Oxidative stress-mediated cytotoxicity and metabolism of T-2 toxin and deoxynivalenol in animals and humans: an update

[1]  W. Bao,et al.  Deoxynivalenol induced oxidative stress and genotoxicity in human peripheral blood lymphocytes. , 2014, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[2]  Y. Tao,et al.  Metabolism, distribution, and excretion of deoxynivalenol with combined techniques of radiotracing, high-performance liquid chromatography ion trap time-of-flight mass spectrometry, and online radiometric detection. , 2014, Journal of agricultural and food chemistry.

[3]  X. Qiu,et al.  T-2 toxin is hydroxylated by chicken CYP3A37. , 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[4]  Lei Zhang,et al.  Proteomic changes in chicken primary hepatocytes exposed to T‐2 toxin are associated with oxidative stress and mitochondrial enhancement , 2013, Proteomics.

[5]  Suxia Zhang,et al.  Metabolic pathways of T-2 toxin in in vivo and in vitro systems of Wistar rats. , 2013, Journal of agricultural and food chemistry.

[6]  F. Berthiller,et al.  Characterization of three deoxynivalenol sulfonates formed by reaction of deoxynivalenol with sulfur reagents. , 2013, Journal of agricultural and food chemistry.

[7]  K. Boussery,et al.  The mycotoxin T-2 inhibits hepatic cytochrome P4503A activity in pigs. , 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[8]  V. Dohnal,et al.  Trichothecenes: structure-toxic activity relationships. , 2013, Current drug metabolism.

[9]  R. Krska,et al.  New insights into the human metabolism of the Fusarium mycotoxins deoxynivalenol and zearalenone. , 2013, Toxicology letters.

[10]  H. Tsubone,et al.  Toxic effects of T-2 toxin and deoxynivalenol on the mitochondrial electron transport system of cardiomyocytes in rats. , 2013, The Journal of toxicological sciences.

[11]  Jun Jiang,et al.  Chicken Cytochrome P450 1A5 Is the Key Enzyme for Metabolizing T-2 Toxin to 3′OH-T-2 , 2013, International journal of molecular sciences.

[12]  K. Boussery,et al.  Toxic effects of dietary exposure to T-2 toxin on intestinal and hepatic biotransformation enzymes and drug transporter systems in broiler chickens. , 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[13]  K. Sinha,et al.  Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis , 2013, Archives of Toxicology.

[14]  X. Cui,et al.  Mycotoxin-Containing Diet Causes Oxidative Stress in the Mouse , 2013, PloS one.

[15]  H. Humpf,et al.  Influence of T-2 and HT-2 Toxin on the Blood-Brain Barrier In Vitro: New Experimental Hints for Neurotoxic Effects , 2013, PloS one.

[16]  C. Fæste,et al.  Enzyme-assisted synthesis and structural characterization of the 3-, 8-, and 15-glucuronides of deoxynivalenol. , 2013, Journal of agricultural and food chemistry.

[17]  M. Gekle,et al.  Neurotoxic potential and cellular uptake of T-2 toxin in human astrocytes in primary culture. , 2013, Chemical research in toxicology.

[18]  A. Richardson,et al.  The Human Fecal Microbiota Metabolizes Deoxynivalenol and Deoxynivalenol-3-Glucoside and May Be Responsible for Urinary Deepoxy-Deoxynivalenol , 2013, Applied and Environmental Microbiology.

[19]  M. Ishizaka,et al.  Bacterial Cytochrome P450 System Catabolizing the Fusarium Toxin Deoxynivalenol , 2012, Applied and Environmental Microbiology.

[20]  P. L. Lakshmana Rao,et al.  T-2 toxin induced skin inflammation and cutaneous injury in mice. , 2012, Toxicology.

[21]  V. Adam,et al.  Study of deoxynivalenol effect on metallothionein and glutathione levels, antioxidant capacity, and glutathione-S-transferase and liver enzymes activity in rats , 2012, Chemical Papers.

[22]  R. Krska,et al.  Investigation of the hepatic glucuronidation pattern of the Fusarium mycotoxin deoxynivalenol in various species. , 2012, Chemical research in toxicology.

[23]  R. Krska,et al.  Stable isotopic labelling-assisted untargeted metabolic profiling reveals novel conjugates of the mycotoxin deoxynivalenol in wheat , 2012, Analytical and Bioanalytical Chemistry.

[24]  F. Berthiller,et al.  Masked mycotoxins: A review , 2012, Molecular nutrition & food research.

