Advanced Robotic Therapy Integrated Centers (ARTIC): an international collaboration facilitating the application of rehabilitation technologies

BackgroundThe application of rehabilitation robots has grown during the last decade. While meta-analyses have shown beneficial effects of robotic interventions for some patient groups, the evidence is less in others. We established the Advanced Robotic Therapy Integrated Centers (ARTIC) network with the goal of advancing the science and clinical practice of rehabilitation robotics. The investigators hope to exploit variations in practice to learn about current clinical application and outcomes. The aim of this paper is to introduce the ARTIC network to the clinical and research community, present the initial data set and its characteristics and compare the outcome data collected so far with data from prior studies.MethodsARTIC is a pragmatic observational study of clinical care. The database includes patients with various neurological and gait deficits who used the driven gait orthosis Lokomat® as part of their treatment. Patient characteristics, diagnosis-specific information, and indicators of impairment severity are collected. Core clinical assessments include the 10-Meter Walk Test and the Goal Attainment Scaling. Data from each Lokomat® training session are automatically collected.ResultsAt time of analysis, the database contained data collected from 595 patients (cerebral palsy: n = 208; stroke: n = 129; spinal cord injury: n = 93; traumatic brain injury: n = 39; and various other diagnoses: n = 126). At onset, average walking speeds were slow. The training intensity increased from the first to the final therapy session and most patients achieved their goals.ConclusionsThe characteristics of the patients matched epidemiological data for the target populations. When patient characteristics differed from epidemiological data, this was mainly due to the selection criteria used to assess eligibility for Lokomat® training. While patients included in randomized controlled interventional trials have to fulfill many inclusion and exclusion criteria, the only selection criteria applying to patients in the ARTIC database are those required for use of the Lokomat®. We suggest that the ARTIC network offers an opportunity to investigate the clinical application and effectiveness of rehabilitation technologies for various diagnoses. Due to the standardization of assessments and the use of a common technology, this network could serve as a basis for researchers interested in specific interventional studies expanding beyond the Lokomat®.

Paolo Bonato | Giacomo Severini | Andreas Meyer-Heim | Stella Lee | Liliana P. Paredes | Won-Seok Kim | Gery Colombo | Seng Kwee Wee | Catherine Adans-Dester | Anne O’Brien | Alberto Esquenazi | Lars Lünenburger | Alessandra Scarton | S. K. Wee | Eric Fabara | Nam-Jong Paik | P. H. Lim | Hubertus J. A. van Hedel | Tamsin Reed | Deborah Gaebler-Spira | Tara Egan | Judith Graser | Karen Chua | Daniel Zutter | Raoul Schweinfurther | J. Carsten Möller | Steffen Berweck | Sebastian Schroeder | Birgit Warken | Anne Chan | Amber Devers | Jakub Petioky | Michael Boninger | Eric Catherine Jean Lori Gadi Stella Theresa Kay Fei Se Fabara Adans-Dester O’Brien Murby Laliberte | Jean O’Brien Murby | Lori Laliberte | Gadi Revivo | Theresa Toczylowski | Kay Fei Chan | Pang Hung Lim | Wei Sheong Lim | Juliana Yun Ying Wang | Wing Kuen Lee | Chui Ni Ong | Cheng Hong Ong | Charlene Cheryl Pereira | Siew Yee Lee | Alexander Dewor | Michael Urban | Tabea Aurich | Anja Lucic | Thomas Nastulla | Katharina Badura | Josephine Steinbichler | Myungki Ji | Yunsung Oh | Salvatore Calabro | Leslie van Hiel | Martina Spiess | Irin Maier | M. Boninger | A. Esquenazi | G. Colombo | P. Bonato | H. V. van Hedel | A. Meyer-Heim | A. Lucic | D. Zutter | G. Severini | L. Lünenburger | A. Scarton | A. O'Brien | T. Reed | D. Gaebler-Spira | T. Egan | J. Graser | K. Chua | R. Schweinfurther | J. C. Möller | L. Paredes | S. Berweck | S. Schroeder | B. Warken | A. Chan | A. Devers | J. Pětioký | N. Paik | Wonseok Kim | E. C. J. L. G. S. T. K. F. S. Fabara Adans-Dester O’Brien Murby Laliberte Revivo | E. Fabara | C. Adans-Dester | J. O’Brien Murby | L. Laliberte | G. Revivo | Stella Lee | T. Toczylowski | K. Chan | W. S. Lim | J. Y. Y. Wang | W. K. Lee | C. N. Ong | C. H. Ong | C. C. Pereira | Siew Yee Lee | A. Dewor | M. Urban | T. Aurich | T. Nastulla | K. Badura | J. Steinbichler | M. Ji | Y. Oh | S. Calabro | L. van Hiel | M. Spiess | I. Maier

