Glaucomas: Glaucoma and the Cornea

From the glaucoma specialist’s standpoint, the cornea has generated a great deal of interest since the Ocular Hypertension Treatment Study (OHTS) highlighted the importance of central corneal thickness as a risk factor for glaucoma development. The cornea has always been important though, because a compact and transparent cornea is necessary for a clear view of the optic nerve, for good visual acuity to perform visual fields, and for accurate measurements of intraocular pressure. The effects of glaucoma and glaucoma treatment on the corneal endothelium are of particular concern, as a compromised endothelium poses a great risk for corneal decompensation.

[1]  H. Heinzl,et al.  Effect of dorzolamide hydrochloride on central corneal thickness in humans with cornea guttata. , 2007, Archives of ophthalmology.

[2]  A. Balestrazzi,et al.  An in vivo confocal microscopy analysis of effects of topical antiglaucoma therapy with preservative on corneal innervation and morphology. , 2009, American journal of ophthalmology.

[3]  M. Lesk,et al.  Dorzolamide and corneal recovery from edema in patients with glaucoma or ocular hypertension. , 2000, American journal of ophthalmology.

[4]  R. Hitchings,et al.  Reversal of topical antiglaucoma medication effects on the conjunctiva. , 1996, Archives of ophthalmology.

[5]  R. Sihota,et al.  Corneal endothelial status in the subtypes of primary angle closure glaucoma , 2003, Clinical & experimental ophthalmology.

[6]  S. Kaminski,et al.  Influence of dorzolamide on corneal thickness, endothelial cell count and corneal sensibility. , 1998, Acta ophthalmologica Scandinavica.

[7]  D. Tingey,et al.  Corneal endothelial response to polymethylmethacrylate versus hydrogel lenses after phacoemulsification. , 1991, Canadian journal of ophthalmology. Journal canadien d'ophtalmologie.

[8]  M. Araie,et al.  Concentration change of fluorouracil in the external segment of the eye after subconjunctival injection. , 1988, Archives of ophthalmology.

[9]  P. Weber,et al.  Corneal decompensation after argon laser iridectomy. , 1988, Archives of ophthalmology.

[10]  C. O'brien,et al.  Adverse effects of topical antiglaucoma medication. II. The outcome of filtration surgery. , 1994 .

[11]  S. Gedde,et al.  Long-term surgical outcomes of patients with glaucoma secondary to the iridocorneal endothelial syndrome. , 2001, Ophthalmology.

[12]  Paul P. Lee,et al.  Mitomycin-C concentration in human aqueous humour following trabeculectomy , 1993, Eye.

[13]  I. Schwab,et al.  The long-term results of keratoplasty in eyes with a glaucoma drainage device. , 2004, American journal of ophthalmology.

[14]  Falcon Mg,et al.  Herpes simplex kerato-uveitis and glaucoma. , 1978 .

[15]  D. Shin,et al.  Assessment of corneal decompensation in eyes having undergone molteno shunt procedures compared to eyes having undergone trabeculectomy. , 1999, The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc.

[16]  J. Lee,et al.  Corneal decompensation after argon laser iridectomy--a delayed complication. , 1991, Ophthalmic surgery.

[17]  T. Żarnowski,et al.  [Corneal endothelial density in glaucoma patients]. , 2005, Klinika oczna.

[18]  M. Juzych,et al.  Corneal endothelial cell counts after Molteno implantation. , 1993, American journal of ophthalmology.

[19]  K. Green,et al.  Corneal endothelium bicarbonate transport and the effect of carbonic anhydrase inhibitors on endothelial permeability and fluxes and corneal thickness. , 1977, Investigative ophthalmology & visual science.

[20]  W. Petroll,et al.  Assessment of corneal epithelial integrity after acute exposure to ocular hypotensive agents preserved with and without benzalkonium chloride , 2006, Advances in therapy.

[21]  J. V. van Best,et al.  Corneal epithelial permeability after instillation of ophthalmic solutions containing local anaesthetics and preservatives. , 1988, Current eye research.

[22]  I. Adamsons,et al.  A double-masked, randomized, 1-year study comparing the corneal effects of dorzolamide, timolol, and betaxolol. Dorzolamide Corneal Effects Study Group. , 1998, Archives of ophthalmology.

[23]  G. Skuta,et al.  The effect of glaucoma filtering surgery on corneal endothelial cell density. , 1991, Ophthalmic surgery.

[24]  R. Allen,et al.  Do injections of 5-fluorouracil after trabeculectomy have toxic effects on the anterior segment? , 2005, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

[25]  V. Shanmuganathan,et al.  Argon laser iridotomy-induced bullous keratopathy—a growing problem in Japan , 2007, British Journal of Ophthalmology.

[26]  Xianyin Lai,et al.  Alterations in the aqueous humor proteome in patients with a glaucoma shunt device , 2011, Molecular vision.

