Intelligent Mobile Lab for Metabolics in Environmental Monitoring

Abstract The flexible and modular setup of an intelligent mobile lab (IMOLA) that can be equipped with biosensor chips for monitoring of cellular metabolism is described. An application as an environmental monitoring system is described by recording the extracelluar acidification and cellular respiration of Chlorella kessleri after exposure to the herbicide metamitron. The adaptability of the IMOLA system to future developments in the field of biosensors or cellular metabolism analysis is emphasized.

[1]  I-Yu Huang,et al.  Improvement of integrated Ag/AgCl thin-film electrodes by KCl-gel coating for ISFET applications , 2003 .

[2]  S. Zahler,et al.  Dynamic analysis of metabolic effects of chloroacetaldehyde and cytochalasin B on tumor cells using bioelectronic sensor chips , 2005, Journal of Cancer Research and Clinical Oncology.

[3]  Donald G Robertson,et al.  Metabonomics in toxicology: a review. , 2005, Toxicological sciences : an official journal of the Society of Toxicology.

[4]  M. Brischwein,et al.  CELL BASED ASSAYS FOR DIAGNOSTIC AND THERAPY ON MULTIPARAMETRIC BIOSENSOR CHIPS WITH AN INTELLIGENT MOBILE LAB , 2005 .

[5]  Miguel Rodriguez,et al.  Biosensors for rapid monitoring of primary-source drinking water using naturally occurring photosynthesis. , 2002, Biosensors & bioelectronics.

[6]  A. Zehnder,et al.  Factors influencing the growth of Microcystis aeruginosa Kutz, emend, Elenkin. , 1960, Canadian journal of microbiology.

[7]  M. Lehmann,et al.  An ISFET-algal (Chlamydomonas) hybrid provides a system for eco-toxicological tests. , 1999, Biosensors & bioelectronics.

[8]  Bernhard Wolf,et al.  Cellular assays with multiparametric bioelectronic sensor chips , 2005 .

[9]  Claude Durrieu,et al.  Optical whole-cell biosensor using Chlorella vulgaris designed for monitoring herbicides. , 2003, Biosensors & bioelectronics.

[10]  B Wolf,et al.  Functional cellular assays with multiparametric silicon sensor chips. , 2003, Lab on a chip.

[11]  Piet Bergveld,et al.  Thirty years of ISFETOLOGY ☆: What happened in the past 30 years and what may happen in the next 30 years , 2003 .

[12]  J. Ressler,et al.  New concepts for chip-supported multi-well-plates: realization of a 24-well-plate with integrated impedance-sensors for functional cellular screening applications and automated microscope aided cell-based assays , 2004, The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[13]  S. Ardizzone,et al.  Interfacial properties of oxides with technological impact in electrochemistry , 1996 .

[14]  B D DeBusschere,et al.  Portable cell-based biosensor system using integrated CMOS cell-cartridges. , 2001, Biosensors & bioelectronics.

[15]  Ralf Ehret,et al.  Biofunctional hybrid structures—cell–silicon hybrids for applications in biomedicine and bioinformatics , 1998 .