A similarity between viral defense and gene silencing in plants.

Gene silencing in plants, in which an endogenous gene is suppressed by introduction of a related transgene, has been used for crop improvement. Observations that viruses are potentially both initiators and targets of gene silencing suggested that this phenomenon may be related to natural defense against viruses. Supporting this idea, it was found that nepovirus infection of nontransgenic plants induces a resistance mechanism that is similar to transgene-induced gene silencing.

[1]  D. Baulcombe.  Mechanisms of Pathogen-Derived Resistance to Viruses in Transgenic Plants. , 1996, The Plant Cell.

[2]  A. F. Murant,et al.  Seed‐transmission of nematode‐borne viruses , 1967 .

[3]  D. Baulcombe,et al.  Jellyfish green fluorescent protein as a reporter for virus infections. , 1995, The Plant journal : for cell and molecular biology.

[4]  D. Baulcombe,et al.  Ectopic pairing of homologous DNA and post-transcriptional gene silencing in transgenic plants , 1996 .

[5]  S. Covey,et al.  Plants combat infection by gene silencing , 1997, Nature.

[6]  B. Harrison.  Relationship between beet ringspot, potato bouquet and tomato black ring viruses. , 1958, Journal of general microbiology.

[7]  T. Candresse,et al.  The nucleotide sequence of the RNA-2 of an isolate of the English serotype of tomato black ring virus: RNA recombination in the history of nepoviruses. , 1995, The Journal of general virology.

[8]  M. Kumagai,et al.  Cytoplasmic inhibition of carotenoid biosynthesis with virus-derived RNA. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[9]  T. Sijen,et al.  RNA-Mediated Virus Resistance: Role of Repeated Transgenes and Delineation of Targeted Regions. , 1996, The Plant cell.

[10]  W. Dougherty,et al.  Induction of a Highly Specific Antiviral State in Transgenic Plants: Implications for Regulation of Gene Expression and Virus Resistance. , 1993, The Plant cell.

[11]  D. Baulcombe,et al.  Homology‐dependent resistance: transgenic virus resistance in plants related to homology‐dependent gene silencing , 1995 .

[12]  J. Devereux,et al.  A comprehensive set of sequence analysis programs for the VAX , 1984, Nucleic Acids Res..