Catalytic and molecular insights of the esterification of ibuprofen and ketoprofen with glycerol

[1]  E. Tamburini,et al.  Biocatalytic Approach for Direct Esterification of Ibuprofen with Sorbitol in Biphasic Media , 2021, International journal of molecular sciences.

[2]  E. Guadix,et al.  Novozyme 435 and Lipozyme RM IM Preferably Esterify Polyunsaturated Fatty Acids at the sn‐2 Position , 2020 .

[3]  M. L. Ferreira,et al.  Valorization of Glycerol through the Enzymatic Synthesis of Acylglycerides with High Nutritional Value , 2020, Catalysts.

[4]  S. Collins,et al.  Influence of Water on Enzymatic Esterification of Racemic Ketoprofen with Ethanol in a Solvent-Free System , 2019, Topics in Catalysis.

[5]  O. Barbosa,et al.  Novozym 435: the “perfect” lipase immobilized biocatalyst? , 2019, Catalysis Science & Technology.

[6]  L. Briand,et al.  Relevance and bio-catalytic strategies for the kinetic resolution of ketoprofen towards dexketoprofen , 2018, Critical reviews in biotechnology.

[7]  M. L. Ferreira,et al.  Molecular recognition of an acyl–enzyme intermediate on the lipase B from Candida antarctica , 2017 .

[8]  C. Berli,et al.  ATR-FTIR Spectrokinetic Analysis of the CO Adsorption and Oxidation at Water/Platinum Interface , 2017 .

[9]  V. Pârvulescu,et al.  Enhancement of the valorization of renewable glycerol: The effects of the surfactant-enzyme interaction on the biocatalytic synthesis of glycerol carbonate , 2017 .

[10]  L. Briand,et al.  Enzymatic kinetic resolution of racemic ibuprofen: past, present and future , 2016, Critical reviews in biotechnology.

[11]  F. García-Ochoa,et al.  Enzymatic synthesis of ibuprofen monoglycerides catalyzed by free Candida antarctica lipase B in a toluene–glycerol biphasic medium , 2016 .

[12]  B. Rigas,et al.  The novel agent phospho-glycerol-ibuprofen-amide (MDC-330) inhibits glioblastoma growth in mice: an effect mediated by cyclin D1. , 2016, Carcinogenesis.

[13]  M. L. Ferreira,et al.  An insight on acyl migration in solvent-free ethanolysis of model triglycerides using Novozym 435. , 2016, Journal of biotechnology.

[14]  F. García-Ochoa,et al.  Esterification of glycerol and ibuprofen in solventless media catalyzed by free CALB: Kinetic modelling , 2015 .

[15]  M. L. Ferreira,et al.  Towards a green enantiomeric esterification of R/S-ketoprofen: a theoretical and experimental investigation , 2015 .

[16]  M. Takano,et al.  The influence of chronic ibuprofen treatment on proteins expressed in the mouse hippocampus. , 2015, European journal of pharmacology.

[17]  Ahmad Zuhairi Abdullah,et al.  Dealing with the surplus of glycerol production from biodiesel industry through catalytic upgrading to polyglycerols and other value-added products , 2014 .

[18]  J. Zaro Lipid-Based Drug Carriers for Prodrugs to Enhance Drug Delivery , 2014, The AAPS Journal.

[19]  L. Briand,et al.  Analytical characterization and purification of a commercial extract of enzymes: a case study. , 2014, Colloids and surfaces. B, Biointerfaces.

[20]  Dahai Yu,et al.  A concentration-dependent effect of methanol on Candida antarctica lipase B in aqueous phase , 2014 .

[21]  Pablo A. Kler,et al.  Design and operational limits of an ATR-FTIR spectroscopic microreactor for investigating reactions at liquid–solid interface , 2014 .

[22]  Manuel Marino Ignacio Feria Rodríguez Fármacos analgésicos antipiréticos y antiinflamatorios no esteroideos: antiartríticos , 2014 .

[23]  M. L. Ferreira,et al.  Esterification of R/S-ketoprofen with 2-propanol as reactant and solvent catalyzed by Novozym® 435 at selected conditions , 2012 .

