A Phase 1, Open-Label Study to Evaluate the Effects of Food and Evening Dosing on the Pharmacokinetics of Oral Trofinetide in Healthy Adult Subjects

[1]  W. Kaufmann,et al.  Double-blind, randomized, placebo-controlled study of trofinetide in pediatric Rett syndrome , 2019, Neurology.

[2]  S. Haggarty,et al.  Human cerebral organoids reveal deficits in neurogenesis and neuronal migration in MeCP2-deficient neural progenitors , 2018, Molecular Psychiatry.

[3]  M. Justice,et al.  Rett syndrome: a neurological disorder with metabolic components , 2018, Open Biology.

[4]  O. Della Pasqua,et al.  Population pharmacokinetics of NNZ‐2566 in healthy subjects , 2017, European Journal of Pharmaceutical Sciences.

[5]  W. Kaufmann,et al.  Assessment of Caregiver Inventory for Rett Syndrome , 2017, Journal of Autism and Developmental Disorders.

[6]  Hye-Seung Lee,et al.  The Changing Face of Survival in Rett Syndrome and MECP2-Related Disorders. , 2015, Pediatric neurology.

[7]  M. Rastegar,et al.  Brain Region-Specific Expression of MeCP2 Isoforms Correlates with DNA Methylation within Mecp2 Regulatory Elements , 2014, PloS one.

[8]  H. Leonard,et al.  Trends in the Diagnosis of Rett Syndrome in Australia , 2011, Pediatric Research.

[9]  P. Gluckman,et al.  NNZ-2566: A Gly–Pro–Glu analogue with neuroprotective efficacy in a rat model of acute focal stroke , 2009, Journal of the Neurological Sciences.

[10]  Nathan R. Wilson,et al.  Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice , 2009, Proceedings of the National Academy of Sciences.

[11]  M. Baraldo.  The influence of circadian rhythms on the kinetics of drugs in humans , 2008, Expert opinion on drug metabolism & toxicology.

[12]  Jooil Kim,et al.  Food-Effect Bioavailability and Fed Bioequivalence Studies , 2005 .

[13]  H. Zoghbi,et al.  Rett syndrome and MeCP2: linking epigenetics and neuronal function. , 2002, American journal of human genetics.

[14]  Brahma N. Singh.  Effects of Food on Clinical Pharmacokinetics , 1999, Clinical pharmacokinetics.

[15]  B. Hagberg.  Rett's Syndrome: Prevalence and Impact on Progressive Severe Mental Retardation in Girls , 1985, Acta paediatrica Scandinavica.

[16]  P. Welling,et al.  Influence of food and diet on gastrointestinal drug absorption: A review , 1977, Journal of Pharmacokinetics and Biopharmaceutics.

[17]  A. Yaroshinsky,et al.  A Double-Blind, Randomized, Placebo-Controlled Clinical Study of Trofinetide in the Treatment of Rett Syndrome. , 2017, Pediatric neurology.

[18]  S. Skinner,et al.  Longevity in Rett syndrome: analysis of the North American Database. , 2010, The Journal of pediatrics.

[19]  D. English,et al.  The prevalence and incidence of Rett syndrome in Australia. , 1997, European child & adolescent psychiatry.

[20]  P. Welling,et al.  Effects of food on drug absorption. , 1989, Pharmacology & therapeutics.