[1]  D. Wade,et al.  Walking after stroke. Measurement and recovery over the first 3 months. , 2020, Scandinavian journal of rehabilitation medicine.

[2]  C. Granger,et al.  The functional independence measure: a new tool for rehabilitation. , 1987, Advances in clinical rehabilitation.

[3]  Richard W. Bohannon,et al.  Interrater reliability of a modified Ashworth scale of muscle spasticity. , 1987, Physical therapy.

[4]  M. Msall,et al.  The Functional Independence Measure for Children (WeeFIM) , 1994, Clinical pediatrics.

[5]  R. Palisano,et al.  Development and reliability of a system to classify gross motor function in children with cerebral palsy , 1997, Developmental medicine and child neurology.

[6]  K.,et al.  Reliability of measurements of muscle tone and muscle power in stroke patients. , 2000, Age and ageing.

[7]  V. Dietz,et al.  Driven gait orthosis for improvement of locomotor training in paraplegic patients , 2001, Spinal Cord.

[8]  C. Richards,et al.  Responsiveness and predictability of gait speed and other disability measures in acute stroke. , 2001, Archives of physical medicine and rehabilitation.

[9]  D. Wade,et al.  Validity and reliability comparison of 4 mobility measures in patients presenting with neurologic impairment. , 2001, Archives of physical medicine and rehabilitation.

[10]  V. Dietz,et al.  Providing the clinical basis for new interventional therapies: refined diagnosis and assessment of recovery after spinal cord injury , 2004, Spinal Cord.

[11]  B. Dan,et al.  Proposed definition and classification of cerebral palsy, April 2005. , 2005, Developmental medicine and child neurology.

[12]  G. Lankhorst,et al.  The effect of botulinum toxin type A treatment of the lower extremity on the level of functional abilities in children with cerebral palsy: evaluation with goal attainment scaling , 2005, Clinical rehabilitation.

[13]  Thomas J. Kiresuk,et al.  Goal attainment scaling: A general method for evaluating comprehensive community mental health programs , 1968, Community Mental Health Journal.

[14]  Volker Dietz,et al.  Assessing walking ability in subjects with spinal cord injury: validity and reliability of 3 walking tests. , 2005, Archives of physical medicine and rehabilitation.

[15]  M. Wirz,et al.  Improving walking assessment in subjects with an incomplete spinal cord injury: responsiveness , 2006, Spinal Cord.

[16]  I. Kneebone,et al.  Goal setting as an outcome measure: a systematic review , 2006, Clinical rehabilitation.

[17]  D. Steenbeek,et al.  Goal attainment scaling in paediatric rehabilitation: a critical review of the literature , 2007, Developmental medicine and child neurology.

[18]  A. Mayr,et al.  Prospective, Blinded, Randomized Crossover Study of Gait Rehabilitation in Stroke Patients Using the Lokomat Gait Orthosis , 2007, Neurorehabilitation and neural repair.

[19]  F. Müller,et al.  Effects of Locomotion Training With Assistance of a Robot-Driven Gait Orthosis in Hemiparetic Patients After Stroke: A Randomized Controlled Pilot Study , 2007, Stroke.

[20]  Kelly P Westlake,et al.  Pilot study of Lokomat versus manual-assisted treadmill training for locomotor recovery post-stroke , 2009, Journal of NeuroEngineering and Rehabilitation.

[21]  Marcel Dijkers,et al.  The SCIRehab Project: classification and quantification of spinal cord injury rehabilitation treatments. Preface. , 2009, The journal of spinal cord medicine.

[22]  C. V. van Heugten,et al.  The practical use of goal attainment scaling for people with acquired brain injury who receive cognitive rehabilitation , 2009, Clinical rehabilitation.

