INDUSTRIAL SCALE-UP OF COUNTERCURRENT CHROMATOGRAPHY

The hydrodynamic, engineering, and chromatographic variables affecting scale-up of countercurrent chromatography (CCC) are examined. The predictable and linear scale-up from the current laboratory scale technology to industrial process scale, capable of kgm/month in the first phase, is demonstrated. Continued research will prepare the way for a new generation of tonne/annum capacity high throughput, high resolution CCC machines for pilot and plant scale separations of a range of bioprocess products.

[1]  I. Sutherland,et al.  Industrial scale-up of countercurrent chromatography: predictive scale-up. , 2001, Journal of chromatographic science.

[2]  I. Sutherland,et al.  A NEW HYPOTHESIS ON PHASE DISTRIBUTION IN COUNTERCURRENT CHROMATOGRAPHY , 2000 .

[3]  I. Sutherland.  Relationship between retention, linear velocity and flow for counter-current chromatography. , 2000, Journal of chromatography. A.

[4]  Du,et al.  Low-speed rotary countercurrent chromatography using a convoluted multilayer helical tube for industrial separation , 2000, Analytical chemistry.

[5]  Q. Du,et al.  Relationship between the flow-rate of the mobile phase and retention of the stationary phase in counter-current chromatography , 1999 .

[6]  J. Goupy,et al.  EXPERIMENTAL DESIGNS APPLIED TO COUNTERCURRENT CHROMATOGRAPHY : DEFINITIONS, CONCEPTS, AND APPLICATIONS , 1999 .

[7]  I. Sutherland,et al.  Countercurrent Chromatography (CCC) and its Versatile Application as an Industrial Purification & Production Process , 1998 .

[8]  Y. Ito.  pH-Peak-Focusing and pH-Zone-Refining Countercurrent Chromatography , 1996 .

[9]  K. Hostettmann,et al.  Counter-current chromatography as a preparative tool —applications and perspectives , 1994 .

[10]  A. Berthod.  Practical approach to high-speed counter-current chromatography , 1991 .

[11]  Y. Ito,et al.  Large-Scale Preparative Counter-Current Chromatography with a Coil Planet Centrifuge , 1985 .

[12]  Y. Ito,et al.  Gram Quantity Separation of DNP (Dinitrophenyl) Amino Acids with Multi-Layer Coil Countercurrent Chromatography (CCC) , 1984 .

[13]  Y. Ito,et al.  Preparative counter-current chromatography with a rotating coil assembly , 1981 .