Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons

[1]  T. Wollert.  Autophagy , 2019, Current Biology.

[2]  A. Hjelmeland,et al.  Metabolic, autophagic, and mitophagic activities in cancer initiation and progression , 2016, Biomedical journal.

[3]  Jianhua Zhang,et al.  The Role of Autophagy, Mitophagy and Lysosomal Functions in Modulating Bioenergetics and Survival in the Context of Redox and Proteotoxic Damage: Implications for Neurodegenerative Diseases , 2016, Aging and disease.

[4]  S. Velu,et al.  Mitochondrial thiol modification by a targeted electrophile inhibits metabolism in breast adenocarcinoma cells by inhibiting enzyme activity and protein levels , 2016, Redox biology.

[5]  S. Velu,et al.  Mitochondrial thiol modi fi cation by a targeted electrophile inhibits metabolism in breast adenocarcinoma cells by inhibiting enzyme activity and protein levels , 2016 .

[6]  M. Kindy,et al.  Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate , 2015, Front. Neurol..

[7]  M. Nonnenmacher,et al.  High-dose chloroquine is metabolically cardiotoxic by inducing lysosomes and mitochondria dysfunction in a rat model of pressure overload hypertrophy , 2015, Physiological reports.

[8]  S. Ghavami,et al.  Suppression of influenza A virus replication in human lung epithelial cells by noncytotoxic concentrations bafilomycin A1. , 2015, American journal of physiology. Lung cellular and molecular physiology.

[9]  Jianhua Zhang.  Teaching the basics of autophagy and mitophagy to redox biologists—Mechanisms and experimental approaches , 2015, Redox biology.

[10]  S. Ravi,et al.  Bioenergetic adaptation in response to autophagy regulators during rotenone exposure , 2014, Journal of neurochemistry.

[11]  Edward T Chouchani,et al.  Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS , 2014, Nature.

[12]  Jianhua Zhang,et al.  Mitophagy mechanisms and role in human diseases. , 2014, The international journal of biochemistry & cell biology.

[13]  Jianhua Zhang,et al.  The role of GABARAPL1/GEC1 in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cells , 2014, Autophagy.

[14]  B. Hill,et al.  Comprehensive measurement of respiratory activity in permeabilized cells using extracellular flux analysis , 2014, Nature Protocols.

[15]  M. Kindy,et al.  Brain pyroglutamate amyloid-β is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeutic. , 2014, Journal of Alzheimer's disease : JAD.

[16]  Jianhua Zhang,et al.  Inhibition of autophagy and glycolysis by nitric oxide during hypoxia-reoxygenation impairs cellular bioenergetics and promotes cell death in primary neurons. , 2013, Free radical biology & medicine.

[17]  J. Gisbert,et al.  Azathioprine desensitizes liver cancer cells to insulin-like growth factor 1 and causes apoptosis when it is combined with bafilomycin A1. , 2013, Toxicology and applied pharmacology.

[18]  Jianhua Zhang,et al.  Cellular metabolic and autophagic pathways: traffic control by redox signaling. , 2013, Free radical biology & medicine.

[19]  N. Fineberg,et al.  Inhibition of glycolysis attenuates 4-hydroxynonenal-dependent autophagy and exacerbates apoptosis in differentiated SH-SY5Y neuroblastoma cells , 2013, Autophagy.

[20]  D. Gius,et al.  Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts. , 2013, The Biochemical journal.

[21]  S. Ballinger,et al.  Developmental Exposure to Second-Hand Smoke Increases Adult Atherogenesis and Alters Mitochondrial DNA Copy Number and Deletions in apoE−/− Mice , 2013, PloS one.

[22]  Jianhua Zhang.  Autophagy and mitophagy in cellular damage control☆ , 2013, Redox biology.

[23]  S. Ballinger,et al.  Convergent mechanisms for dysregulation of mitochondrial quality control in metabolic disease: implications for mitochondrial therapeutics. , 2013, Biochemical Society transactions.

[24]  Y. Isaka,et al.  Chloroquine in cancer therapy: a double-edged sword of autophagy. , 2013, Cancer research.

[25]  J. Lancaster,et al.  Integration of cellular bioenergetics with mitochondrial quality control and autophagy , 2012, Biological chemistry.

[26]  Kevin W Eliceiri,et al.  NIH Image to ImageJ: 25 years of image analysis , 2012, Nature Methods.

[27]  Robert Clarke,et al.  Guidelines for the use and interpretation of assays for monitoring autophagy , 2012 .

