Frontal Lobe Function and Dysfunction

Introduction and historical perspective Neuroanatomical organization, experimental models and neuroimaging in animals Cognitive functioning in patients with frontal lobe lesions The role of the frontal lobes in memory Response preparation and motor functioning Integration of experimental models with studies of patients Neuropsychiatric and developmental effects of frontal lobe damage Rehabilitation of the frontal lobe damaged patient Summary.

[1]  C. Jacobsen,et al.  Studies of cerebral function in primates. I. The functions of the frontal association areas in monkeys. , 1936 .

[2]  G. Bonin,et al.  The neocortex of Macaca mulatta , 1947 .

[3]  C. Woolsey,et al.  The orbitofrontal cortex and its connections with the mediodorsal nucleus in rabbit, sheep and cat. , 1948, Research publications - Association for Research in Nervous and Mental Disease.

[4]  H. Harlow.  Analysis of discrimination learning by monkeys. , 1950 .

[5]  H. Harlow,et al.  Analysis of frontal and posterior association syndromes in brain-damaged monkeys. , 1952, Journal of comparative and physiological psychology.

[6]  J. Wilder.  The Origins of Intelligence in Children , 1954 .

[7]  M. Mishkin,et al.  Effects of object preferences and aversions on discrimination learning in monkeys with frontal lesions. , 1961 .

[8]  H E ROSVOLD,et al.  One-trial objectdiscrimination learning in monkeys with frontal lesions. , 1962, Journal of comparative and physiological psychology.

[9]  M. Cole.  The Frontal Granular Cortex and Behavior. , 1964 .

[10]  R. L. Fantz.  Visual Experience in Infants: Decreased Attention to Familiar Patterns Relative to Novel Ones , 1964, Science.

[11]  R. Douglas,et al.  The hippocampus and behavior. , 1967, Psychological bulletin.

[12]  M. Mishkin,et al.  Projections from behaviorally-defined sectors of the prefrontal cortex to the basal ganglia, septum, and diencephalon of the monkey. , 1968, Experimental neurology.

[13]  D. Pandya,et al.  Cortico-cortical connections in the rhesus monkey. , 1969, Brain research.

[14]  Mortimer Mishkin,et al.  A re-examination of the effects of frontal lesions on object alternation , 1969 .

[15]  D. Pandya,et al.  Interhemispheric projections of the parietal lobe in the rhesus monkey. , 1969, Brain research.

[16]  J. Fagan.  Memory in the infant. , 1970, Journal of experimental child psychology.

[17]  H. E. Rosvold,et al.  Localization of function within the dorsolateral prefrontal cortex of the rhesus monkey. , 1970, Experimental neurology.

[18]  F. Hudson,et al.  Evaluation of Treatment Begun in First Three Months of Life in 184 Cases of Phenylketonuria , 1970, Archives of disease in childhood.

[19]  W. Nauta.  The problem of the frontal lobe: a reinterpretation. , 1971, Journal of psychiatric research.

[20]  B. Milner,et al.  Interhemispheric differences in the localization of psychological processes in man. , 1971, British medical bulletin.

[21]  T. Powell,et al.  The connexions of the striatum and globus pallidus: synthesis and speculation. , 1971, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[22]  D. Pandya,et al.  Intra- and interhemispheric projections of the precentral, premotor and arcuate areas in the rhesus monkey. , 1971, Brain research.

[23]  W. F. Landers,et al.  Stage IV of Piaget's theory of infant's object concepts: a longitudinal study. , 1971, Child development.

[24]  G. E. Alexander,et al.  Neuron Activity Related to Short-Term Memory , 1971, Science.

[25]  P. S. Goldman.  Functional development of the prefrontal cortex in early life and the problem of neuronal plasticity. , 1971, Experimental neurology.

[26]  H. E. Rosvold,et al.  The effects of selective caudate lesions in infant and juvenile Rhesus monkeys. , 1972, Brain research.

[27]  H. E. Rosvold,et al.  The frontal lobe system: cortical-subcortical interrelationships. , 1972, Acta neurobiologiae experimentalis.

