OBesogenic Endocrine disrupting chemicals: LInking prenatal eXposure to the development of obesity later in life

Executive Summary: OBELIX (OBesogenic Endocrine disrupting chemicals (EDCs): LInking prenatal eXposure to the development of obesity later in life) is a multidisciplinary European research project that was performed from May 2009 to November 2013. The main goal of OBELIX was to investigate if early life exposure to EDCs plays a role in the development of obesity and related disorders later in life. OBELIX investigated six major classes of EDCs, including dioxins, polychlorinated biphenyls, brominated ame retardants, organochlorine pesticides, phthalates, and per uorinated alkyl acids (PFAAs). The main objectives and main conclusions of OBELIX were: 1. To assess early life (perinatal) exposure in humans to major classes of EDs in food, using mother-child cohorts from various European regions. OBELIX demonstrated that perinatal exposure to major classes of EDCs is widespread across Europe. New methods were developed for the sensitive analysis of phthalate metabolites and PFAAs in cord blood and breast milk. Novel postnatal exposure models to EDCs were developed, indicating divergent effects of preand postnatal exposure to EDCs.

[1]  H. Spekreijse,et al.  Neurodevelopmental retardation, as assessed clinically and with magnetoencephalography and electroencephalography, associated with perinatal dioxin exposure. , 2014, The Science of the total environment.

[2]  M. Lamoree,et al.  Programming of metabolic effects in C57BL/6JxFVB mice by exposure to bisphenol A during gestation and lactation. , 2014, Toxicology.

[3]  M. Casas,et al.  Prenatal Exposure to DDE and PCB 153 and Respiratory Health in Early Childhood: A Meta-Analysis , 2014, Epidemiology.

[4]  M. Kogevinas,et al.  Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children , 2014, The Journal of allergy and clinical immunology.

[5]  M. Casas,et al.  Prenatal PCB-153 Exposure and Decreased Birth Weight: The Role of Gestational Weight Gain , 2014, Environmental health perspectives.

[6]  S. Mandrup,et al.  Transcriptional and Epigenetic Mechanisms Underlying Enhanced in Vitro Adipocyte Differentiation by the Brominated Flame Retardant BDE-47 , 2014, Environmental science & technology.

[7]  T. Hamers,et al.  Effects of endocrine disrupting chemicals on in vitro global DNA methylation and adipocyte differentiation. , 2013, Toxicology in vitro : an international journal published in association with BIBRA.

[8]  J. Legler.  An Integrated Approach to Assess the Role of Chemical Exposure in Obesity , 2013, Obesity.

[9]  I. Hertz-Picciotto,et al.  Anthropometric, socioeconomic, and maternal health determinants of placental transfer of organochlorine compounds , 2013, Environmental Science and Pollution Research.

[10]  E. Hoffman,et al.  Status of LEPR Gene in PCB-exposed Population: A Quick Look , 2013, International journal of human genetics.

[11]  P. De Boever,et al.  Cultured human peripheral blood mononuclear cells alter their gene expression when challenged with endocrine-disrupting chemicals. , 2013, Toxicology.

[12]  Anna Bergström,et al.  Joint Data Analyses Of European Birth Cohorts: Two Different Approaches , 2012 .

[13]  Tomas Trnovec,et al.  Toxicokinetic Modeling of Persistent Organic Pollutant Levels in Blood from Birth to 45 Months of Age in Longitudinal Birth Cohort Studies , 2012, Environmental health perspectives.

[14]  M. de Cock,et al.  Does perinatal exposure to endocrine disruptors induce autism spectrum and attention deficit hyperactivity disorders? Review , 2012, Acta paediatrica.

[15]  A. Bartoňová,et al.  Thyroid hormone metabolism and environmental chemical exposure , 2012, Environmental Health.

[16]  I. Hertz-Picciotto,et al.  Assessment of exposure to PCB 153 from breast feeding and normal food intake in individual children using a system approach model. , 2011, Chemosphere.

[17]  M. Feinberg,et al.  The OBELIX project: early life exposure to endocrine disruptors and obesity. , 2011, The American journal of clinical nutrition.

[18]  R. Slama,et al.  Birth Weight and Prenatal Exposure to Polychlorinated Biphenyls (PCBs) and Dichlorodiphenyldichloroethylene (DDE): A Meta-analysis within 12 European Birth Cohorts , 2011, Environmental health perspectives.

[19]  M. Longnecker,et al.  Associations between brominated flame retardants in human milk and thyroid-stimulating hormone (TSH) in neonates. , 2011, Environmental research.

[20]  M. de Cock,et al.  Obesogenic effects of endocrine disruptors, what do we know from animal and human studies? , 2014, Environment international.

[21]  L. Palkovičová,et al.  Half-lives of serum PCB congener concentrations in environmentally exposed early adolescents. , 2011, Chemosphere.

[22]  Merete Eggesbø,et al.  Determinants of brominated flame retardants in breast milk from a large scale Norwegian study. , 2010, Environment international.