rDNA array length is a major determinant of replicative lifespan in budding yeast

Significance Genes encoding ribosomal RNA (rDNA) are organized into a repetitive array in eukaryotic genomes. The copy number of these genes often varies and is responsive to genetics and environment. Here, we show that variation in copy number at the rDNA locus is capable of altering replicative lifespan in yeast. These results indicate that considering rDNA copy number, and conditions that could potentially change this dynamic chromosome locus, is critical for evaluating lifespan. We propose that this rDNA locus represents the kind of repeated element in eukaryotic genomes that escapes easy detection, yet has phenotypic consequences, in this case lifespan.

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