[25]  H. Humpf,et al.  HT-2 toxin 4-glucuronide as new T-2 toxin metabolite: enzymatic synthesis, analysis, and species specific formation of T-2 and HT-2 toxin glucuronides by rat, mouse, pig, and human liver microsomes. , 2012, Journal of agricultural and food chemistry.

[26]  R. Krska,et al.  Metabolism of the masked mycotoxin deoxynivalenol-3-glucoside in rats , 2012, Toxicology letters.

[27]  C. Chen,et al.  Oxidant damage in Kashin‐Beck disease and a rat Kashin‐Beck disease model by employing T‐2 toxin treatment under selenium deficient conditions , 2012, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[28]  H. Humpf,et al.  Intestinal metabolism of T-2 toxin in the pig cecum model , 2012, Mycotoxin Research.

[29]  Qiang Li,et al.  T-2 Toxin Contamination in Grains and Selenium Concentration in Drinking Water and Grains in Kaschin–Beck Disease Endemic Areas of Qinghai Province , 2012, Biological Trace Element Research.

[30]  M. Gekle,et al.  Identification and apoptotic potential of T-2 toxin metabolites in human cells. , 2012, Journal of agricultural and food chemistry.

[31]  S. Peng,et al.  T-2 toxin induces apoptosis in differentiated murine embryonic stem cells through reactive oxygen species-mediated mitochondrial pathway , 2012, Apoptosis.

[32]  R. Krska,et al.  Assessment of human deoxynivalenol exposure using an LC-MS/MS based biomarker method. , 2012, Toxicology letters.

[33]  Y. Sugita‐Konishi,et al.  Thioredoxin-1 contributes to protection against DON-induced oxidative damage in HepG2 cells , 2012, Mycotoxin Research.

[34]  L. Gille,et al.  Genotoxic effects of deoxynivalenol in broiler chickens fed low-protein feeds. , 2012, Poultry science.

[35]  Xiaochun Wang,et al.  Contamination Level of T-2 and HT-2 Toxin in Cereal Crops from Aba Area in Sichuan Province, China , 2012, Bulletin of Environmental Contamination and Toxicology.

[36]  R. Krska,et al.  Hydrolytic fate of deoxynivalenol-3-glucoside during digestion , 2011, Toxicology letters.

[37]  Lingli Huang,et al.  A comparison of hepatic in vitro metabolism of T-2 toxin in rats, pigs, chickens, and carp , 2011, Xenobiotica; the fate of foreign compounds in biological systems.

[38]  K. Uetsuka,et al.  Mechanisms of Mycotoxin-Induced Neurotoxicity through Oxidative Stress-Associated Pathways , 2011, International journal of molecular sciences.

[39]  S. Trump,et al.  T-2 toxin is a cytochrome P450 1A1 inducer and leads to MAPK/p38- but not aryl hydrocarbon receptor-dependent interleukin-8 secretion in the human intestinal epithelial cell line Caco-2. , 2011, Toxicology.

[40]  Jun Jiang,et al.  Integrated Transcriptional and Proteomic Analysis with In Vitro Biochemical Assay Reveal the Important Role of CYP3A46 in T-2 Toxin Hydroxylation in Porcine Primary Hepatocytes* , 2011, Molecular & Cellular Proteomics.

[41]  R. Krska,et al.  Direct quantification of deoxynivalenol glucuronide in human urine as biomarker of exposure to the Fusarium mycotoxin deoxynivalenol , 2011, Analytical and bioanalytical chemistry.

[42]  S. Peng,et al.  T-2 toxin induces apoptosis in ovarian granulosa cells of rats through reactive oxygen species-mediated mitochondrial pathway. , 2011, Toxicology letters.

[43]  Suxia Zhang,et al.  T-2 toxin, a trichothecene mycotoxin: review of toxicity, metabolism, and analytical methods. , 2011, Journal of agricultural and food chemistry.

[44]  P. Rao,et al.  Brain oxidative stress after dermal and subcutaneous exposure of T-2 toxin in mice. , 2010, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[45]  Xiaohu Ge,et al.  The catalytic activity of cytochrome P450 3A22 is critical for the metabolism of T-2 toxin in porcine reservoirs , 2010 .

[46]  P. Wiesenfeld,et al.  Comparative hepatotoxicity of deoxynivalenol in rat, mouse and human liver cells in culture , 2010, Journal of applied toxicology : JAT.

[47]  R. Krishnaswamy,et al.  Lutein protects HT-29 cells against Deoxynivalenol-induced oxidative stress and apoptosis: prevention of NF-kappaB nuclear localization and down regulation of NF-kappaB and Cyclo-Oxygenase-2 expression. , 2010, Free radical biology & medicine.

