Real-Time EEG Signal Classification for Monitoring and Predicting the Transition Between Different Anaesthetic States

Quantitative identification of the transitions between anaesthetic states is very essential for optimizing patient safety and quality care during surgery but poses a very challenging task. The state-of-the-art monitors are still not capable of providing their manifest variables, so the practitioners must diagnose them based on their own experience. The present paper proposes a novel real-time method to identify these transitions. Firstly, the Hurst method is used to pre-process the de-noised electro-encephalograph (EEG) signals. The maximum of Hurst's ranges is then accepted as the EEG real-time response, which induces a new real-time feature under moving average framework. Its maximum power spectral density is found to be very differentiated into the distinct transitions of anaesthetic states and thus can be used as the quantitative index for their identification.

[1]  Peng Wen,et al.  Consciousness and Depth of Anesthesia Assessment Based on Bayesian Analysis of EEG Signals , 2013, IEEE Transactions on Biomedical Engineering.

[2]  Peggy Mason,et al.  Anesthetic actions within the spinal cord: contributions to the state of general anesthesia , 1995, Trends in Neurosciences.

[3]  W. Hager,et al.  and s , 2019, Shallow Water Hydraulics.

[4]  C.J.D. Pomfrett,et al.  EEG monitoring using bispectral analysis , 1996 .

[5]  N. Franks General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal , 2008, Nature Reviews Neuroscience.

[6]  E R John,et al.  Quantitative EEG changes associated with loss and return of consciousness in healthy adult volunteers anaesthetized with propofol or sevoflurane. , 2001, British journal of anaesthesia.

[7]  W. Marsden I and J , 2012 .

[8]  L. Voss,et al.  Using Permutation Entropy to Measure the Electroencephalographic Effects of Sevoflurane , 2008, Anesthesiology.

[9]  S. Dudoit,et al.  Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. , 2002, Nucleic acids research.

[10]  B. Orser,et al.  Inhaled Anesthetics and Immobility: Mechanisms, Mysteries, and Minimum Alveolar Anesthetic Concentration , 2003, Anesthesia and analgesia.

[11]  B. Antkowiak,et al.  Molecular and neuronal substrates for general anaesthetics , 2004, Nature Reviews Neuroscience.

[12]  F. Chung,et al.  A post-anesthetic discharge scoring system for home readiness after ambulatory surgery. , 1995, Journal of clinical anesthesia.

[13]  Martin T. Wells,et al.  Bayesian Normalization and Identification for Differential Gene Expression Data , 2005, J. Comput. Biol..

[14]  S. Kreuer,et al.  The Narcotrend monitor. , 2006, Best practice & research. Clinical anaesthesiology.

[15]  R. Sarpong,et al.  Bio-inspired synthesis of xishacorenes A, B, and C, and a new congener from fuscol† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc02572c , 2019, Chemical science.

[16]  K. Miller,et al.  Mechanisms of actions of inhaled anesthetics. , 2003, The New England journal of medicine.

[17]  P. Welch The use of fast Fourier transform for the estimation of power spectra: A method based on time averaging over short, modified periodograms , 1967 .

[18]  W. R. Lieb,et al.  Molecular and cellular mechanisms of general anaesthesia , 1994, Nature.

[19]  J A Aldrete,et al.  A Postanesthetic Recovery Score , 1970, Anesthesia and analgesia.

[20]  R. Chabot,et al.  Patient state index. , 2002, Best practice & research. Clinical anaesthesiology.

[21]  Denise McGrath,et al.  Fractals , 2018, Nonlinear Analysis for Human Movement Variability.

[22]  G. Volgyesi,et al.  Stabilometry: A new tool for the measurement of recovery following general anaesthesia for out-patients , 1978, Canadian Anaesthetists' Society journal.

[23]  J. Kanusky,et al.  Stunning the neural nexus: mechanisms of general anesthesia. , 2004, AANA journal.

[24]  Yan Li,et al.  Measuring and Reflecting Depth of Anesthesia Using Wavelet and Power Spectral Density , 2011, IEEE Transactions on Information Technology in Biomedicine.

[25]  D. Galletly,et al.  Level of consciousness on arrival in the recovery room and the development of early respiratory morbidity. , 1992, Anaesthesia and Intensive Care.

[26]  Yan Li,et al.  Monitoring the depth of anaesthesia using Hurst exponent and Bayesian methods , 2014, IET Signal Process..

[27]  A. Yli-Hankala,et al.  Description of the Entropy™ algorithm as applied in the Datex‐Ohmeda S/5™ Entropy Module , 2004, Acta anaesthesiologica Scandinavica.

[28]  B. Urban Current assessment of targets and theories of anaesthesia. , 2002, British journal of anaesthesia.