Molecular imaging: exploring the next frontier.

[1]  R Weissleder,et al.  Near-infrared optical imaging of protease activity for tumor detection. , 1999, Radiology.

[2]  R. Weissleder,et al.  In vivo imaging of tumors with protease-activated near-infrared fluorescent probes , 1999, Nature Biotechnology.

[3]  R Weissleder,et al.  High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates. , 1999, Bioconjugate chemistry.

[4]  Donald S. Williams,et al.  Detection of single mammalian cells by high-resolution magnetic resonance imaging. , 1999, Biophysical journal.

[5]  J. Kruskal,et al.  Gene therapy: a primer for radiologists. , 1998, Radiographics : a review publication of the Radiological Society of North America, Inc.

[6]  S. Cherry,et al.  Imaging of adenoviral-directed herpes simplex virus type 1 thymidine kinase reporter gene expression in mice with radiolabeled ganciclovir. , 1998, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[7]  M. Kuo,et al.  Vascular gene therapy. , 1998, Radiographics : a review publication of the Radiological Society of North America, Inc.

[8]  J. Humm,et al.  Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography. , 1998, Cancer research.

[9]  R. Xavier,et al.  Tumor Induction of VEGF Promoter Activity in Stromal Cells , 1998, Cell.

[10]  R. Weissleder,et al.  Mapping the in vivo distribution of herpes simplex virions. , 1998, Human gene therapy.

[11]  S S Gambhir,et al.  Evaluating tumor biology and oncological disease with positron-emission tomography. , 1998, Seminars in radiation oncology.

[12]  R. Weissleder,et al.  MR imaging of gene delivery to the central nervous system with an artificial vector. , 1998, Radiology.

[13]  R Weissleder,et al.  Measuring transferrin receptor gene expression by NMR imaging. , 1998, Biochimica et biophysica acta.

[14]  R Weissleder,et al.  Design of metal-binding green fluorescent protein variants. , 1998, Biochimica et biophysica acta.

[15]  R. Jain,et al.  Intracellular magnetic labeling of lymphocytes for in vivo trafficking studies. , 1998, BioTechniques.

[16]  David K. Stevenson,et al.  Bioluminescent indicators in living mammals , 1998, Nature Medicine.

[17]  S. Zolotukhin,et al.  A fluorescence video-endoscopy technique for detection of gene transfer and expression , 1998, Gene Therapy.

[18]  R Weissleder,et al.  The development of in vivo imaging systems to study gene expression. , 1998, Trends in biotechnology.

[19]  M. Marmion,et al.  Novel technetium (III)-Q complexes for functional imaging of multidrug resistance (MDR1) P-glycoprotein. , 1998, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[20]  K. Zinn,et al.  Imaging and tissue biodistribution of 99mTc-labeled adenovirus knob (serotype 5) , 1998, Gene Therapy.

[21]  A. Pardee.  Complete genome expression monitoring: The human race , 1997, Nature Biotechnology.

[22]  W. Thomsen,et al.  Molecular approaches to receptors as targets for drug discovery. , 1997, Journal of receptor and signal transduction research.

[23]  M S Feld,et al.  Fluorescence tomographic imaging in turbid media using early-arriving photons and Laplace transforms. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[24]  D. Curiel,et al.  Localization of iodine-125-mIP-Des-Met14-bombesin (7-13)NH2 in ovarian carcinoma induced to express the gastrin releasing peptide receptor by adenoviral vector-mediated gene transfer. , 1997, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[25]  R Weissleder,et al.  MR imaging and scintigraphy of gene expression through melanin induction. , 1997, Radiology.

[26]  R Weissleder,et al.  Paramagnetic metal scavenging by melanin: MR imaging. , 1997, Radiology.

[27]  S M Larson,et al.  Triumph over mischance: a role for nuclear medicine in gene therapy. , 1997, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[28]  J J Burbaum,et al.  New technologies for high-throughput screening. , 1997, Current opinion in chemical biology.

[29]  Scott E. Fraser,et al.  A SMART MAGNETIC RESONANCE IMAGING AGENT THAT REPORTS ON SPECIFIC ENZYMATIC ACTIVITY , 1997 .

[30]  L. Wei,et al.  Transgenic animals as new approaches in pharmacological studies. , 1997, Annual review of pharmacology and toxicology.

[31]  J. Dobkin,et al.  Modulation of the multidrug resistance P-glycoprotein: detection with technetium-99m-sestamibi in vivo. , 1997, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[32]  P. James,et al.  Of genomes and proteomes. , 1997, Biochemical and biophysical research communications.

[33]  R. Weissleder,et al.  Towards in vivo imaging of gene expression: The engineering of metal binding sites , 1997 .

[34]  Thomas Ried,et al.  Multicolour spectral karyotyping of mouse chromosomes , 1996, Nature Genetics.

[35]  R G Blasberg,et al.  Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy. , 1996, Cancer research.

[36]  Sanjay Tyagi,et al.  Molecular Beacons: Probes that Fluoresce upon Hybridization , 1996, Nature Biotechnology.

[37]  R K Jain,et al.  Delivery of Molecular Medicine to Solid Tumors , 1996, Science.

[38]  G. van Kaick,et al.  Monitoring gene therapy with cytosine deaminase: in vitro studies using tritiated-5-fluorocytosine. , 1996, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[39]  R. Blasberg,et al.  Imaging the expression of transfected genes in vivo. , 1995, Cancer research.

[40]  R. Webb,et al.  In vivo confocal scanning laser microscopy of human skin: melanin provides strong contrast. , 1995, The Journal of investigative dermatology.

[41]  S. Broder,et al.  Molecular foundations of cancer: New targets for intervention , 1995, Nature Medicine.

[42]  A. Koretsky.  Nuclear Magnetic Resonance Detection of the Consequences of Transgene Expression , 1994 .

[43]  R Lecomte,et al.  High-resolution PET imaging and quantitation of pharmaceutical biodistributions in a small animal using avalanche photodiode detectors. , 1994, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[44]  A G Yodh,et al.  Scattering of diffuse photon density waves by spherical inhomogeneities within turbid media: analytic solution and applications. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[45]  G. Johnson,et al.  Magnetic resonance microscopy of mouse embryos. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[46]  R E Jacobs,et al.  Magnetic resonance microscopy of embryonic cell lineages and movements. , 1994, Science.

[47]  T. Tamiya,et al.  Gene transfer into experimental brain tumors mediated by adenovirus, herpes simplex virus, and retrovirus vectors. , 1994, Human gene therapy.

[48]  R. Mulligan,et al.  The basic science of gene therapy. , 1993, Science.

[49]  D A Benaron,et al.  Optical time-of-flight and absorbance imaging of biologic media. , 1993, Science.

[50]  L W Hedlund,et al.  Histology by magnetic resonance microscopy. , 1993, Magnetic resonance quarterly.

[51]  K. Jimbow,et al.  Exploitation of pigment biosynthesis pathway as a selective chemotherapeutic approach for malignant melanoma. , 1993, The Journal of investigative dermatology.

[52]  T J Brady,et al.  MR receptor imaging: ultrasmall iron oxide particles targeted to asialoglycoprotein receptors. , 1990, AJR. American journal of roentgenology.

[53]  S. Ito,et al.  4-S-cysteaminylphenol and its analogues as substrates for tyrosinase and monoamine oxidase. , 1990, Pigment cell research.

[54]  J. Kebabian,et al.  125I-iodinated benzazepines bind to melanin: implications for the noninvasive localization of pigmented melanomas. , 1987, International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology.