Sulfhydryl Groups in Resting and Stimulated Rat Brain; Their Relationship with Protein Structure

Summary An increase in titratable -SH groups was observed in rat brain stimulated through its afferent nerves. The change is reversible when the resting state is restored, The increase produced by stimulation affects mainly the non-dialyzable, presumably protein-bound -SH groups. The change is interpreted as an indication of structural rearrangement of certain proteins which may participate in the mechanism of excitation.