Pharmacological characterization of the seven human NOX isoforms and their inhibitors
暂无分享,去创建一个
K. Krause | J. Doroshow | R. Stocker | P. Jansen-Dürr | U. Knaus | Fiona Augsburger | V. Jaquet | G. Maghzal | T. Seredenina | A. Filippova | M. Lam | Zahia Mahiout | Delphine Rasti
[1] W. Nauseef,et al. Isolation of Human Neutrophils from Venous Blood. , 2019, Methods in molecular biology.
[2] Xuan Wang,et al. The novel NADPH oxidase 4 selective inhibitor GLX7013114 counteracts human islet cell death in vitro , 2018, PloS one.
[3] Y. Berdichevsky,et al. Binding of p67phox to Nox2 is stabilized by disulfide bonds between cysteines in the 369Cys‐Gly‐Cys371 triad in Nox2 and in p67phox , 2018, Journal of leukocyte biology.
[4] R. Grimley,et al. Mechanistic enzymology in drug discovery: a fresh perspective , 2017, Nature Reviews Drug Discovery.
[5] S. Meuth,et al. NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage , 2017, Proceedings of the National Academy of Sciences.
[6] E. Lobarinas,et al. Safety and efficacy of ebselen for the prevention of noise-induced hearing loss: a randomised, double-blind, placebo-controlled, phase 2 trial , 2017, The Lancet.
[7] S. Carnésecchi,et al. Therapeutic potential of NADPH oxidase 1/4 inhibitors , 2017, British journal of pharmacology.
[8] A. Shah,et al. Decoding NADPH oxidase 4 expression in human tumors , 2017, Redox biology.
[9] Haiching Ma,et al. Developing selective histone deacetylases (HDACs) inhibitors through ebselen and analogs , 2017, Drug design, development and therapy.
[10] Edward Ryder,et al. Genome-wide in vivo screen identifies novel host regulators of metastatic colonization , 2017, Nature.
[11] S. Taddei,et al. Impact of apocynin on vascular disease in hypertension. , 2016, Vascular pharmacology.
[12] A. Goldfine,et al. Ebselen does not improve oxidative stress and vascular function in patients with diabetes: a randomized, crossover trial. , 2016, American journal of physiology. Heart and circulatory physiology.
[13] A. Aguzzi,et al. Evaluation of NADPH oxidases as drug targets in a mouse model of familial amyotrophic lateral sclerosis. , 2016, Free radical biology & medicine.
[14] H. Schmidt,et al. NOX4-derived reactive oxygen species limit fibrosis and inhibit proliferation of vascular smooth muscle cells in diabetic atherosclerosis. , 2016, Free radical biology & medicine.
[15] P. Tsvetkov,et al. Oxidation of Са2+-Binding Domain of NADPH Oxidase 5 (NOX5): Toward Understanding the Mechanism of Inactivation of NOX5 by ROS , 2016, PloS one.
[16] D. Laskin,et al. Selective Targeting of Heme Protein in Cytochrome P450 and Nitric Oxide Synthase by Diphenyleneiodonium. , 2016, Toxicological sciences : an official journal of the Society of Toxicology.
[17] Sun Choi,et al. A novel pyrazole derivative protects from ovariectomy-induced osteoporosis through the inhibition of NADPH oxidase , 2016, Scientific Reports.
[18] K. Krause,et al. A subset of N-substituted phenothiazines inhibits NADPH oxidases. , 2015, Free radical biology & medicine.
[19] C. Davies,et al. Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor. , 2015, Antioxidants & redox signaling.
[20] H. Schmidt,et al. Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement. , 2015, Antioxidants & redox signaling.
[21] D. Faigel,et al. Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic and renal cancer cell lines , 2015, Oncotarget.
[22] R. Bhatta,et al. Pharmacokinetic, bioavailability, metabolism and plasma protein binding evaluation of NADPH-oxidase inhibitor apocynin using LC-MS/MS. , 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
[23] Decheng Bai,et al. A coumarin-based two-photon probe for hydrogen peroxide. , 2015, Biosensors & bioelectronics.
[24] N. Saito,et al. The Extracellular A-loop of Dual Oxidases Affects the Specificity of Reactive Oxygen Species Release* , 2015, The Journal of Biological Chemistry.
[25] L. Scapozza,et al. Diapocynin, a Dimer of the NADPH Oxidase Inhibitor Apocynin, Reduces ROS Production and Prevents Force Loss in Eccentrically Contracting Dystrophic Muscle , 2014, PloS one.
[26] J. Lambeth,et al. Nox4: A Hydrogen Peroxide-Generating Oxygen Sensor , 2014, Biochemistry.
[27] J. Lambeth,et al. High-throughput Assays for Superoxide and Hydrogen Peroxide , 2014, The Journal of Biological Chemistry.
[28] H. Sumimoto,et al. N-Linked glycosylation of the superoxide-producing NADPH oxidase Nox1. , 2014, Biochemical and biophysical research communications.
