Timing and magnitude of frontal activity differentiates refixation and anti-saccade performance

EEG data were recorded while 10 subjects generated refixation saccades towards a visual target and antisaccades away from a visual cue. Theoretically, the same basic neural circuitry supports refixation and correct anti-saccade performances, with additional activity in primarily dorsolateral prefrontal cortex circuitry supporting antisaccade-associated inhibitory processes. Analyses demonstrated that sensory registration of visual stimuli is similar for refixation and anti-saccade conditions. Increased frontal brain activity at 5 and 15 Hz was observed preceding correct antisaccades when compared to refixation saccades. These analyses provide specific information suggesting that 160–60 ms before saccade generation is the critical period for response inhibition.

[1]  Christoph Klein,et al.  Impaired modulation of the saccadic contingent negative variation preceding antisaccades in schizophrenia , 2000, Biological Psychiatry.

[2]  E. Basar,et al.  Brain oscillations in perception and memory. , 2000, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[3]  A. Berthoz,et al.  An anatomical landmark for the supplementary eye fields in human revealed with functional magnetic resonance imaging. , 1999, Cerebral cortex.

[4]  W. Skrandies,et al.  Electroencephalographic cortical oscillations and saccadic eye movements in humans , 1999, Neuroscience Letters.

[5]  D. Levy,et al.  Differences in cerebral activation during smooth pursuit and saccadic eye movements using positron-emission tomography , 1998, Biological Psychiatry.

[6]  R M Müri,et al.  Functional organisation of saccades and antisaccades in the frontal lobe in humans: a study with echo planar functional magnetic resonance imaging , 1998, Journal of neurology, neurosurgery, and psychiatry.

[7]  Valentino Bettinardi,et al.  Neural control of fast-regular saccades and antisaccades: an investigation using positron emission tomography , 1997, Experimental Brain Research.

[8]  W. Oertel,et al.  Functional MRI mapping of occipital and frontal cortical activity during voluntary and imagined saccades , 1997, Neurology.

[9]  V. Jousmäki,et al.  Magnetic source imaging during a visually guided task , 1996, Neuroreport.

[10]  A. Berthoz,et al.  Functional Anatomy of a Prelearned Sequence of Horizontal Saccades in Humans , 1996, The Journal of Neuroscience.

[11]  I. Evdokimidis,et al.  Cortical potentials with antisaccades. , 1996, Electroencephalography and clinical neurophysiology.

[12]  Anna C. Nobre,et al.  Cortical Activation in the Human Brain during Lateral Saccades Using EPISTAR Functional Magnetic Resonance Imaging , 1996, NeuroImage.

[13]  Richard S. J. Frackowiak,et al.  Cortical control of saccades and fixation in man. A PET study. , 1994, Brain : a journal of neurology.

[14]  M. D. Sanders The Neurology of Eye Movements , 1984 .

[15]  D. Lehmann,et al.  Reference-free identification of components of checkerboard-evoked multichannel potential fields. , 1980, Electroencephalography and clinical neurophysiology.

[16]  B. J. McCurtain,et al.  Dorsal cortical regions subserving visually guided saccades in humans: an fMRI study. , 1998, Cerebral cortex.

[17]  M. Mintun,et al.  Positron emission tomography study of voluntary saccadic eye movements and spatial working memory. , 1996, Journal of neurophysiology.

[18]  C. Pierrot-Deseilligny,et al.  Saccade and smooth-pursuit impairment after cerebral hemispheric lesions. , 1994, European neurology.