Voltage Amplifier Based on Organic Electrochemical Transistor

Organic electrochemical transistors (OECTs) are receiving a great deal of attention as amplifying transducers for electrophysiology. A key limitation of this type of transistors, however, lies in the fact that their output is a current, while most electrophysiology equipment requires a voltage input. A simple circuit is built and modeled that uses a drain resistor to produce a voltage output. It is shown that operating the OECT in the saturation regime provides increased sensitivity while maintaining a linear signal transduction. It is demonstrated that this circuit provides high quality recordings of the human heart using readily available electrophysiology equipment, paving the way for the use of OECTs in the clinic.

[1]  George G. Malliaras,et al.  Direct patterning of organic conductors on knitted textiles for long-term electrocardiography , 2015, Scientific Reports.

[2]  Patrick E. McSharry,et al.  Advanced Methods And Tools for ECG Data Analysis , 2006 .

[3]  Jonathan Rivnay,et al.  Ion‐Selective Organic Electrochemical Transistors , 2014, Advanced materials.

[4]  C. Koch,et al.  The origin of extracellular fields and currents — EEG, ECoG, LFP and spikes , 2012, Nature Reviews Neuroscience.

[5]  P. Leleux,et al.  In vivo recordings of brain activity using organic transistors , 2013, Nature Communications.

[6]  A. Bonfiglio,et al.  Electrical characteristics of ink-jet printed, all-polymer electrochemical transistors , 2012 .

[7]  S. Shaheen,et al.  Optical Measurements Revealing Nonuniform Hole Mobility in Organic Electrochemical Transistors , 2015 .

[8]  P. Leleux,et al.  High transconductance organic electrochemical transistors , 2013, Nature Communications.

[9]  Christophe Bernard,et al.  High-performance transistors for bioelectronics through tuning of channel thickness , 2015, Science Advances.

[10]  Jonathan Rivnay,et al.  Combined Optical and Electronic Sensing of Epithelial Cells Using Planar Organic Transistors , 2014, Advanced materials.

[11]  C Zywietz,et al.  Stability of computer ECG amplitude measurements in the presence of noise. The CSE Working Party. , 1990, Computers and biomedical research, an international journal.

[12]  George G. Malliaras,et al.  Steady‐State and Transient Behavior of Organic Electrochemical Transistors , 2007 .

[13]  Jonathan Rivnay,et al.  Organic Electrochemical Transistors with Maximum Transconductance at Zero Gate Bias , 2013, Advanced materials.

[14]  Christian Bénar,et al.  Organic Electrochemical Transistors for Clinical Applications , 2015, Advanced healthcare materials.

[15]  R. E. Mason,et al.  A new system of multiple-lead exercise electrocardiography. , 1966, American heart journal.

[16]  M. Heuzey,et al.  Ionic liquid–water mixtures and ion gels as electrolytes for organic electrochemical transistors , 2015 .

[17]  Manfred Lindau,et al.  Direct Measurement of Ion Mobility in a Conducting Polymer , 2013, Advanced materials.

[18]  D. Khodagholy,et al.  Easy‐to‐Fabricate Conducting Polymer Microelectrode Arrays , 2013, Advanced materials.

[19]  Nikolaos G. Bourbakis,et al.  A Survey on Wearable Sensor-Based Systems for Health Monitoring and Prognosis , 2010, IEEE Transactions on Systems, Man, and Cybernetics, Part C (Applications and Reviews).

[20]  H. White,et al.  CHEMICAL DERIVATIZATION OF MICROELECTRODE ARRAYS BY OXIDATION OF PYRROLE AND N-METHYLPYRROLE: FABRICATION OF MOLECULE-BASED ELECTRONIC DEVICES. , 1984 .

[21]  S. Chou,et al.  Relationship between measured and intrinsic transconductances of FET's , 1987, IEEE Transactions on Electron Devices.

[22]  J. Webster.  Reducing Motion Artifacts and Interference in Biopotential Recording , 1984, IEEE Transactions on Biomedical Engineering.

[23]  Andrea Ridolfi,et al.  BIOTEX—Biosensing Textiles for Personalised Healthcare Management , 2010, IEEE Transactions on Information Technology in Biomedicine.

[24]  Feng Yan,et al.  Organic Electrochemical Transistors Integrated in Flexible Microfluidic Systems and Used for Label‐Free DNA Sensing , 2011, Advanced materials.

[25]  David Nilsson,et al.  Bi-stable and dynamic current modulation in electrochemical organic transistors , 2002 .

[26]  D. Tucker,et al.  Scalp electrode impedance, infection risk, and EEG data quality , 2001, Clinical Neurophysiology.

[27]  M. Berggren,et al.  Electronic control of Ca2+ signalling in neuronal cells using an organic electronic ion pump. , 2007, Nature materials.

[28]  Peter Andersson,et al.  Active Matrix Displays Based on All‐Organic Electrochemical Smart Pixels Printed on Paper , 2002 .

[29]  Feng Yan,et al.  Highly Sensitive Glucose Biosensors Based on Organic Electrochemical Transistors Using Platinum Gate Electrodes Modified with Enzyme and Nanomaterials , 2011 .

[30]  Daniel Moses,et al.  Electrochemical doping in electrolyte-gated polymer transistors. , 2007, Journal of the American Chemical Society.

[31]  M. Berggren,et al.  Electrocardiographic Recording with Conformable Organic Electrochemical Transistor Fabricated on Resorbable Bioscaffold , 2014, Advanced materials.

[32]  George G. Malliaras,et al.  The Rise of Organic Bioelectronics , 2014 .

[33]  Joseph Varon,et al.  Einthoven's string galvanometer: the first electrocardiograph. , 2008, Texas Heart Institute journal.

[34]  David Nilsson,et al.  An all-organic sensor-transistor based on a novel electrochemical transducer concept printed electrochemical sensors on paper , 2002 .