Intracranial Pressure Telemetry System Using Semicustom Integrated Circuits

A new generation of implantable, telemetric transmitters for intracranial pressure (ICP) measurements have been developed. A unique technique used in packaging the silicon piezoresistive pt essure transducer provides excellent long-term stability. Pulse code modulation is used for data transmission over a radio frequency (RF) link. To minimize the component count, two semicustom, bipolar integrated circuits are used. The transmitter electronics are housed inside a 29 ×20 ×7 mm titanium package along with the pressure transducer and two lithium batteries. Even though the transmitter consumes less than 0.4 mW of power, it is turned on remotely via RF signal transduction only on demand in order to extend the lifetime of the batteries to years. The pressure input of the transmitter has a dynamic range of ¿100- +200 mmHg with a 0.3 mmHg resolution and a 1 mmHg accuracy. Long-term in vitro and in vivo pressure baseline stabilities of better than 1 and 2 mmHg per month, respectively, have been achieved.

[1]  The glass sealing properties of titanium and zirconium , 1954 .

[2]  J R Atkinson,et al.  Radio telemetry for the measurement of intracranial pressure. , 1967, Journal of neurosurgery.

[3]  C C Collins,et al.  Intracranial pressure measurement with a miniature passive implanted pressure transensor. , 1967, American journal of surgery.

[4]  G. Wallis,et al.  Field Assisted Glass‐Metal Sealing , 1969 .

[5]  M. Brock,et al.  A Modified Equipment for the Continuous Telemetric Monitoring of Epidural or Subdural Pressure , 1972 .

[6]  Integral glass sheet encapsulation for terrestrial panel applications. [solar cell modules , 1976 .

[7]  H. G. Rylander,et al.  Chronic measurement of epidural pressure with an induction-powered oscillator transducer. , 1976, Journal of neurosurgery.

[8]  E. Cosman,et al.  A pressure-balanced radio-telemetry system for the measurement of intracranial pressure. A preliminary design report. , 1977, Journal of neurosurgery.

[9]  T B Fryer,et al.  Telemetry of intracranial pressure. , 1978, Biotelemetry and patient monitoring.

[10]  K. Wise,et al.  Pressure sensitivity in anisotropically etched thin-diaphragm pressure sensors , 1979, IEEE Transactions on Electron Devices.

[11]  W. Ko,et al.  Development of a miniature pressure transducer for biomedical applications , 1979, IEEE Transactions on Electron Devices.

[12]  L. Marshall,et al.  The outcome with aggressive treatment in severe head injuries. Part I: the significance of intracranial pressure monitoring. , 1979, Journal of neurosurgery.

[13]  L. Marshall,et al.  The outcome with aggressive treatment in severe head injuries. Part II: acute and chronic barbiturate administration in the management of head injury. , 1979, Journal of neurosurgery.

[14]  P. Younger Hermetic glass sealing by electrostatic bonding , 1980 .

[15]  Intracranial pressure telemetry system. II. Animal testing. , 1981, Biotelemetry and patient monitoring.

[16]  W H Ko,et al.  An implantable micropower command receiver for telemetry battery power switching. , 1981, Biotelemetry and patient monitoring.

[17]  Kensall D. Wise Integrated sensors: interfacing electronics to a non-electronic world , 1981 .

[18]  Xian-Ping Wu,et al.  An integrated pressure transducer for biomedical applications , 1981 .

[19]  W H Ko,et al.  Intracranial pressure telemetry system. I. Hardware development. , 1981, Biotelemetry and patient monitoring.

[20]  M. Esashi,et al.  Fabrication of catheter-tip and sidewall miniature pressure sensors , 1982, IEEE Transactions on Electron Devices.

[21]  K. Wise,et al.  A batch-fabricated silicon capacitive pressure transducer with low temperature sensitivity , 1982, IEEE Transactions on Electron Devices.

[22]  Wen H. Ko,et al.  Packaging Materials and Techniques for Implantable Instruments , 1983, Engineering in Medicine and Biology Magazine.