Compare the therapeutic effectiveness of photodynamic therapy with 980 nm laser on cervical intraepithelial neoplasia

Aim: Cervical intraepithelial neoplasia (CIN) is the precursor of invasive cervical cancer and associated with human papilloma virus (HPV) infection. Standard treatment is conization and may be associated with subsequent pregnancy complications. Laser with wavelength of 980 nm is a treatment choice that can minimize the volume defect of the cervix. Photodynamic therapy (PDT) could targeted destroy the infective tissue and may be an interesting and safety alternative. The aim of this prospective unmatched-cohort study was therefore to compare the therapeutic effectiveness of PDT with 980 nm laser for CIN. Methods: 50 subjects consisted of CIN 1-2 patients treated at the present hospital. 30 patients were treated with PDT and 20 with 980 nm laser. The PDT procedure was irradiation with 630 nm laser (100 mW/cm2, 20 min) 72 h after intravenous injection of Hematoporphyrin derivative (3 mg/kg). 980 nm laser procedure was irradiation cervix with 10 W laser till color of coagulation tissue becoming gray. The cure standard of CIN was that pathological examination or TCT was normal, and HPV clearance rate were observed 3 month later. Results: 27 of the 30 patients (90%) in PDT group and 17 of the 20 patients (85%) in 980 nm laser group were cured. 18 of the 28 patients (64.3%) in PDT group and 11 of the 19 patients (57.9%) in 980 nm laser group HPV test was negative. There were no significant differences in cure rate and HPV clearance rate between PDT and 980 nm laser groups. Conclusions: PDT have same therapeutic effectiveness to 980 nm laser on CIN patients.