Concomitant Guillain Barre Syndrome and Transverse Myelitis as Initial Neuropsychiatric Manifestation in a Case of Lupus: A Diagnostic Quandary

Neuropsychiatric manifestations of systemic lupus erythematosus are varied. Presently nineteen in number, they are classified as whether affecting the central or the peripheral compartments of the nervous system. Its diagnosis however remains difficult, more so when two or more of the syndromes are found concomitantly in the same patient and when they occur in absence of the more classical rash, serositis, and haematological manifestations. We present a case of lupus where myelopathy as well as demyelination existed simultaneously as the initial neurologic manifestation.

[1]  J. Branco,et al.  Classification of Systemic Lupus Erythematosus: Systemic Lupus International Collaborating Clinics Versus American College of Rheumatology Criteria. A Comparative Study of 2,055 Patients From a Real‐Life, International Systemic Lupus Erythematosus Cohort , 2015, Arthritis care & research.

[2]  L. Amezcua-Guerra,et al.  Performance of the 2012 Systemic Lupus International Collaborating Clinics and the 1997 American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus in a Real‐Life Scenario , 2015, Arthritis care & research.

[3]  N. Damjanov SP0151 Comorbidity in Rheumatic Diseases , 2014 .

[4]  A. G. Helg What and what not to conclude from the results of the LEGS study? , 2014, Annals of the rheumatic diseases.

[5]  S. Saip,et al.  A2.7 Concomitant transverse myelitis and guillain-barre syndrome after adalimumab therapy in a case with ankylosing spondylitis , 2014 .

[6]  Y. Shoenfeld,et al.  International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS) , 2006, Journal of thrombosis and haemostasis : JTH.

[7]  K. Scherer Neurologic Manifestations of Vitamin B12 Deficiency , 2003 .

[8]  P. Rose,et al.  Acute transverse myelitis and Guillain–Barré overlap syndrome with serological evidence for mumps viraemia , 2001, Acta neurologica Scandinavica.

[9]  Caroline Gordon,et al.  The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes. , 1999, Arthritis and rheumatism.

[10]  H T Mount,et al.  Multiple sclerosis and other demyelinating diseases. , 1973, Canadian Medical Association journal.

[11]  E. Rodríguez [Neurologic manifestations of vitamin B12 deficiency]. , 1965, Revista de neuro-psiquiatria.

[12]  B. Stern,et al.  Neurologic manifestations of sarcoidosis. , 2014, Handbook of clinical neurology.

[13]  H. Guleryuz,et al.  Coexistence of myositis, transverse myelitis, and Guillain Barré syndrome following Mycoplasma pneumoniae infection in an adolescent , 2013, Journal of pediatric neurosciences.

[14]  J. Hanly The Nervous System and Lupus , 2011 .

[15]  F. Dubas [Neurologic manifestations of sarcoidosis]. , 1988, La Revue de medecine interne.