[23]  I. Schwartz,et al.  The Effectiveness of Locomotor Therapy Using Robotic‐Assisted Gait Training in Subacute Stroke Patients: A Randomized Controlled Trial , 2009, PM & R : the journal of injury, function, and rehabilitation.

[24]  H. V. Hedel,et al.  Gait Speed in Relation to Categories of Functional Ambulation After Spinal Cord Injury , 2009 .

[25]  J. Hidler,et al.  Multicenter Randomized Clinical Trial Evaluating the Effectiveness of the Lokomat in Subacute Stroke , 2009, Neurorehabilitation and neural repair.

[26]  D. Steenbeek,et al.  Interrater reliability of goal attainment scaling in rehabilitation of children with cerebral palsy. , 2010, Archives of physical medicine and rehabilitation.

[27]  M. Wald,et al.  Traumatic brain injury in the United States; emergency department visits, hospitalizations, and deaths, 2002-2006 , 2010 .

[28]  I. Krägeloh-Mann,et al.  Trends in prevalence of cerebral palsy in children born with a birthweight of 2,500 g or over in Europe from 1980 to 1998 , 2010, European Journal of Epidemiology.

[29]  R. Meeusen,et al.  Effectiveness of robot-assisted gait training in persons with spinal cord injury: a systematic review. , 2010, Journal of rehabilitation medicine.

[30]  Robert Riener,et al.  Virtual reality for enhancement of robot-assisted gait training in children with central gait disorders. , 2011, Journal of rehabilitation medicine.

[31]  V. Dietz,et al.  Effectiveness of automated locomotor training in patients with acute incomplete spinal cord injury: A randomized controlled multicenter trial , 2011, BMC neurology.

[32]  K. Roach,et al.  Influence of a Locomotor Training Approach on Walking Speed and Distance in People With Chronic Spinal Cord Injury: A Randomized Clinical Trial , 2011, Physical Therapy.

[33]  Andrei Krassioukov,et al.  International standards for neurological classification of spinal cord injury, revised 2011. , 2012, Topics in spinal cord injury rehabilitation.

[34]  R. Müller,et al.  Leg surface electromyography patterns in children with neuro-orthopedic disorders walking on a treadmill unassisted and assisted by a robot with and without encouragement , 2012, Journal of NeuroEngineering and Rehabilitation.

[35]  M. J. Hall,et al.  Hospitalization for stroke in U.S. hospitals, 1989-2009. , 2012, NCHS data brief.

[36]  R. Meeusen,et al.  Treadmill Training in Multiple Sclerosis: Can Body Weight Support or Robot Assistance Provide Added Value? A Systematic Review , 2012, Multiple sclerosis international.

[37]  J. Mehrholz,et al.  Locomotor training for walking after spinal cord injury. , 2012, The Cochrane database of systematic reviews.

[38]  Mónica Alcobendas-Maestro,et al.  Lokomat Robotic-Assisted Versus Overground Training Within 3 to 6 Months of Incomplete Spinal Cord Lesion , 2012, Neurorehabilitation and neural repair.

[39]  Joanna Dudek,et al.  Functional effects of robotic-assisted locomotor treadmill thearapy in children with cerebral palsy. , 2013, Journal of rehabilitation medicine.

[40]  Corwin Boake,et al.  Over-ground and robotic-assisted locomotor training in adults with chronic stroke: a blinded randomized clinical trial , 2013, Disability and rehabilitation. Assistive technology.

[41]  Alberto Esquenazi,et al.  A Randomized Comparative Study of Manually Assisted Versus Robotic‐Assisted Body Weight Supported Treadmill Training in Persons With a Traumatic Brain Injury , 2013, PM & R : the journal of injury, function, and rehabilitation.

[42]  Paul J Nietert,et al.  The Prevalence of Chronic Diseases and Multimorbidity in Primary Care Practice: A PPRNet Report , 2013, The Journal of the American Board of Family Medicine.

[43]  Rob Labruyère,et al.  Strength training versus robot-assisted gait training after incomplete spinal cord injury: a randomized pilot study in patients depending on walking assistance , 2014, Journal of NeuroEngineering and Rehabilitation.