[48]  S. Kahlert,et al.  Studies on the toxicity of deoxynivalenol (DON), sodium metabisulfite, DON-sulfonate (DONS) and de-epoxy-DON for porcine peripheral blood mononuclear cells and the Intestinal Porcine Epithelial Cell lines IPEC-1 and IPEC-J2, and on effects of DON and DONS on piglets. , 2010, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[49]  J. Fisher,et al.  Determinants of urinary deoxynivalenol and de-epoxy deoxynivalenol in male farmers from Normandy, France. , 2010, Journal of agricultural and food chemistry.

[50]  M. Hajlaoui,et al.  Pathway of deoxynivalenol-induced apoptosis in human colon carcinoma cells. , 2009, Toxicology.

[51]  Liping Jiang,et al.  The role of oxidative stress in deoxynivalenol-induced DNA damage in HepG2 cells. , 2009, Toxicon : official journal of the International Society on Toxinology.

[52]  V. Dohnal,et al.  Metabolic pathways of trichothecenes. , 2009, Drug metabolism reviews.

[53]  P. L. Lakshmana Rao,et al.  Oxidative stress induction by T-2 toxin causes DNA damage and triggers apoptosis via caspase pathway in human cervical cancer cells. , 2009, Toxicology.

[54]  S. Santhosh,et al.  Oxidative damage and gene expression profile of antioxidant enzymes after T‐2 toxin exposure in mice , 2009, Journal of biochemical and molecular toxicology.

[55]  M. Gekle,et al.  Metabolism and cytotoxic effects of T-2 toxin and its metabolites on human cells in primary culture. , 2009, Toxicology.

[56]  H. Humpf,et al.  Structural elucidation of T-2 toxin thermal degradation products and investigations toward their occurrence in retail food. , 2009, Journal of agricultural and food chemistry.

[57]  Hermann Stuppner,et al.  In vitro evaluation of the chemoprotective action mechanisms of leontopodic acid against aflatoxin B1 and deoxynivalenol‐induced cell damage , 2009, Journal of applied toxicology : JAT.

[58]  S. Chirtel,et al.  Rat liver clone‐9 cells in culture as a model for screening hepatotoxic potential of food‐related products: hepatotoxicity of deoxynivalenol , 2008, Journal of applied toxicology : JAT.

[59]  P. Galtier,et al.  Subclinical doses of T-2 toxin impair acquired immune response and liver cytochrome P450 in pigs. , 2008, Toxicology.

[60]  J. Salobir,et al.  The effect of vitamin E supplementation on reduction of lymphocyte DNA damage induced by T-2 toxin and deoxynivalenol in weaned pigs , 2008 .

[61]  P. Murphy,et al.  Synthesis and characterization of deoxynivalenol glucuronide: its comparative immunotoxicity with deoxynivalenol. , 2007, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[62]  J. Pestka.  Deoxynivalenol: Toxicity, mechanisms and animal health risks , 2007 .

[63]  A. Levart,et al.  Dose-dependent effects of T-2 toxin on performance, lipid peroxidation, and genotoxicity in broiler chickens. , 2007, Poultry science.

[64]  Yoshiko Yokoyama,et al.  T-2 toxin initially activates caspase-2 and induces apoptosis in U937 cells. , 2007, Toxicology letters.

[65]  A. Levart,et al.  The role of dietary nucleotides in reduction of DNA damage induced by T-2 toxin and deoxynivalenol in chicken leukocytes. , 2006, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[66]  M. Ladjimi,et al.  Induction of Hsp 70 in Vero cells in response to mycotoxins cytoprotection by sub-lethal heat shock and by Vitamin E. , 2006, Toxicology letters.

[67]  S. Dänicke,et al.  Bioavailability of the Fusarium toxin deoxynivalenol (DON) from naturally contaminated wheat for the pig. , 2006, Toxicology letters.

[68]  P. Galtier,et al.  Effect of various doses of deoxynivalenol on liver xenobiotic metabolizing enzymes in mice. , 2006, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[69]  S. Moukha,et al.  Comparative study of cytotoxicity and oxidative stress induced by deoxynivalenol, zearalenone or fumonisin B1 in human intestinal cell line Caco-2. , 2005, Toxicology.

[70]  N. Kiyosawa,et al.  Microarray analysis of T-2 toxin-induced liver, placenta and fetal liver lesions in pregnant rats. , 2005, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

[71]  R. Krska,et al.  Masked mycotoxins: determination of a deoxynivalenol glucoside in artificially and naturally contaminated wheat by liquid chromatography-tandem mass spectrometry. , 2005, Journal of agricultural and food chemistry.

