Inducible short-term and stable long-term cell culture systems reveal that the PAX3-FKHR fusion oncoprotein regulates CXCR4, PAX3, and PAX7 expression

[1]  R. Williams,et al.  PAX7 expression in embryonal rhabdomyosarcoma suggests an origin in muscle satellite cells , 2003, British Journal of Cancer.

[2]  Oana A. Tomescu,et al.  CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion. , 2002, Blood.

[3]  P. Sorensen,et al.  PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[4]  F. Barr Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma , 2001, Oncogene.

[5]  K. Pritchard-Jones,et al.  PAX3-FKHR induces morphological change and enhances cellular proliferation and invasion in rhabdomyosarcoma. , 2001, The American journal of pathology.

[6]  M. Moore,et al.  The role of chemoattraction in cancer metastases. , 2001, BioEssays : news and reviews in molecular, cellular and developmental biology.

[7]  T. Mcclanahan,et al.  Involvement of chemokine receptors in breast cancer metastasis , 2001, Nature.

[8]  Chulhee Choi,et al.  CXC Chemokine Receptor 4 Expression and Function in Human Astroglioma Cells1 , 2001, The Journal of Immunology.

[9]  A. Hidalgo,et al.  Chemokine stromal cell-derived factor-1alpha modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1/fibronectin and VCAM-1. , 2001, Blood.

[10]  C. Berking,et al.  Hormone-dependent tumor regression in vivo by an inducible transcriptional repressor directed at the PAX3-FKHR oncogene. , 2000, Cancer research.

[11]  M. Imamura,et al.  Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: a possible role for tumor progression. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

[12]  L. Peso,et al.  Regulation of the forkhead transcription factor FKHR, but not the PAX3-FKHR fusion protein, by the serine/threonine kinase Akt , 1999, Oncogene.

[13]  T. Kipps,et al.  Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells. , 1999, Blood.

[14]  R. Davis,et al.  Predominant expression of alternative PAX3 and PAX7 forms in myogenic and neural tumor cell lines. , 1999, Cancer research.

[15]  Michael L. Bittner,et al.  cDNA microarrays detect activation of a myogenic transcription program by the PAX3-FKHR fusion oncogene , 1999, Nature Genetics.

[16]  B. Schäfer,et al.  PAX3 and PAX7 exhibit conserved cis-acting transcription repression domains and utilize a common gain of function mechanism in alveolar rhabdomyosarcoma , 1999, Oncogene.

[17]  J. Epstein,et al.  Pax3 functions in cell survival and in pax7 regulation. , 1999, Development.

[18]  M. Roussel,et al.  The Oncogenic Potential of the Pax3-FKHR Fusion Protein Requires the Pax3 Homeodomain Recognition Helix but Not the Pax3 Paired-Box DNA Binding Domain , 1999, Molecular and Cellular Biology.

[19]  X Zhang,et al.  A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140. , 1998, Biochemical and biophysical research communications.

[20]  R. Davis,et al.  Up-regulation of MET but not neural cell adhesion molecule expression by the PAX3-FKHR fusion protein in alveolar rhabdomyosarcoma. , 1998, Cancer research.

[21]  R. Davis,et al.  Fusion genes resulting from alternative chromosomal translocations are overexpressed by gene-specific mechanisms in alveolar rhabdomyosarcoma. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[22]  B. Schäfer,et al.  Induction of apoptosis in rhabdomyosarcoma cells through down-regulation of PAX proteins. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[23]  P. Vogt,et al.  The hybrid PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma transforms fibroblasts in culture. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[24]  F. Barr,et al.  Mechanism for transcriptional gain of function resulting from chromosomal translocation in alveolar rhabdomyosarcoma. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[25]  F. Barr,et al.  Wild type PAX3 protein and the PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma contain potent, structurally distinct transcriptional activation domains. , 1995, Oncogene.

[26]  G. Evan,et al.  A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. , 1995, Nucleic acids research.

[27]  J. Epstein,et al.  Pax3 Inhibits Myogenic Differentiation of Cultured Myoblast Cells (*) , 1995, The Journal of Biological Chemistry.

[28]  J. Biegel,et al.  Molecular assays for chromosomal translocations in the diagnosis of pediatric soft tissue sarcomas. , 1995, JAMA.

[29]  J. Biegel,et al.  Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma. , 1994, Cancer research.

[30]  B. Emanuel,et al.  Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma , 1993, Nature Genetics.

[31]  H. Weintraub,et al.  Use of a conditional MyoD transcription factor in studies of MyoD trans-activation and muscle determination. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[32]  A. Craft,et al.  Alveolar rhabdomyosarcoma infiltrating bone marrow at presentation: the value to diagnosis of bone marrow trephine biopsy specimens. , 1992, Journal of clinical pathology.

[33]  T. Kinsella,et al.  Rhabdomyosarcoma. A new classification scheme related to prognosis. , 1992, Archives of pathology & laboratory medicine.

[34]  M. Bucan,et al.  Sequential expression of murine homeo box genes during F9 EC cell differentiation. , 1986, The EMBO journal.

[35]  K. Pienta,et al.  Prostate Cancer Metastasis to Bone Use of the Stromal Cell-derived Factor-1 / CXCR 4 Pathway in Updated Version , 2002 .