[28]  W. S. Millar,et al.  The influence of spatially displaced feedback on infant operant conditioning. , 1972, Journal of experimental child psychology.

[29]  P L Harris,et al.  Perseverative errors in search by young infants. , 1973, Child development.

[30]  Functional recovery after lesions of the nervous systems. 3. Developmental processes in neural plasticity. Recovery of function after CNS lesions in infant monkeys. , 1974 .

[31]  G. Gratch,et al.  Piaget's stage IV object concept error: evidence of forgetting or object conception? , 1974, Child development.

[32]  E. Perret.  The left frontal lobe of man and the suppression of habitual responses in verbal categorical behaviour. , 1974, Neuropsychologia.

[33]  H. Niki.  Differential activity of prefrontal units during right and left delayed response trials. , 1974, Brain research.

[34]  D. Gaffan,et al.  Recognition impaired and association intact in the memory of monkeys after transection of the fornix. , 1974, Journal of comparative and physiological psychology.

[35]  G. Butterworth.  Object Identity in Infancy: The Interaction of Spatial Location Codes in Determining Search Errors. , 1975 .

[36]  M Mishkin,et al.  An analysis of short-term visual memory in the monkey. , 1975, Journal of experimental psychology. Animal behavior processes.

[37]  H. Kuypers,et al.  Intrahemispheric cortical connexions and visual guidance of hand and finger movements in the rhusus monkey. , 1975, Brain : a journal of neurology.

[38]  G. Gratch.  Recent Studies Based on Piaget's View of Object Concept Development , 1975 .

[39]  Walle J. H. Nauta,et al.  Autoradiographic demonstration of a projection from prefrontal association cortex to the superior colliculus in the rhesus monkey , 1976, Brain Research.

[40]  Maureen Dennis,et al.  Impaired sensory and motor differentiation with corpus callosum agenesis: A lack of callosal inhibition during ontogeny? , 1976, Neuropsychologia.

[41]  Comparative analysis of prefrontal learning functions in rats, cats, and monkeys. , 1977, Psychological bulletin.

[42]  W. Nauta,et al.  An intricately patterned prefronto‐caudate projection in the rhesus monkey , 1977, The Journal of comparative neurology.

[43]  J. Talairach,et al.  Clinical consequences of corticectomies involving the supplementary motor area in man , 1977, Journal of the Neurological Sciences.

[44]  R. Koch,et al.  Intellectual assessment of 111 four-year-old children with phenylketonuria. , 1977, Pediatrics.

[45]  J. G. Bremner,et al.  Place versus response as the basis of spatial errors made by young infants. , 1977, Journal of experimental child psychology.

[46]  H. Kuypers,et al.  Premotor cortical ablations in monkeys: contralateral changes in visually guided reaching behavior. , 1977, Science.

[47]  H. Künzle.  An autoradiographic analysis of the efferent connections from premotor and adjacent prefrontal regions (areas 6 and 9) in macaca fascicularis. , 1978, Brain, behavior and evolution.

[48]  M. Mishkin.  Memory in monkeys severely impaired by combined but not by separate removal of amygdala and hippocampus , 1978, Nature.

[49]  Margaret C. Donaldson.  Children's Minds , 1978 .

[50]  R. Passingham,et al.  Converging projections from the mediodorsal thalamic nucleus and mesencephalic dopaminergic neurons to the neocortex in three species , 1978, The Journal of comparative neurology.

[51]  R. LaMotte,et al.  Defects in accuracy of reaching after removal of posterior parietal cortex in monkeys , 1978, Brain Research.

[52]  J. Werner,et al.  Development of visual memory in infants. , 1979, Advances in child development and behavior.

[53]  H. E. Rosvold,et al.  Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey. , 1979, Science.

[54]  J. Kagan,et al.  The growth of memory during infancy. , 1979, Genetic psychology monographs.

[55]  A. Crane,et al.  Regional distribution of monoamines in the cerebral cortex and subcortical structures of the rhesus monkey: concentrations and in vivo synthesis rates , 1979, Brain Research.

