power Approaches for Implantable Medical Devices , 2015, Sensors.