Different effects of 4‐aminopyridine on sensory and motor fibers

Mammalian motor and sensory fibers respond differently to the potassium channel-blocking agent, 4-aminopyridine (4-AP). The action potentials of the motor fibers increase in duration after 4-AP, while the sensory fibers respond with bursts of action potentials after a single stimulus. These differences may account for the paresthesias reported by patients with multiple sclerosis following treatment with 4-AP.

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