A Nonconventional Approach to Patterned Nanoarrays of DNA Strands for Template-Assisted Assembly of Polyfluorene Nanowires.

DNA molecules have been widely recognized as promising building blocks for constructing functional nanostructures with two main features, that is, self-assembly and rich chemical functionality. The intrinsic feature size of DNA makes it attractive for creating versatile nanostructures. Moreover, the ease of access to tune the surface of DNA by chemical functionalization offers numerous opportunities for many applications. Herein, a simple yet robust strategy is developed to yield the self-assembly of DNA by exploiting controlled evaporative assembly of DNA solution in a unique confined geometry. Intriguingly, depending on the concentration of DNA solution, highly aligned nanostructured fibrillar-like arrays and well-positioned concentric ring-like superstructures composed of DNAs are formed. Subsequently, the ring-like negatively charged DNA superstructures are employed as template to produce conductive organic nanowires on a silicon substrate by complexing with a positively charged conjugated polyelectrolyte poly[9,9-bis(6'-N,N,N-trimethylammoniumhexyl)fluorene dibromide] (PF2) through the strong electrostatic interaction. Finally, a monolithic integration of aligned arrays of DNA-templated PF2 nanowires to yield two DNA/PF2-based devices is demonstrated. It is envisioned that this strategy can be readily extended to pattern other biomolecules and may render a broad range of potential applications from the nucleotide sequence and hybridization as recognition events to transducing elements in chemical sensors.

[1]  P. Björk,et al.  Biomolecular nanowires decorated by organic electronic polymers , 2010 .

[2]  Alexander Hexemer,et al.  Biomimetic self-templating supramolecular structures , 2011, Nature.

[3]  R. Hassanien,et al.  Preparation and characterization of conductive and photoluminescent DNA-templated polyindole nanowires. , 2010, ACS nano.

[4]  P. Björk,et al.  Oligothiophene assemblies defined by DNA interaction: from single chains to disordered clusters. , 2009, Small.

[5]  Faisal A. Aldaye,et al.  Assembling Materials with DNA as the Guide , 2008, Science.

[6]  Kazuhiko Matsumoto,et al.  Novel charge transport in DNA-templated nanowires , 2012 .

[7]  Andrea R Tao,et al.  Spontaneous formation of nanoparticle stripe patterns through dewetting , 2005, Nature materials.

[8]  Hao Yan,et al.  Functional DNA nanotube arrays: bottom-up meets top-down. , 2007, Angewandte Chemie.

[9]  Q. Wang,et al.  Self-assembly of rodlike bio-nanoparticles in capillary tubes. , 2010, Angewandte Chemie.

[10]  Fingerprinting Doesn't Hold Up as a Science in Court , 2002, Science.

[11]  Stela Pruneanu,et al.  Self‐Assembly of DNA‐Templated Polypyrrole Nanowires: Spontaneous Formation of Conductive Nanoropes , 2008 .

[12]  R. Gabrielsson,et al.  Electronic polymers and DNA self-assembled in nanowire transistors. , 2013, Small.

[13]  A. Houlton,et al.  DNA-based routes to semiconducting nanomaterials. , 2009, Chemical communications.

[14]  S Povey,et al.  Dynamic molecular combing: stretching the whole human genome for high-resolution studies. , 1997, Science.

[15]  R. Larson.  Re-shaping the coffee ring. , 2012, Angewandte Chemie.

[16]  DNA-templated nanowires: morphology and electrical conductivity. , 2014, Nanoscale.

[17]  Guojin Zhang,et al.  Polyaniline nanowires on Si surfaces fabricated with DNA templates. , 2004, Journal of the American Chemical Society.

[18]  Kuniaki Nagayama,et al.  Stripe patterns formed on a glass surface during droplet evaporation , 1995 .

[19]  Seok Hee Kang,et al.  A Robust Highly Aligned DNA Nanowire Array-Enabled Lithography for Graphene Nanoribbon Transistors. , 2015, Nano letters.

[20]  Jung-Il Jin,et al.  Materials science of DNA , 2011 .

[21]  Shuguang Zhang.  Fabrication of novel biomaterials through molecular self-assembly , 2003, Nature Biotechnology.

