Profound Amnesia After Damage to the Medial Temporal Lobe: A Neuroanatomical and Neuropsychological Profile of Patient E. P.

E. P. became profoundly amnesic in 1992 after viral encephalitis, which damaged his medial temporal lobe bilaterally. Because of the rarity of such patients, we have performed a detailed neuroanatomical analysis of E. P.'s lesion using magnetic resonance imaging, and we have assessed his cognitive abilities with a wide range of neuropsychological tests. Finally, we have compared and contrasted the findings for E. P. with the noted amnesic patient H.M, whose surgical lesion is strikingly similar to E. P.'s lesion.

[1]  B T Hyman,et al.  H. M.’s Medial Temporal Lobe Lesion: Findings from Magnetic Resonance Imaging , 1997, The Journal of Neuroscience.

[2]  C. Price,et al.  Three Distinct Ventral Occipitotemporal Regions for Reading and Object Naming , 1999, NeuroImage.

[3]  N Butters,et al.  Comparisons of verbal fluency tasks in the detection of dementia of the Alzheimer type. , 1992, Archives of neurology.

[4]  M. B. Bender,et al.  Performance of complex visual tasks after cerebral lesions. , 1951, The Journal of nervous and mental disease.

[5]  J. A. Horel.  The neuroanatomy of amnesia. A critique of the hippocampal memory hypothesis. , 1978, Brain : a journal of neurology.

[6]  M. Yamada,et al.  [Dementia rating scale]. , 1997, Nihon rinsho. Japanese journal of clinical medicine.

[7]  S. Corkin.  Lasting Consequences of Bilateral Medial Temporal Lobectomy: Clinical Course and Experimental Findings in H.M. , 1984 .

[8]  Donald G. MacKay,et al.  H.M. Revisited: Relations between Language Comprehension, Memory, and the Hippocampal System , 1998, Journal of Cognitive Neuroscience.

[9]  L. Squire,et al.  Learning about categories in the absence of memory. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[10]  L R Squire,et al.  Intact perceptual memory in the absence of conscious memory. , 1997, Behavioral neuroscience.

[11]  L. Squire,et al.  Encapsulation of Implicit and Explicit Memory in Sequence Learning , 1998, Journal of Cognitive Neuroscience.

[12]  A. Baddeley,et al.  Amnesia and the distinction between long- and short-term memory. , 1970 .

[13]  A P Shimamura,et al.  Cognitive impairment following frontal lobe damage and its relevance to human amnesia. , 1989, Behavioral neuroscience.

[14]  H. Damasio,et al.  Wisconsin Card Sorting Test performance as a measure of frontal lobe damage. , 1991, Journal of clinical and experimental neuropsychology.

[15]  P. Osterrieth.  Le test de copie d'une figure complexe , 1944 .

[16]  D. Amaral,et al.  Three Cases of Enduring Memory Impairment after Bilateral Damage Limited to the Hippocampal Formation , 1996, The Journal of Neuroscience.

[17]  Michael D. Kopelman,et al.  Handbook of memory disorders , 1995 .

[18]  S. Breedin.  Reversal of the concreteness effect in a patient with semantic dementia , 1994 .

[19]  L. Squire,et al.  Emotional perception and memory in amnesia. , 1997, Neuropsychology.

[20]  L R Squire,et al.  Retrograde Amnesia for Facts and Events: Findings from Four New Cases , 1998, The Journal of Neuroscience.

[21]  A. Mayes,et al.  Human organic memory disorders , 1988 .

[22]  L. Cermak.  The encoding capacity of a patient with amnesia due to encephalitis , 1976, Neuropsychologia.

[23]  J D Gabrieli,et al.  Double dissociation of memory capacities after bilateral occipital-lobe or medial temporal-lobe lesions. , 1995, Brain : a journal of neurology.

[24]  K. J. Friston,et al.  Phonological retrieval and semantic processing during naming tasks , 1996, NeuroImage.

[25]  E. Kandel,et al.  Cognitive Neuroscience and the Study of Memory , 1998, Neuron.