[28]  Jianhua Zhang,et al.  Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling , 2011, The Biochemical journal.

[29]  A. Landar,et al.  Assessing bioenergetic function in response to oxidative stress by metabolic profiling. , 2011, Free radical biology & medicine.

[30]  A. Schapira,et al.  Mitochondrial Contribution to Parkinson's Disease Pathogenesis , 2011, Parkinson's disease.

[31]  Brian J. Bennett,et al.  Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease , 2011, Nature.

[32]  M. Kindy,et al.  The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activity. , 2011, Journal of Alzheimer's disease : JAD.

[33]  Ruslan I. Dmitriev,et al.  Bafilomycin A1 activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondria , 2010, Cellular and Molecular Life Sciences.

[34]  Stanley L Hazen,et al.  Targeted Metabolomic Evaluation of Arginine Methylation and Cardiovascular Risks: Potential Mechanisms Beyond Nitric Oxide Synthase Inhibition , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[35]  M. Komatsu,et al.  Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy , 2009, Aging.

[36]  P. Seglen,et al.  Does bafilomycin A1 block the fusion of autophagosomes with lysosomes? , 2008, Autophagy.

[37]  A. Kudin,et al.  Mitochondrial dysfunction in neurodegenerative disorders. , 2007, Biochemical Society transactions.

[38]  M. Salkinoja-Salonen,et al.  Bafilomycin A1 is a potassium ionophore that impairs mitochondrial functions , 2007, Journal of bioenergetics and biomembranes.

[39]  N. Mizushima,et al.  How to Interpret LC3 Immunoblotting , 2007, Autophagy.

[40]  R. Johnson,et al.  Bafilomycin Induces the p21-Mediated Growth Inhibition of Cancer Cells under Hypoxic Conditions by Expressing Hypoxia-Inducible Factor-1α , 2006, Molecular Pharmacology.

[41]  Yoshihiro,et al.  Bafilomycin Ai Prevents Maturation of Autophagic Vacuoles by Inhibiting Fusion between Autophagosomesand Lysosomes in Rat HepatomaCell Line , H-4-IIE Cells , 2006 .

[42]  D. Klionsky,et al.  Autophagy: molecular machinery for self-eating , 2005, Cell Death and Differentiation.

[43]  J. Marín-García,et al.  Mitochondrial signaling pathways: A receiver/integrator organelle , 2004, Molecular and Cellular Biochemistry.

[44]  N. Avadhani,et al.  Mitochondrial signaling: the retrograde response. , 2004, Molecular cell.

[45]  D. Rast,et al.  Metabolic products of microorganisms , 1981, Archives of Microbiology.

[46]  Sudhir Gupta,et al.  Molecular signaling in death receptor and mitochondrial pathways of apoptosis (Review). , 2003, International journal of oncology.

[47]  S. Ballinger,et al.  Cigarette Smoke Exposure and Hypercholesterolemia Increase Mitochondrial Damage in Cardiovascular Tissues , 2002, Circulation.

[48]  S. Emr,et al.  Autophagy as a regulated pathway of cellular degradation. , 2000, Science.

[49]  Takeshi Noda,et al.  LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing , 2000, The EMBO journal.

[50]  E. Lagarde,et al.  Impact of chloroquine resistance on malaria mortality. , 1998, Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie.

[51]  T. Terada,et al.  Bafilomycin A1 induces apoptosis in the human pancreatic cancer cell line Capan‐1 , 1998, The Journal of pathology.

[52]  Y. Moriyama,et al.  Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. , 1998, Cell structure and function.

[53]  H. Ochiai,et al.  Inhibitory effect of bafilomycin A1, a specific inhibitor of vacuolar-type proton pump, on the growth of influenza A and B viruses in MDCK cells. , 1995, Antiviral research.

[54]  A. Cerami,et al.  Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoites , 1992, Nature.

[55]  Y. Moriyama,et al.  Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells. , 1991, The Journal of biological chemistry.

[56]  K. Altendorf,et al.  Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[57]  H. Zähner,et al.  METABOLIC PRODUCTS OF MICROORGANISMS. 224 , 1984 .

[58]  H. Zähner,et al.  Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity. , 1984, The Journal of antibiotics.

[59]  D. Warhurst,et al.  Lysosomes, pH and the Anti-malarial Action of Chloroquine , 1972, Nature.

[60]  J. Błasiak,et al.  Redox Biology , 2018 .