[22]  A. Houlton,et al.  Equilibrium and non-equilibrium thermodynamics of templating reactions for the formation of nanowires , 2012, Nanotechnology.

[23]  Zhiqun Lin,et al.  Drying Mediated Pattern Formation in a Capillary-Held Organometallic Polymer Solution , 2005 .

[24]  G. Whitesides,et al.  Self-Assembly at All Scales , 2002, Science.

[25]  L. J. Lee,et al.  Generating highly ordered DNA nanostrand arrays. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[26]  Feng Qiu,et al.  Self-assembly of gradient concentric rings via solvent evaporation from a capillary bridge. , 2006, Physical review letters.

[27]  Robert A. Barton,et al.  Transfer-printing of single DNA molecule arrays on graphene for high-resolution electron imaging and analysis. , 2011, Nano letters.

[28]  Rajesh R Naik,et al.  Nanomanufacturing of 2D Transition Metal Dichalcogenide Materials Using Self-Assembled DNA Nanotubes. , 2015, Small.

[29]  C. Mirkin,et al.  Synthetically programmable nanoparticle superlattices using a hollow three-dimensional spacer approach. , 2020, Nature nanotechnology.

[30]  Zhiqun Lin,et al.  Learning from "coffee rings": ordered structures enabled by controlled evaporative self-assembly. , 2012, Angewandte Chemie.

[31]  Hyunhyub Ko,et al.  Combing and Bending of Carbon Nanotube Arrays with Confined Microfluidic Flow on Patterned Surfaces , 2004 .

[32]  A. Sokolov,et al.  Direct growth of aligned graphitic nanoribbons from a DNA template by chemical vapour deposition , 2013, Nature Communications.

[33]  Kentaro Tanaka,et al.  A DNA-lipid complex in organic media and formation of an aligned cast film , 1996 .

[34]  L. Ressier,et al.  Tunable conductive nanoparticle wire arrays fabricated by convective self-assembly on nonpatterned substrates. , 2010, ACS nano.

[35]  B. Trask,et al.  A new method for straightening DNA molecules for optical restriction mapping. , 1997, Nucleic acids research.

[36]  Jie Chao,et al.  Dynamic Patterning Programmed by DNA Tiles Captured on a DNA Origami Substrate , 2009, Nature nanotechnology.

[37]  Adam T Woolley,et al.  DNA-templated nanofabrication. , 2009, Chemical Society reviews.

[38]  Ľubor Fraštia,et al.  Dynamical model for the formation of patterned deposits at receding contact lines. , 2010, Physical review letters.

[39]  Michel Calame,et al.  Orientation and Positioning of DNA Molecules with an Electric Field Technique , 2002 .

[40]  M. Lieberman,et al.  Electron-beam lithography and molecular liftoff for directed attachment of DNA nanostructures on silicon: top-down meets bottom-up. , 2014, Accounts of chemical research.

[41]  Samuel I Stupp,et al.  Self-assembly and biomaterials. , 2010, Nano letters.

[42]  T. Dupont,et al.  Capillary flow as the cause of ring stains from dried liquid drops , 1997, Nature.

[43]  F. Simmel,et al.  Polyaniline nanowire synthesis templated by DNA , 2004 .

[44]  G. Bazan,et al.  Control of cationic conjugated polymer performance in light emitting diodes by choice of counterion. , 2006, Journal of the American Chemical Society.

[45]  E. Braun,et al.  DNA-Templated Carbon Nanotube Field-Effect Transistor , 2003, Science.

[46]  J. Carbeck,et al.  Combing of Molecules in Microchannels (COMMIC): A Method for Micropatterning and Orienting Stretched Molecules of DNA on a Surface , 2003 .

[47]  M. Rafailovich,et al.  Drying of DNA droplets. , 2006, Langmuir : the ACS journal of surfaces and colloids.

[48]  P. Björk,et al.  Single molecular imaging and spectroscopy of conjugated polyelectrolytes decorated on stretched aligned DNA. , 2005, Nano letters.

[49]  Zhiqun Lin,et al.  Spontaneous Formation of Mesoscale Polymer Patterns in an Evaporating Bound Solution , 2007 .

[50]  Miguel A. Galindo,et al.  Mechanism of formation of supramolecular DNA-templated polymer nanowires. , 2014, Journal of the American Chemical Society.