[44]  Andreas Meyer-Heim,et al.  Requirements for and impact of a serious game for neuro-pediatric robot-assisted gait training. , 2013, Research in developmental disabilities.

[45]  Ana Esclarín-Ruz,et al.  A comparison of robotic walking therapy and conventional walking therapy in individuals with upper versus lower motor neuron lesions: a randomized controlled trial. , 2014, Archives of physical medicine and rehabilitation.

[46]  J. Wyatt,et al.  Better reporting of interventions: template for intervention description and replication (TIDieR) checklist and guide , 2014, BMJ : British Medical Journal.

[47]  Russell S Kirby,et al.  Prevalence of cerebral palsy, co‐occurring autism spectrum disorders, and motor functioning – Autism and Developmental Disabilities Monitoring Network, USA, 2008 , 2014, Developmental medicine and child neurology.

[48]  Romain Meeusen,et al.  Does Robot-Assisted Gait Rehabilitation Improve Balance in Stroke Patients? A Systematic Review , 2014, Topics in stroke rehabilitation.

[49]  T. Lam,et al.  Training with robot-applied resistance in people with motor-incomplete spinal cord injury: Pilot study. , 2015, Journal of rehabilitation research and development.

[50]  Atte Meretoja,et al.  Update on the Global Burden of Ischemic and Hemorrhagic Stroke in 1990-2013: The GBD 2013 Study , 2015, Neuroepidemiology.

[51]  R. D. de Bie,et al.  Difficulties of Using Single-Diseased Guidelines to Treat Patients with Multiple Diseases , 2015, Front. Public Health.

[52]  Ingo Borggraefe,et al.  Practical Recommendations for Robot-Assisted Treadmill Therapy (Lokomat) in Children with Cerebral Palsy: Indications, Goal Setting, and Clinical Implementation within the WHO-ICF Framework , 2015, Neuropediatrics.

[53]  T. Platz,et al.  Electromechanical and robot-assisted arm training for improving activities of daily living, arm function, and arm muscle strength after stroke. , 2015, The Cochrane database of systematic reviews.

[54]  Thomas W. J. Janssen,et al.  Recovery of walking ability using a robotic device , 2013 .

[55]  A. Wilcox,et al.  Cohort profile: cerebral palsy in the Norwegian and Danish birth cohorts (MOBAND-CP) , 2016, BMJ Open.

[56]  H. V. van Hedel,et al.  Reliability of timed walking tests and temporo-spatial gait parameters in youths with neurological gait disorders , 2016, BMC Neurology.

[57]  Dae-Hyouk Bang,et al.  Effects of robot-assisted gait training on spatiotemporal gait parameters and balance in patients with chronic stroke: A randomized controlled pilot trial. , 2016, NeuroRehabilitation.

[58]  Rob den Otter,et al.  The combined effects of guidance force, bodyweight support and gait speed on muscle activity during able-bodied walking in the Lokomat. , 2016, Clinical biomechanics.

[59]  V. Arnao,et al.  Stroke incidence, prevalence and mortality in women worldwide , 2016, International journal of stroke : official journal of the International Stroke Society.

[60]  Tabea Aurich-Schuler,et al.  Can Lokomat therapy with children and adolescents be improved? An adaptive clinical pilot trial comparing Guidance force, Path control, and FreeD , 2017, Journal of NeuroEngineering and Rehabilitation.

[61]  K. Musselman,et al.  Training to Improve Walking after Pediatric Spinal Cord Injury: A Systematic Review of Parameters and Walking Outcomes. , 2017, Journal of neurotrauma.

[62]  Cordula Werner,et al.  Electromechanical-assisted training for walking after stroke. , 2017, The Cochrane database of systematic reviews.

[63]  Y. Kerlirzin,et al.  Robotic-assisted gait training improves walking abilities in diplegic children with cerebral palsy. , 2017, European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society.

[64]  L. Cohen,et al.  Biomarkers of stroke recovery: Consensus-based core recommendations from the Stroke Recovery and Rehabilitation Roundtable , 2017, International journal of stroke : official journal of the International Stroke Society.

[65]  WirzMarkus,et al.  Effectiveness of Automated Locomotor Training in Patients with Acute Incomplete Spinal Cord Injury: A Randomized, Controlled, Multicenter Trial. , 2017 .