Sildenafil restores cognitive function without affecting β‐amyloid burden in a mouse model of Alzheimer's disease

BACKGROUND AND PURPOSE Inhibitors of phosphodiesterase 5 (PDE5) affect signalling pathways by elevating cGMP, which is a second messenger involved in processes of neuroplasticity. In the present study, the effects of the PDE5 inhibitor, sildenafil, on the pathological features of Alzheimer's disease and on memory‐related behaviour were investigated.

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