[56]  D. C. Essen,et al.  Visual areas of the mammalian cerebral cortex. , 1979 .

[57]  A. Luria.  Higher Cortical Functions in Man , 1980, Springer US.

[58]  P. Rakić,et al.  The time of origin of neurons in the hippocampal region of the rhesus monkey , 1981, The Journal of comparative neurology.

[59]  M. Grossman.  Reversal operations after brain damage , 1982, Brain and Cognition.

[60]  P. Goldman-Rakic,et al.  Interdigitation of contralateral and ipsilateral columnar projections to frontal association cortex in primates. , 1982, Science.

[61]  B. Milner,et al.  Deficits on subject-ordered tasks after frontal- and temporal-lobe lesions in man , 1982, Neuropsychologia.

[62]  J. Corwin,et al.  Behavioral effects of lesions to the caudate nucleus or mediodorsal thalamus in neonatal, juvenile, and adult rats , 1982 .

[63]  P S Goldman-Rakic,et al.  Postnatal development of monoamine content and synthesis in the cerebral cortex of rhesus monkeys. , 1982, Brain research.

[64]  P. Goldman-Rakic,et al.  Brainstem innervation of prefrontal and anterior cingulate cortex in the rhesus monkey revealed by retrograde transport of HRP , 1982, The Journal of comparative neurology.

[65]  D. Jacobowitz,et al.  A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[66]  R. Mayeux,et al.  Perceptual motor dysfunction in Parkinson's disease: a deficit in sequential and predictive voluntary movement. , 1983, Journal of neurology, neurosurgery, and psychiatry.

[67]  D. Primrose.  Phenylketonuria with normal intelligence. , 2008, Journal of mental deficiency research.

[68]  A. Lees,et al.  Cognitive deficits in the early stages of Parkinson's disease. , 1983, Brain : a journal of neurology.

[69]  Larry R. Squire,et al.  CHAPTER 6 – THE NEUROLOGY OF MEMORY: THE CASE FOR CORRESPONDENCE BETWEEN THE FINDINGS FOR HUMAN AND NONHUMAN PRIMATE1 , 1983 .

[70]  D. Gaffan,et al.  Effects of Fornix Transection on Spontaneous and Trained Non-Matching by Monkeys , 1984, The Quarterly journal of experimental psychology. B, Comparative and physiological psychology.

[71]  C. Brinkman.  Supplementary motor area of the monkey's cerebral cortex: short- and long-term deficits after unilateral ablation and the effects of subsequent callosal section , 1984, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[72]  A. Nonneman,et al.  Role of the caudate nucleus in recovery from neonatal mediofrontal cortex lesions in the rat. , 1984, Developmental psychobiology.

[73]  P S Goldman-Rakic,et al.  Callosal and intrahemispheric connectivity of the prefrontal association cortex in rhesus monkey: Relation between intraparietal and principal sulcal cortex , 1984, The Journal of comparative neurology.

[74]  G. Hynd,et al.  Neuropsychological development of behavior attributed to frontal lobe functioning in children , 1985 .

[75]  D. Freides,et al.  Biochemical and neuropsychological effects of elevated plasma phenylalanine in patients with treated phenylketonuria. A model for the study of phenylalanine and brain function in man. , 1985, The Journal of clinical investigation.

[76]  R. Passingham.  Premotor cortex: Sensory cues and movement , 1985, Behavioural Brain Research.

[77]  B. Milner,et al.  Frontal lobes and the temporal organization of memory. , 1985, Human neurobiology.

[78]  A. Diamond,et al.  Development of the ability to use recall to guide action, as indicated by infants' performance on AB. , 1985, Child development.

[79]  P. Goldman-Rakic,et al.  Longitudinal topography and interdigitation of corticostriatal projections in the rhesus monkey , 1985, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[80]  Y. Stern,et al.  Intellectual changes in patients with MPTP‐induced parkinsonism , 1985, Neurology.

[81]  F Wingert,et al.  Growth of the hippocampal formation in man. , 1986, Bibliotheca anatomica.

