Tryptophan 207 is crucial to the unique properties of the human voltage-gated proton channel, hHV1

A conserved tryptophan uniquely present in the voltage-sensing domain of voltage-gated proton channels is surprisingly crucial to four channel-defining properties.

[1]  F. Bezanilla,et al.  Resting state of the human proton channel dimer in a lipid bilayer , 2015, Proceedings of the National Academy of Sciences.

[2]  C. Lim,et al.  Selectivity Mechanism of the Voltage-gated Proton Channel, HV1 , 2015, Scientific Reports.

[3]  J. Gribben,et al.  Enhanced activation of an amino-terminally truncated isoform of the voltage-gated proton channel HVCN1 enriched in malignant B cells , 2014, Proceedings of the National Academy of Sciences.

[4]  C. Villalba-Galea.  Hv1 proton channel opening is preceded by a voltage-independent transition. , 2014, Biophysical journal.

[5]  Y. Okamura,et al.  X-ray crystal structure of voltage-gated proton channel , 2014, Nature Structural &Molecular Biology.

[6]  S. Noskov,et al.  Hydrophobic plug functions as a gate in voltage-gated proton channels , 2013, Proceedings of the National Academy of Sciences.

[7]  R. Pomès,et al.  Peregrination of the selectivity filter delineates the pore of the human voltage-gated proton channel hHV1 , 2013, The Journal of general physiology.

[8]  F. Bezanilla,et al.  Molecular Bases for the Asynchronous Activation of Sodium and Potassium Channels Required for Nerve Impulse Generation , 2013, Neuron.

[9]  Régis Pomès,et al.  Construction and validation of a homology model of the human voltage-gated proton channel hHV1 , 2013, The Journal of general physiology.

[10]  T. DeCoursey.  Voltage-gated proton channels: molecular biology, physiology, and pathophysiology of the H(V) family. , 2013, Physiological reviews.

[11]  Klaus Schulten,et al.  Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain , 2013, Nature Structural &Molecular Biology.

[12]  T. Jickells,et al.  Marine Geochemistry: Chester/Marine Geochemistry , 2012 .

[13]  H. Fischer.  Function of Proton Channels in Lung Epithelia. , 2012, Wiley interdisciplinary reviews. Membrane transport and signaling.

[14]  D. Clapham,et al.  The Voltage–gated Proton Channel, Hv1, Enhances Brain Damage from Ischemic Stroke , 2012, Nature Neuroscience.

[15]  D. Tobias,et al.  Water wires in atomistic models of the Hv1 proton channel. , 2012, Biochimica et biophysica acta.

[16]  Yumin Chen,et al.  NOX5 in Human Spermatozoa , 2012, The Journal of Biological Chemistry.

[17]  Y. Okamura,et al.  The cytoplasmic coiled-coil mediates cooperative gating temperature sensitivity in the voltage-gated H+ channel Hv1 , 2012, Nature Communications.

[18]  B. García-Moreno E.,et al.  Arginine residues at internal positions in a protein are always charged , 2011, Proceedings of the National Academy of Sciences.

[19]  A. Place,et al.  Voltage-gated proton channel in a dinoflagellate , 2011, Proceedings of the National Academy of Sciences.

[20]  T. DeCoursey,et al.  Aspartate112 is the Selectivity Filter of the Human Voltage Gated Proton Channel , 2011, Nature.

[21]  C. Brownlee,et al.  A Voltage-Gated H+ Channel Underlying pH Homeostasis in Calcifying Coccolithophores , 2011, PLoS biology.

[22]  T. DeCoursey,et al.  Oligomerization of the voltage gated proton channel , 2010, Channels.

[23]  D. Clapham,et al.  An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1 , 2010, Nature Structural &Molecular Biology.

[24]  D. Iovannisci,et al.  Function of the HVCN1 proton channel in airway epithelia and a naturally occurring mutation, M91T , 2010, The Journal of general physiology.

[25]  R. Gascoyne,et al.  HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species , 2010, Nature Immunology.

[26]  P. Lishko,et al.  Acid Extrusion from Human Spermatozoa Is Mediated by Flagellar Voltage-Gated Proton Channel , 2010, Cell.

[27]  T. DeCoursey.  Voltage-gated proton channels find their dream job managing the respiratory burst in phagocytes. , 2010, Physiology.

[28]  M. Dyer,et al.  Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis , 2009, Proceedings of the National Academy of Sciences.

