Biomolecular imaging and electronic damage using X-ray free-electron lasers

A potentially critical limiting factor in the use of free-electron lasers to determine the structure of organic molecules is the damage the procedure may cause. A model based on coherence theory and quantum electrodynamics suggests that it should be possible to reconstruct a molecule’s structure from the X-ray data obtained as it undergoes damage.

[1]  K. Nugent,et al.  Diffractive imaging using partially coherent x rays. , 2009, Physical review letters.

[2]  Garth J. Williams,et al.  Diffractive imaging using a polychromatic high-harmonic generation soft-x-ray source , 2009 .

[3]  E. Wolf New theory of partial coherence in the space–frequency domain. Part I: spectra and cross spectra of steady-state sources , 1982 .

[4]  Michael Levitt,et al.  Super-resolution biomolecular crystallography with low-resolution data , 2010, Nature.

[5]  A. Ourmazd,et al.  Structure from Fleeting Illumination of Faint Spinning Objects in Flight with Application to Single Molecules , 2008, 0806.2341.

[6]  J. C. Slater Atomic Shielding Constants , 1930 .

[7]  R. London,et al.  Pulse requirements for x-ray diffraction imaging of single biological molecules. , 2005, Physical review. E, Statistical, nonlinear, and soft matter physics.

[8]  G. Faigel,et al.  The effect of tamper layer on the explosion dynamics of atom clusters , 2008, 0807.0111.

[9]  J. Hajdu,et al.  Potential for biomolecular imaging with femtosecond X-ray pulses , 2000, Nature.

[10]  Gábor Oszlányi,et al.  The charge flipping algorithm. , 2008, Acta crystallographica. Section A, Foundations of crystallography.

[11]  W. H. Benner,et al.  Femtosecond diffractive imaging with a soft-X-ray free-electron laser , 2006, physics/0610044.

[12]  J R Fienup,et al.  Phase retrieval algorithms: a comparison. , 1982, Applied optics.

[13]  R. London,et al.  Encapsulation and diffraction-pattern-correction methods to reduce the effect of damage in x-ray diffraction imaging of single biological molecules. , 2007, Physical review letters.

[14]  G. Oszlányi,et al.  Ab initio structure solution by charge flipping. , 2003, Acta crystallographica. Section A, Foundations of crystallography.

[15]  Veit Elser,et al.  Noise Limits on Reconstructing Diffraction Signals From Random Tomographs , 2009, IEEE Transactions on Information Theory.

[16]  Abraham Szoke,et al.  Dynamics of biological molecules irradiated by short x-ray pulses. , 2004, Physical review. E, Statistical, nonlinear, and soft matter physics.

[17]  Gyula Faigel,et al.  Dynamics in a cluster under the influence of intense femtosecond hard X-ray pulses , 2004 .

[18]  S. T. Pratt,et al.  Femtosecond electronic response of atoms to ultra-intense X-rays , 2010, Nature.