[27]  N. Efron,et al.  Subbasal Nerve Regeneration After Penetrating Keratoplasty , 2007, Cornea.

[28]  L. Clearkin.  Adverse effects of topical antiglaucoma medication. , 1995, Archives of ophthalmology.

[29]  R. Witmer,et al.  Corneal endothelial changes in primary acute angle-closure glaucoma. , 1982, Ophthalmology.

[30]  I. MacDonald,et al.  Corneal endothelial decompensation after argon laser iridotomy. , 1991, Canadian journal of ophthalmology. Journal canadien d'ophtalmologie.

[31]  J. McLaren,et al.  Effects of Glaucoma Medications on Corneal Endothelium, Keratocytes, and Subbasal Nerves Among Participants in the Ocular Hypertension Treatment Study , 2006, Cornea.

[32]  M. Sherwood,et al.  Corneal thickness and endothelial cell density measured by non-contact specular microscopy and pachymetry in Rhesus macaques (Macaca mulatta) with laser-induced ocular hypertension. , 2003, Experimental eye research.

[33]  Y. Ohashi,et al.  Demonstration of aqueous streaming through a laser iridotomy window against the corneal endothelium. , 2006, Archives of ophthalmology.

[34]  R. Yee,et al.  Comparison of the relative toxicity of travoprost 0.004% without benzalkonium chloride and latanoprost 0.005% in an immortalized human cornea epithelial cell culture system , 2006, Advances in therapy.

[35]  C. Baudouin,et al.  Prevalence of ocular symptoms and signs with preserved and preservative free glaucoma medication , 2002, The British journal of ophthalmology.

[36]  M. Whitacre,et al.  Sources of error with use of Goldmann-type tonometers. , 1993, Survey of ophthalmology.

[37]  J. McLaren,et al.  Clinical responses of the corneal endothelium. , 2004, Experimental eye research.

[38]  H. Abe,et al.  Corneal Endothelial Damage After Trabeculectomy With Mitomycin C in Two Patients With Glaucoma With Cornea Guttata , 2002, Cornea.

[39]  T. Werblin.  Long-term endothelial cell loss following phacoemulsification: model for evaluating endothelial damage after intraocular surgery. , 1993, Refractive & corneal surgery.

[40]  K. Wilhelmus.  Corneal edema following argon laser iridotomy. , 1992, Ophthalmic surgery.

[41]  H. Rouhiainen,et al.  Corneal endothelial cell density after trabeculoplasty. , 1988, Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde.

[42]  C. O'brien,et al.  Adverse effects of topical antiglaucoma medication. I. The conjunctival cell profile. , 1994 .

[43]  Kenji Inoue,et al.  Influence of dorzolamide on corneal endothelium. , 2003, Japanese journal of ophthalmology.

[44]  Karim F. Damji,et al.  Influence of Corneal Variables on Accuracy of Intraocular Pressure Measurement , 2003, Journal of glaucoma.

[45]  Minho Yang,et al.  Mitomycin-C Concentration in Cornea and Aqueous Humor and Apoptosis in the Stroma After Topical Mitomycin-C Application: Effects of Mitomycin-C Application Time and Concentration , 2007, Cornea.

[46]  B. Shingleton,et al.  The effect of anterior chamber depth on endothelial cell count after filtration surgery. , 1989, Archives of ophthalmology.

[47]  T. Zeyen,et al.  Ocular Symptoms and Signs with Preserved and Preservative-Free Glaucoma Medications , 2007, European journal of ophthalmology.

[48]  S. Natarajan,et al.  Aspergillus-induced Malignant Glaucoma , 2007, Cornea.

[49]  R O Schultz,et al.  Changes in the normal corneal endothelial cellular pattern as a function of age. , 1985, Current eye research.

[50]  T. Aung,et al.  Inferior corneal decompensation following laser peripheral iridotomy in the superior iris. , 2006, American journal of ophthalmology.

[51]  L. Pasquale,et al.  Herpes Simplex Virus: An Important Etiology for Secondary Glaucoma , 2007, International ophthalmology clinics.

[52]  I. Brunette,et al.  Corneal Endothelial Cell Density in Glaucoma , 1997, Cornea.

[53]  Show-Jen Hong,et al.  Toxic effects of mitomycin-C on cultured corneal keratocytes and endothelial cells. , 1999, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

[54]  J. Morrison,et al.  Irreversible corneal decompensation in patients treated with topical dorzolamide. , 1999, American journal of ophthalmology.

[55]  K. Setälä.  CORNEAL ENDOTHELIAL CELL DENSITY AFTER AN ATTACK OF ACUTE GLAUCOMA , 1979, Acta ophthalmologica.

[56]  E. Sherrard,et al.  Damage to the corneal endothelium during Nd/YAG photodisruption. , 1985, The British journal of ophthalmology.