Relationship between cell size and specific thrombopoietin productivity in chinese hamster ovary cells during dihydrofolate reductase-mediated gene amplification

[1]  G. M. Lee,et al.  Clonal variability within dihydrofolate reductase-mediated gene amplified Chinese hamster ovary cells: stability in the absence of selective pressure. , 1998, Biotechnology and bioengineering.

[2]  C. Ryu,et al.  Characterization of chimeric antibody producing CHO cells in the course of dihydrofolate reductase-mediated gene amplification and their stability in the absence of selective pressure. , 1998, Biotechnology and bioengineering.

[3]  J Lehmann,et al.  Cell size distribution as a parameter for the predetermination of exponential growth during repeated batch cultivation of CHO cells. , 1997, Biotechnology and bioengineering.

[4]  C. Petropoulos,et al.  Plasmid integration, amplification and cytogenetics in CHO cells: questions and comments. , 1994, Biologicals : journal of the International Association of Biological Standardization.

[5]  M. Reff High-level production of recombinant immunoglobulins in mammalian cells. , 1993, Current opinion in biotechnology.

[6]  Amit Varma,et al.  Production of monoclonal antibody using free‐suspended and immobilized hybridoma cells: Effect of serum , 1991, Biotechnology and bioengineering.

[7]  R. Mutharasan,et al.  Cell cycle‐ and growth phase‐dependent variations in size distribution, antibody productivity, and oxygen demand in hybridoma cultures , 1990, Biotechnology and bioengineering.

[8]  K. K. Frame,et al.  Cell volume measurement as an estimation of mammalian cell biomass , 1990, Biotechnology and bioengineering.

[9]  Y. Assaraf,et al.  Identification of methotrexate transport deficiency in mammalian cells using fluoresceinated methotrexate and flow cytometry. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[10]  P. Sharp,et al.  Evolution of chromosomal regions containing transfected and amplified dihydrofolate reductase sequences , 1983, Molecular and cellular biology.

[11]  W. Flintoff,et al.  Methotrexate-resistant Chinese hamster ovary cells contain a dihydrofolate reductase with an altered affinity for methotrexate. , 1980, Biochemistry.

[12]  G. Lee,et al.  Key Determinants in the Occurrence of Clonal Variation in Humanized Antibody Expression of CHO Cells during Dihydrofolate Reductase Mediated Gene Amplification , 2001, Biotechnology progress.

[13]  J. Trill,et al.  Production of monoclonal antibodies in COS and CHO cells. , 1995, Current opinion in biotechnology.