论文信息 - Structures of enzymatically modified products of arbekacin by methicillin-resistant. Staphylococcus aureus.

Structures of enzymatically modified products of arbekacin by methicillin-resistant. Staphylococcus aureus.

Only a limited number of strains of methicillin-resistant Staphylococcus aureus (MRSA) moderately resistant to arbekacin (ABK) have been isolated clinically. Three inactivated products of ABK have been obtained by reaction with excess amounts of a crude enzyme preparation extracted from an ABK-resistant MRSA strain (MIC, 25 micrograms/ml). The 2"-O-phosphate was the major product together with small amounts of the 6'-N-acetate and the double modification product. The structures of these modification products were determined by MS and NMR spectral analyses.

[1] T. Takeuchi,et al. [Susceptibility of methicillin-resistant Staphylococcus aureus to various antibiotics. Classification by aminoglycoside-modifying enzymes and antibiotics active against MRSA]. , 1991, The Japanese Journal of Antibiotics.

[2] K. Ubukata,et al. Purification and characterization of aminoglycoside-modifying enzymes from Staphylococcus aureus and Staphylococcus epidermidis , 1984, Antimicrobial Agents and Chemotherapy.

[3] M. Másson,et al. Kinetic studies of aminoglycoside acetyltransferase and phosphotransferase from Staphylococcus aureus RPAL. Relationship between the two activities. , 1983, European journal of biochemistry.

[4] H. Umezawa,et al. Mechanisms of Resistance to Aminoglycoside Antibiotics , 1982 .

[5] F. Goffic. The resistance of S.aureus to aminoglycoside antibiotics and pristinamycins in France in 1976〜1977 , 1977 .

[6] J. Duval,et al. New Plasmid-Mediated Nucleotidylation of Aminoglycoside Antibiotics in Staphylococcus aureus , 1976, Antimicrobial Agents and Chemotherapy.

[7] H. Umezawa,et al. [12] Electrophoresis of antibiotics , 1975 .

[8] S. Kondo,et al. Electrophoresis of antibiotics. , 1975, Methods in enzymology.

[9] H. Umezawa,et al. Letter: Syntheses of 1-n-(S)-4-amino-2-hydroxybutyryl)-kanamycin B and -3', 4'-dideoxykanamycin B active against kanamycin-resistant bacteria. , 1973, The Journal of antibiotics.