[72]  C. Wild,et al.  Development of a urinary biomarker of human exposure to deoxynivalenol. , 2003, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[73]  R. R. Marquardt,et al.  Effect of T-2 toxin on in vivo lipid peroxidation and vitamin E status in mice. , 2002, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[74]  J. Matés,et al.  Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology. , 2000, Toxicology.

[75]  S. Sankari,et al.  Liver Enzyme Activities of Rats Exposed to Ochratoxin A and T-2 Toxin with Antioxidants , 2000, Bulletin of environmental contamination and toxicology.

[76]  A. Shimada,et al.  Effect of lycopene on lipid peroxidation and glutathione-dependent enzymes induced by T-2 toxin in vivo. , 1999, Toxicology letters.

[77]  P. Galtier,et al.  The effects of T-2 toxin exposure on liver drug metabolizing enzymes in rabbit. , 1998, Food additives and contaminants.

[78]  M. Ahotupa,et al.  Protective effect of antioxidants against free radical-mediated lipid peroxidation induced by DON or T-2 toxin. , 1994, Zentralblatt fur Veterinarmedizin. Reihe A.

[79]  F. Fonnum,et al.  Metabolism of T-2 toxin by blood cell carboxylesterases. , 1988, Biochemical pharmacology.

[80]  D. Veira,et al.  Metabolic fate and elimination in milk, urine and bile of deoxynivalenol following administration to lactating sheep. , 1987, Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.

[81]  E. Jeffery,et al.  Lack of hepatic microsomal metabolism of deoxynivalenol and its metabolite, DOM-1. , 1987, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[82]  J. Young,et al.  Detoxification of deoxynivalenol with sodium bisulfite and evaluation of the effects when pure mycotoxin or contaminated corn was treated and given to pigs , 1987 .

[83]  F. Fonnum,et al.  Metabolism of T-2 toxin by rat liver carboxylesterase. , 1986, Biochemical pharmacology.

[84]  R. Vesonder,et al.  Subchronic toxicity of vomitoxin in Sprague-Dawley rats. , 1985, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[85]  T. Yoshizawa,et al.  In vitro formation of 3'-hydroxy T-2 and 3'-hydroxy HT-2 toxins from T-2 toxin by liver homogenates from mice and monkeys , 1984, Applied and environmental microbiology.

[86]  C. Klaassen,et al.  Inhibition of lipid peroxidation without prevention of cellular injury in isolated rat hepatocytes. , 1981, Toxicology and applied pharmacology.

[87]  P. Rao.  Who Food Additives Series , 1973 .

[88]  Y. Tao,et al.  High risk of embryo-fetal toxicity: placental transfer of T-2 toxin and its major metabolite HT-2 toxin in BeWo cells. , 2014, Toxicological sciences : an official journal of the Society of Toxicology.

[89]  C. Wild,et al.  Assessment of deoxynivalenol metabolite profiles in UK adults. , 2011, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[90]  Miroslav Pohanka,et al.  Chemical warfare agents. , 2010, EXS.

[91]  V. Dohnal,et al.  Metabolic pathways of T-2 toxin. , 2008, Current drug metabolism.

[92]  Joint Fao,et al.  Safety evaluation of certain mycotoxins in food , 2001 .

[93]  R. Tukey,et al.  Human UDP-glucuronosyltransferases: metabolism, expression, and disease. , 2000, Annual review of pharmacology and toxicology.

[94]  Tutel'ian Va,et al.  [Effect of dietary selenium on the activity of UDP-glucuronosyltransferases and metabolism of mycotoxin deoxynivalenol in rats]. , 1998 .

[95]  L. Kravchenko,et al.  [Effect of dietary selenium on the activity of UDP-glucuronosyltransferases and metabolism of mycotoxin deoxynivalenol in rats]. , 1998, Voprosy pitaniia.

[96]  W. Forth,et al.  Role of lipid peroxidation in the toxicity of T-2 toxin. , 1987, Toxicon : official journal of the International Society on Toxinology.

[97]  S. K. Suneja,et al.  T-2 toxin induced changes in liver and serum enzymes of rats. , 1987, Toxicon : official journal of the International Society on Toxinology.

[98]  S. K. Suneja,et al.  Effects of T-2 toxin on glucose and tryptophan uptake and intestinal mucosal enzymes. , 1984, Toxicon : official journal of the International Society on Toxinology.