[26]  G. V. Van Hoesen,et al.  Multimodal amnesic syndrome following bilateral temporal and basal forebrain damage. , 1985, Archives of neurology.

[27]  D. Amaral,et al.  Hippocampal abnormalities in amnesic patients revealed by high-resolution magnetic resonance imaging , 1989, Nature.

[28]  A D Baddeley,et al.  The autobiographical memory interview: a new assessment of autobiographical and personal semantic memory in amnesic patients. , 1989, Journal of clinical and experimental neuropsychology.

[29]  N. Butters.  Alcoholic Korsakoff's syndrome: some unresolved issues concerning etiology, neuropathology, and cognitive deficits. , 1985, Journal of clinical and experimental neuropsychology.

[30]  L. Squire,et al.  Characterizing amnesic patients for neurobehavioral study. , 1986, Behavioral neuroscience.

[31]  H. Coslett,et al.  Intact Perceptual Priming in a Patient with Damage to the Anterior Inferior Temporal Lobes , 1997, Journal of Cognitive Neuroscience.

[32]  R W Cox,et al.  AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. , 1996, Computers and biomedical research, an international journal.

[33]  L. Cermak,et al.  Alcoholic Korsakoff's Syndrome: An Information-Processing Approach to Amnesia , 1980 .

[34]  M. J. Riddoch,et al.  Visual object processing in optic aphasia: a case of semantic access agnosia , 1987 .

[35]  Larry R. Squire,et al.  Memory for places learned long ago is intact after hippocampal damage , 1999, Nature.

[36]  E. Kaplan,et al.  The Boston naming test , 2001 .

[37]  D. Salmon,et al.  Semantic memory impairment in Alzheimer's disease: Failure of access or degraded knowledge? , 1992, Neuropsychologia.

[38]  J. Lackner.  Observations on the speech processing capabilities of an amnesic patient: several aspects of H.M.'s language function. , 1974, Neuropsychologia.

[39]  Rosaleen A. McCarthy,et al.  The fractionation of retrograde amnesia , 1988, Brain and Cognition.

[40]  C. B. Cave,et al.  Intact verbal and nonverbal short‐term memory following damage to the human hippocampus , 1992, Hippocampus.

[41]  Jean Delay,et al.  Les maladies de la mémoire , 1949 .

[42]  N. Cohen,et al.  Forgetting in H.M.: A second look , 1987, Neuropsychologia.

[43]  W. Scoville,et al.  LOSS OF RECENT MEMORY AFTER BILATERAL HIPPOCAMPAL LESIONS , 1957, Journal of neurology, neurosurgery, and psychiatry.

[44]  Richard S. J. Frackowiak,et al.  Functional anatomy of a common semantic system for words and pictures , 1996, Nature.

[45]  R A Koeppe,et al.  Absence of normal activation of the left anterior fusiform gyrus during naming in left temporal lobe epilepsy , 1998, Neurology.

[46]  L. Squire,et al.  The human perirhinal cortex and recognition memory , 1998, Hippocampus.

[47]  L R Squire,et al.  Detection and explanation of sentence ambiguity are unaffected by hippocampal lesions but are impaired by larger temporal lobe lesions , 2000, Hippocampus.

[48]  Suzanne Corkin,et al.  Dissociations Among Structural-Perceptual, Lexical-Semantic, and Event-Fact Memory Systems in Alzheimer, Amnesic, and Normal Subjects , 1994, Cortex.

[49]  J. Hodges,et al.  Is semantic memory consistently impaired early in the course of Alzheimer's disease? Neuroanatomical and diagnostic implications , 1995, Neuropsychologia.

[50]  L. Squire,et al.  Recognition memory and familiarity judgments in severe amnesia: no evidence for a contribution of repetition priming. , 2000, Behavioral neuroscience.

[51]  L R Squire,et al.  When amnesic patients perform well on recognition memory tests. , 1997, Behavioral neuroscience.

[52]  Ny.  Emotions and Memory , 1943 .