Eosinophils are key regulators of perivascular adipose tissue and vascular functionality

[1]  V. Apostolopoulos,et al.  The complex immunological and inflammatory network of adipose tissue in obesity. , 2016, Molecular nutrition & food research.

[2]  Jonathan R. Brestoff,et al.  Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity , 2014, Nature.

[3]  James J. Lee,et al.  Changing roles of eosinophils in health and disease. , 2014, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[4]  R. Palmiter,et al.  Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat , 2014, Cell.

[5]  Matthias E. Werner,et al.  cGMP-dependent protein kinase (PKG) mediates the anticontractile capacity of perivascular adipose tissue. , 2014, Cardiovascular research.

[6]  Kassem M. Makki,et al.  Adipose Tissue in Obesity-Related Inflammation and Insulin Resistance: Cells, Cytokines, and Chemokines , 2013, ISRN inflammation.

[7]  A. Heagerty,et al.  Stimulated release of a hyperpolarizing factor (ADHF) from mesenteric artery perivascular adipose tissue: involvement of myocyte BKCa channels and adiponectin , 2013, British journal of pharmacology.

[8]  M. Levings,et al.  Immune Regulation in Obesity-Associated Adipose Inflammation , 2013, The Journal of Immunology.

[9]  Matthias E. Werner,et al.  Perivascular adipose tissue-derived adiponectin activates BK(Ca) channels to induce anticontractile responses. , 2013, American journal of physiology. Heart and circulatory physiology.

[10]  S. Hama,et al.  Effects of bariatric surgery on human small artery function: evidence for reduction in perivascular adipocyte inflammation, and restoration of normal anticontractile activity despite persistent obesity , 2013, The Lancet.

[11]  A. Xu,et al.  Interplay between adipose tissue and blood vessels in obesity and vascular dysfunction , 2013, Reviews in Endocrine and Metabolic Disorders.

[12]  D. Mooney,et al.  Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks , 2012, Nature Immunology.

[13]  F. Finkelman,et al.  Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation , 2011, Science.

[14]  R. Locksley,et al.  Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis , 2011, Science.

[15]  S. Daubner,et al.  Tyrosine hydroxylase and regulation of dopamine synthesis. , 2011, Archives of biochemistry and biophysics.

[16]  A. Heagerty,et al.  Macrophage Activation Is Responsible for Loss of Anticontractile Function in Inflamed Perivascular Fat , 2011, Arteriosclerosis, thrombosis, and vascular biology.

[17]  S. Gordon,et al.  Alternative activation of macrophages: mechanism and functions. , 2010, Immunity.

[18]  D. Attwell,et al.  Pericyte-Mediated Regulation of Capillary Diameter: A Component of Neurovascular Coupling in Health and Disease , 2010, Front. Neuroenerg..

[19]  E. Schiffrin,et al.  Endothelial Nitric Oxide Synthase Uncoupling and Perivascular Adipose Oxidative Stress and Inflammation Contribute to Vascular Dysfunction in a Rodent Model of Metabolic Syndrome , 2009, Hypertension.

[20]  M. Ballmaier,et al.  Common γ-Chain-Dependent Signals Confer Selective Survival of Eosinophils in the Murine Small Intestine1 , 2009, The Journal of Immunology.

[21]  A. Heagerty,et al.  Local Inflammation and Hypoxia Abolish the Protective Anticontractile Properties of Perivascular Fat in Obese Patients , 2009, Circulation.

[22]  S. Siegel,et al.  Functionally Competent Eosinophils Differentiated Ex Vivo in High Purity from Normal Mouse Bone Marrow1 , 2008, The Journal of Immunology.

[23]  P. Scherer,et al.  Adiponectin, Cardiovascular Function, and Hypertension , 2008, Hypertension.

[24]  Yu-Jing Gao,et al.  Dual modulation of vascular function by perivascular adipose tissue and its potential correlation with adiposity/lipoatrophy-related vascular dysfunction. , 2007, Current pharmaceutical design.

[25]  S. Kihara,et al.  Adiponectin Replenishment Ameliorates Obesity-Related Hypertension , 2006, Hypertension.

[26]  C. Stehouwer,et al.  “Vasocrine” signalling from perivascular fat: a mechanism linking insulin resistance to vascular disease , 2005, The Lancet.

[27]  M. Gollasch,et al.  Paracrine role for periadventitial adipose tissue in the regulation of arterial tone. , 2004, Trends in pharmacological sciences.

[28]  M. Gollasch,et al.  Visceral Periadventitial Adipose Tissue Regulates Arterial Tone of Mesenteric Arteries , 2004, Hypertension.

[29]  Malcolm W Johnson.  Effects of beta2-agonists on resident and infiltrating inflammatory cells. , 2002, The Journal of allergy and clinical immunology.

[30]  S. Orkin,et al.  Targeted Deletion of a High-Affinity GATA-binding Site in the GATA-1 Promoter Leads to Selective Loss of the Eosinophil Lineage In Vivo , 2002, The Journal of experimental medicine.

[31]  E. Nisoli,et al.  Functional studies of the first selective beta 3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes. , 1996, Molecular pharmacology.

[32]  J. Parker,et al.  Oxygen radical scavengers protect against eosinophil-induced injury in isolated perfused rat lungs. , 1992, Journal of applied physiology.

[33]  M. Mulvany,et al.  Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. , 1977, Circulation research.

[34]  A. Heagerty,et al.  Evidence for Reduction in Perivascular Adipocyte In fl ammation , and the Restoration of Normal Anticontractile Activity Despite Persistent Obesity , 2022 .