[29] R. Payne,et al. Assessment of Myeloperoxidase Activity by the Conversion of Hydroethidine to 2-Chloroethidium* , 2014, The Journal of Biological Chemistry.
[30] J. Lambeth,et al. On the use of L-012, a luminol-based chemiluminescent probe, for detecting superoxide and identifying inhibitors of NADPH oxidase: a reevaluation. , 2013, Free radical biology & medicine.
[31] Han Liu,et al. Characterization of NADPH oxidase 5 expression in human tumors and tumor cell lines with a novel mouse monoclonal antibody. , 2013, Free radical biology & medicine.
[32] A. Shah,et al. A 28-kDa Splice Variant of NADPH Oxidase-4 Is Nuclear-Localized and Involved in Redox Signaling in Vascular Cells , 2013, Arteriosclerosis, thrombosis, and vascular biology.
[33] P. Ortiz de Montellano,et al. Conserved Cysteine Residues Provide a Protein-Protein Interaction Surface in Dual Oxidase (DUOX) Proteins* , 2013, The Journal of Biological Chemistry.
[34] Z. Ao,et al. NADPH oxidase-dependent and -independent mechanisms of reported inhibitors of reactive oxygen generation , 2013, Journal of enzyme inhibition and medicinal chemistry.
[35] J. Joseph,et al. Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson’s disease , 2012, Journal of Neuroinflammation.
[36] J. Snyder,et al. Ebselen and congeners inhibit NADPH oxidase 2-dependent superoxide generation by interrupting the binding of regulatory subunits. , 2012, Chemistry & biology.
[37] J. Stamler,et al. Off-target thiol alkylation by the NADPH oxidase inhibitor 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine (VAS2870). , 2012, Free radical biology & medicine.
[38] M. Sokolowska,et al. Apocynin reduces reactive oxygen species concentrations in exhaled breath condensate in asthmatics , 2012, Experimental lung research.
[39] K. Krause,et al. NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action , 2011, British journal of pharmacology.
[40] E. Rajnavölgyi,et al. Molecular and Functional Characterization of Hv1 Proton Channel in Human Granulocytes , 2010, PloS one.
[41] Sophie Houngninou-Molango,et al. First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis. , 2010, Journal of medicinal chemistry.
[42] K. Krause,et al. Small-molecule NOX inhibitors: ROS-generating NADPH oxidases as therapeutic targets. , 2009, Antioxidants & redox signaling.
[43] B. Torbett,et al. Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells , 2009, Journal of Cell Science.
[44] S. Belinsky,et al. Silencing of DUOX NADPH oxidases by promoter hypermethylation in lung cancer. , 2008, Cancer research.
[45] K. Krause,et al. NOX5 is expressed at the plasma membrane and generates superoxide in response to protein kinase C activation. , 2007, Biochimie.
[46] M. S. Galhiane,et al. The oxidation of apocynin catalyzed by myeloperoxidase: proposal for NADPH oxidase inhibition. , 2007, Archives of biochemistry and biophysics.
[47] S. Rosenkranz,et al. Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation. , 2006, Cardiovascular research.
[48] H. Kikuchi,et al. The NADPH Oxidase Nox3 Constitutively Produces Superoxide in a p22phox-dependent Manner , 2005, Journal of Biological Chemistry.
[49] Karl-Heinz Krause,et al. NOX3, a Superoxide-generating NADPH Oxidase of the Inner Ear* , 2004, Journal of Biological Chemistry.
[50] H. van Dijk,et al. Effects of methoxylation of apocynin and analogs on the inhibition of reactive oxygen species production by stimulated human neutrophils. , 2001, European journal of pharmacology.
[51] J. Stolk,et al. Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol. , 1994, American journal of respiratory cell and molecular biology.
[52] Y. Yamamoto,et al. Action of ebselen as an antioxidant against lipid peroxidation. , 1992, Biochemical pharmacology.
[53] C. Nathan,et al. Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs 1 , 1991, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[54] A. Verhoeven,et al. Characterization of two monoclonal antibodies against cytochrome b558 of human neutrophils. , 1989, Blood.
[55] A. Cross,et al. The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils. Specific labelling of a component polypeptide of the oxidase. , 1986, The Biochemical journal.
[56] P. Holland,et al. Biochemical effects of hypoglycaemic compound diphenyleneiodonium in rat liver mitochondria: inhibition of adenosine triphosphate synthesis. , 1971, Biochemical Journal.
[57] K. Krause,et al. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. , 2007, Physiological reviews.
[58] W. Nauseef. Isolation of human neutrophils from venous blood. , 2007, Methods in molecular biology.
[59] F. D. Moore. First class. , 1980, The New England journal of medicine.
[60] S. Gatley,et al. Some aspects of the pharmacology of diphenyleneiodonium, a bivalent iodine compound. , 1979, Xenobiotica; the fate of foreign compounds in biological systems.