Thermo responsive DNA/Polymer Conjugate for Intelligent Antisense Strategy

The conjugate between 20-mer antisense oligodeoxynucleotides (ODN) and thermo-responsive polymer, poly(N-isopropylacrylamide) (PNIPAAm), was prepared. Hybridization reaction between the conjugate and their target RNA was modulated by conformational change of polymer moiety depending on temperature condition.

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