Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor.
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T. Chung | M. Hedrick | E. Sergienko | G. Roth | Derek A. Stonich | S. Vasile | A. Pinkerton | Ying Su | A. Mehta | F. Zeng | E. Sugarman | E. Suyama | Kevin H. Nguyen | Layton H Smith | P. Maloney | M. Milewski | Michael Vicchiarelli | Pasha M. Khan | J. Diwan | Palak Gosalia | Linda Li | Hung Nguyen | A. Novo | A. M. Novo