[82]  Mortimer Mishkin,et al.  Visual recognition impairment follows ventromedial but not dorsolateral prefrontal lesions in monkeys , 1986, Behavioural Brain Research.

[83]  G. Chelune,et al.  Developmental norms for the Wisconsin Card Sorting test. , 1986, Journal of clinical and experimental neuropsychology.

[84]  L. Squire,et al.  Memory impairment in monkeys following lesions limited to the hippocampus. , 1986, Behavioral neuroscience.

[85]  R. Kronmal,et al.  Effect of age at loss of dietary control on intellectual performance and behavior of children with phenylketonuria. , 1986, The New England journal of medicine.

[86]  I. Mitchell,et al.  Neural mechanisms mediating 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in the monkey: Relative contributions of the striatopallidal and striatonigral pathways as suggested by 2-deoxyglucose uptake , 1986, Neuroscience Letters.

[87]  D. Schacter.  Implicit memory: History and current status. , 1987 .

[88]  J. Mazziotta,et al.  Positron emission tomography study of human brain functional development , 1987, Annals of neurology.

[89]  R. Roth,et al.  Differential responsiveness to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in sub-regions of the primate substantia nigra and striatum. , 1987, Life sciences.

[90]  H. Furth.  Object permanence in five-month-old infants. , 1987, Cognition.

[91]  P. Goldman-Rakic,et al.  Common cortical and subcortical targets of the dorsolateral prefrontal and posterior parietal cortices in the rhesus monkey: evidence for a distributed neural network subserving spatially guided behavior , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[92]  L. Squire,et al.  Human amnesia and animal models of amnesia: performance of amnesic patients on tests designed for the monkey. , 1988, Behavioral neuroscience.

[93]  P. Rakić,et al.  Nature and fate of proliferative cells in the hippocampal dentate gyrus during the life span of the rhesus monkey , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[94]  Javier Quintana,et al.  Prefrontal representation of stimulus attributes during delay tasks. I. Unit activity in cross-temporal integration of sensory and sensory-motor information , 1988, Brain Research.

[95]  A. Diamond,et al.  The performance of human infants on a measure of frontal cortex function, the delayed response task. , 1989, Developmental psychobiology.

[96]  P. Goldman-Rakic,et al.  Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex. , 1989, Journal of neurophysiology.

[97]  M. Piccirilli,et al.  Frontal lobe dysfunction in Parkinson's disease: prognostic value for dementia? , 1989, European neurology.

[98]  L. Squire,et al.  Successful performance by monkeys with lesions of the hippocampal formation on AB and object retrieval, two tasks that mark developmental changes in human infants. , 1989, Behavioral neuroscience.

[99]  A. Angelucci,et al.  Segregation and overlap of callosal and association neurons in frontal and parietal cortices of primates: a spectral and coherency analysis , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[100]  J. Fagan.  The Paired‐Comparison Paradigm and Infant Intelligence , 1990, Annals of the New York Academy of Sciences.

[101]  W. Overman.  Performance on Traditional Matching to Sample, Non‐Matching to Sample, and Object Discrimination Tasks by 12‐ to 32‐Month‐Old Children , 1990, Annals of the New York Academy of Sciences.

[102]  J. Saint-Cyr,et al.  Memory and learning in early Parkinson's disease: Evidence for a “frontal lobe syndrome” , 1990, Brain and Cognition.

[103]  A. Diamond,et al.  Rate of Maturation of the Hippocampus and the Developmental Progression of Children's Performance on the Delayed Non‐Matching to Sample and Visual Paired Comparison Tasks a , 1990, Annals of the New York Academy of Sciences.

[104]  B. Pennington,et al.  Neuropsychology of early-treated phenylketonuria: specific executive function deficits. , 1990, Child development.

[105]  Arthur P. Shimamura,et al.  Memory for the temporal order of events in patients with frontal lobe lesions and amnesic patients , 1990, Neuropsychologia.

[106]  Adele Diamond,et al.  Frontal lobe involvement in cognitive changes during the first year of life. , 1991 .

[107]  J. Stroop.  Studies of interference in serial verbal reactions. , 1992 .