Covalent linkage of recombinant hirudin to poly(ethylene terephthalate) (Dacron): creation of a novel antithrombin surface.

[1]  O. H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[2]  D. Lyman,et al.  Interactions at the blood-polymer interface. , 1971, Federation proceedings.

[3]  P. Majerus,et al.  The binding of thrombin to the surface of human platelets. , 1974, The Journal of biological chemistry.

[4]  R. Rosenberg,et al.  Effect of heparin and heparin fractions on platelet aggregation. , 1980, The Journal of clinical investigation.

[5]  J. Pouysségur,et al.  Hirudin, a probe to analyze the growth-promoting activity of thrombin in fibroblasts; reevaluation of the temporal action of competence factors. , 1982, Biochemical and biophysical research communications.

[6]  D. Beeler,et al.  Purification and properties of human platelet heparitinase. , 1982, The Journal of biological chemistry.

[7]  J. Feijen,et al.  Covalently bound conjugates of albumin and heparin: synthesis, fractionation and characterization. , 1983, Thrombosis research.

[8]  R. Bar-Shavit,et al.  Monocyte chemotaxis: stimulation by specific exosite region in thrombin. , 1983, Science.

[9]  C. Wildevuur,et al.  The thrombogenic characteristics of small caliber polyurethane vascular prostheses after heparin bonding. , 1985, Transactions - American Society for Artificial Internal Organs.

[10]  F. Markwardt Pharmacology of hirudin: one hundred years after the first report of the anticoagulant agent in medicinal leeches. , 1985, Biomedica biochimica acta.

[11]  E. Merrill,et al.  Catalytic activity and platelet reactivity of heparin covalently bonded to surfaces. , 1985, The Journal of laboratory and clinical medicine.

[12]  V. Torchilin,et al.  Water-soluble urokinase derivatives of combined action. , 1985, Thrombosis research.

[13]  G F Anderson,et al.  Responses of Aortic Smooth Muscle to Thrombin and Thrombin Analogues a , 1986, Annals of the New York Academy of Sciences.

[14]  J. Wilson Hemocompatible polymers: preparation and properties , 1986 .

[15]  S. W. Kim,et al.  In vitro bioactivity of a synthesized prostaglandin E1-heparin conjugate. , 1986, Journal of pharmaceutical sciences.

[16]  D. Bing,et al.  Thrombin Active-Site Regions , 1986, Seminars in thrombosis and hemostasis.

[17]  R. Bizios,et al.  Thrombin‐induced chemotaxis and aggregation of neutrophils , 1986, Journal of cellular physiology.

[18]  L V McIntire,et al.  Platelet active concentration profiles near growing thrombi. A mathematical consideration. , 1986, Biophysical journal.

[19]  R. Guidoin,et al.  Characteristics of polyester arterial grafts coated with albumin: the role and importance of the cross-linking chemicals. , 1988, European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes.

[20]  In vivo evaluation of polyester arterial grafts coated with albumin: the role and importance of cross-linking agents. , 1988, European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes.

[21]  T. Okano,et al.  Heparin immobilization onto segmented polyurethane-urea surfaces--effect of hydrophilic spacers. , 1988, Journal of biomedical materials research.

[22]  J. Feijen,et al.  Synthesis and Characterization of Polystyrene-Poly( Ethylene Oxide) -Heparin Block Copolymers , 1988 .

[23]  Y. Ito,et al.  In vitro platelet adhesion and in vivo antithrombogenicity of heparinized polyetherurethaneureas. , 1988, Biomaterials.

[24]  J W Fenton,et al.  Regulation of Thrombin Generation and Functions , 1988, Seminars in thrombosis and hemostasis.

[25]  P. del Vecchio,et al.  Platelets adhere to thrombin-treated endothelial cells in vitro. , 1989, The American journal of physiology.

[26]  R. Guidoin,et al.  Cellular reactions to polyester arterial prostheses impregnated with cross-linked albumin: in vivo studies in mice. , 1989, Biomaterials.

[27]  J. S. Clarke,et al.  The influence of early surface thromboreactivity on long-term arterial graft patency. , 1989, Surgery.

[28]  L V McIntire,et al.  Mathematical analysis of mural thrombogenesis. Concentration profiles of platelet-activating agents and effects of viscous shear flow. , 1989, Biophysical journal.

[29]  P. Hogg,et al.  Fibrin monomer protects thrombin from inactivation by heparin-antithrombin III: implications for heparin efficacy. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[30]  E. Merrill,et al.  Activity toward thrombin-antithrombin of heparin immobilized on two hydrogels. , 1989, Biomaterials.

[31]  J. Anderson,et al.  Effect of albumin coating on the in vitro blood compatibility of Dacron arterial prostheses. , 1989, Biomaterials.

[32]  D. Massel,et al.  Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors. , 1990, The Journal of clinical investigation.

[33]  In vivo nonthrombogenicity of heparin immobilized polymer surfaces. , 1990, ASAIO transactions.

[34]  R. Huber,et al.  The structure of a complex of recombinant hirudin and human alpha-thrombin. , 1990, Science.

[35]  B. van der Lei,et al.  Reduced thrombogenicity of artificial materials by coating with ADPase. , 1991, Biomaterials.

[36]  S. Mohammad,et al.  Heparin binding on poly(L-lysine) immobilized surface , 1991 .

[37]  Heparin immobilization increased through chemical amplification. , 1991, Journal of biomedical materials research.

[38]  V. I. Sevastianov,et al.  The interaction of heparinized biomaterials with human serum, albumin, fibrinogen, antithrombin III, and platelets. , 2008, Artificial organs.

[39]  S. Cooper,et al.  Anticoagulant effects of sulphonated polyurethanes. , 1992, Biomaterials.

[40]  Y. Ito,et al.  Cell growth on immobilized cell growth factor. I. Acceleration of the growth of fibroblast cells on insulin-immobilized polymer matrix in culture medium without serum. , 1992, Biomaterials.

[41]  G. Elgue,et al.  On the Mechanism of Coagulation Inhibition on Surfaces with End Point Immobilized Heparin , 1993, Thrombosis and Haemostasis.

[42]  M. Akashi,et al.  Immobilization of human thrombomodulin onto poly(ether urethane urea) for developing antithrombogenic blood-contacting materials. , 1994, Biomaterials.

[43]  M. Phaneuf,et al.  Covalent Linkage of Streptokinase to Recombinant Hirudin: A Novel Thrombolytic Agent with Antithrombotic Properties , 1994, Thrombosis and Haemostasis.

[44]  M. Phaneuf,et al.  Synthesis and characterization of a recombinant hirudin-albumin complex. , 1994, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

[45]  Y. Ito,et al.  Cell growth on immobilized cell-growth factor. 10. Insulin and polyallylamine co-immobilized materials. , 1994, Biomaterials.

[46]  R. Barbucci,et al.  Conformation of human plasma proteins at polymer surfaces: the effectiveness of surface heparinization. , 1994, Biomaterials.

[47]  M. Phaneuf,et al.  Modification of polyethylene terephthalate (Dacron) via denier reduction: effects on material tensile strength, weight, and protein binding capabilities. , 1995, Journal of applied biomaterials : an official journal of the Society for Biomaterials.

[48]  P D Verdouw,et al.  Reduction in thrombotic events with heparin-coated Palmaz-Schatz stents in normal porcine coronary arteries. , 1996, Circulation.