[24]  M. L. Ferreira,et al.  FTIR-ATR characterization of free Rhizomucor meihei lipase (RML), Lipozyme RM IM and chitosan-immobilized RML , 2011 .

[25]  M. L. Ferreira,et al.  Investigation of the causes of deactivation–degradation of the commercial biocatalyst Novozym® 435 in ethanol and ethanol–aqueous media , 2011 .

[26]  H. Treichel,et al.  Successive cycles of utilization of novozym 435 in three different reaction systems , 2011 .

[27]  S. Tsai,et al.  Lipase-catalyzed alcoholytic resolution of (R,S)-flurbiprofenyl azolides for preparation of (R)-NO-flurbiprofen ester prodrugs , 2011 .

[28]  N. Wang,et al.  Biocatalytic synthesis and in vitro release of biodegradable linear polyesters with pendant ketoprofen. , 2010, Biomacromolecules.

[29]  Raffaele Morrone,et al.  Biocatalyzed irreversible esterification in the preparation of S-naproxen , 2010 .

[30]  Qiang Li,et al.  Dependence on the properties of organic solvent: study on acyl migration kinetics of partial glycerides. , 2010, Bioresource technology.

[31]  Silvia Herranz,et al.  Profármacos: pasado,presente y futuro , 2010 .

[32]  Wei Du,et al.  The solvent influence on the positional selectivity of Novozym 435 during 1,3-diolein synthesis by esterification. , 2010, Bioresource technology.

[33]  M. L. Ferreira,et al.  Enantioselective esterification of ibuprofen with ethanol as reactant and solvent catalyzed by immobilized lipase: experimental and molecular modeling aspects , 2009 .

[34]  P. Murumkar,et al.  Prodrug designing of NSAIDs. , 2009, Mini reviews in medicinal chemistry.

[35]  G. Carrea,et al.  Can an inactivating agent increase enzyme activity in organic solvent? Effects of 18‐crown‐6 on lipase activity, enantioselectivity, and conformation , 2007, Biotechnology and bioengineering.

[36]  W. Buchanan,et al.  The use of NSAIDs in rheumatic disorders 2005: a global perspective , 2005, InflammoPharmacology.

[37]  Hani Doss,et al.  Aspirin, ibuprofen, and other non-steroidal anti-inflammatory drugs in cancer prevention: a critical review of non-selective COX-2 blockade (review). , 2005, Oncology reports.

[38]  A. Barth,et al.  What vibrations tell about proteins , 2002, Quarterly Reviews of Biophysics.

[39]  RA Pascucci Use of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 (COX-2) inhibitors: indications and complications , 2002, The Journal of the American Osteopathic Association.

[40]  U. P. Fringeli,et al.  Quantitative modulated excitation Fourier transform infrared spectroscopy , 2001 .

[41]  G. Coruzzi,et al.  A new class of ibuprofen derivatives with reduced gastrotoxicity. , 2001, Journal of medicinal chemistry.

[42]  Per Berglund Controlling lipase enantioselectivity for organic synthesis. , 2001, Biomolecular engineering.

[43]  S. Tsai,et al.  Enantioselective Synthesis of (S)‐Ibuprofen Ester Prodrug in Cyclohexane by Candida rugosa Lipase Immobilized on Accurel MP1000 , 2000, Biotechnology progress.

[44]  L. Demetrius Role of enzyme-substrate flexibility in catalytic activity: an evolutionary perspective. , 1998, Journal of theoretical biology.

[45]  A. Padt,et al.  Lipase Mediated Resolution of γ-Branched Chain Fatty Acid Methyl Esters , 1998 .

[46]  Kurt Faber,et al.  Biotransformations in Organic Chemistry , 1992 .

[47]  Shih-Hsiung Wu,et al.  Quantitative analyses of biochemical kinetic resolution of enantiomers. 2. Enzyme-catalyzed esterifications in water-organic solvent biphasic systems , 1987 .

[48]  L. Riechmann,et al.  Equilibrium and kinetically controlled synthesis with enzymes: semisynthesis of penicillins and peptides. , 1987, Methods in enzymology.

[49]  C. Sih,et al.  Quantitative analyses of biochemical kinetic resolutions of enantiomers , 1982 .