[29]  M. Kuno,et al.  Temperature dependence of proton permeation through a voltage-gated proton channel , 2009, The Journal of general physiology.

[30]  E. Ríos,et al.  A pH-stabilizing role of voltage-gated proton channels in IgE-mediated activation of human basophils , 2008, Proceedings of the National Academy of Sciences.

[31]  Y. Okamura,et al.  Multimeric nature of voltage-gated proton channels , 2008, Proceedings of the National Academy of Sciences.

[32]  R. MacKinnon,et al.  Dimeric subunit stoichiometry of the human voltage-dependent proton channel Hv1 , 2008, Proceedings of the National Academy of Sciences.

[33]  E. Isacoff,et al.  The Voltage-Gated Proton Channel Hv1 Has Two Pores, Each Controlled by One Voltage Sensor , 2008, Neuron.

[34]  D. Clapham,et al.  Detailed comparison of expressed and native voltage‐gated proton channel currents , 2008, The Journal of physiology.

[35]  W F Drew Bennett,et al.  Distribution of amino acids in a lipid bilayer from computer simulations. , 2008, Biophysical journal.

[36]  David E. Clapham,et al.  A voltage-gated proton-selective channel lacking the pore domain , 2006, Nature.

[37]  E. Ligeti,et al.  Regulation and termination of NADPH oxidase activity , 2005, Cellular and Molecular Life Sciences CMLS.

[38]  Jinrang Kim,et al.  Are acidic and basic groups in buried proteins predicted to be ionized? , 2005, Journal of molecular biology.

[39]  Conrad C. Huang,et al.  UCSF Chimera—A visualization system for exploratory research and analysis , 2004, J. Comput. Chem..

[40]  C. Tatko,et al.  The geometry and efficacy of cation–π interactions in a diagonal position of a designed β‐hairpin , 2003 .

[41]  Deri Morgan,et al.  The voltage dependence of NADPH oxidase reveals why phagocytes need proton channels , 2003, Nature.

[42]  T. DeCoursey.  Voltage-gated proton channels and other proton transfer pathways. , 2003, Physiological reviews.

[43]  J. Killian,et al.  How proteins adapt to a membrane-water interface. , 2000, Trends in biochemical sciences.

[44]  D. A. Dougherty,et al.  Cation-π interactions in structural biology , 1999 .

[45]  T. DeCoursey,et al.  Temperature Dependence of Voltage-gated H+ Currents in Human Neutrophils, Rat Alveolar Epithelial Cells, and Mammalian Phagocytes , 1998, The Journal of general physiology.

[46]  T. DeCoursey,et al.  Deuterium Isotope Effects on Permeation and Gating of Proton Channels in Rat Alveolar Epithelium , 1997, The Journal of general physiology.

[47]  V. Markin,et al.  The voltage-activated hydrogen ion conductance in rat alveolar epithelial cells is determined by the pH gradient , 1995, The Journal of general physiology.

[48]  Yu Huang,et al.  Electrostatic interactions of S4 voltage sensor in shaker K+ channel , 1995, Neuron.

[49]  O. Jones,et al.  The superoxide-generating NADPH oxidase of human neutrophils is electrogenic and associated with an H+ channel. , 1987, The Biochemical journal.

[50]  G A Petsko,et al.  Amino‐aromatic interactions in proteins , 1986, FEBS letters.

[51]  J. W. Hastings,et al.  Bioluminescence: mechanism and mode of control of scintillon activity. , 1972, Proceedings of the National Academy of Sciences of the United States of America.

[52]  T. DeCoursey,et al.  Analysis of electrophysiological properties and responses of neutrophils. , 2014, Methods in molecular biology.

[53]  R. Pomès,et al.  Construction and validation of a homology model of the human voltage-gated proton channel hHV 1 , 2013 .

[54]  Xing-ye Wu,et al.  Clinicopathological and Biological Significance of Human Voltage-gated Proton Channel Hv1 Protein Overexpression in Breast Cancer* , 2012, The Journal of Biological Chemistry.

[55]  D. Iovannisci,et al.  Function of the HVCN 1 proton channel in airway epithelia and a naturally occurring mutation , M 91 T , 2010 .

[56]  M. Jiménez,et al.  Tryptophan residues: Scarce in proteins but strong stabilizers of β‐hairpin peptides , 2010, Biopolymers.

[57]  W. Boron,et al.  Intracellular pH. , 1981, Physiological reviews.

[58]  J. D. Burton,et al.  Marine Geochemistry , 1973, Nature.