Replacement of the hip in children with a tumor in the proximal part of the femur.

BACKGROUND Children rarely require hip replacement, and therefore very little is known about the most effective procedure for children who require hip replacement after proximal femoral resection for a tumor. METHODS We reviewed the outcome of forty hip replacements in children between two and fifteen years old who had a proximal femoral replacement for malignant disease. Twenty-one children survived the illness and were followed for three to twenty-one years. Cemented acetabular components were used initially to restore hip function, but, in more recent procedures, unipolar replacements and uncemented implants were used. RESULTS Children who were over the age of eleven years at the time of surgery had a rate of failure (defined as revision of the acetabular component) of 25% at ten years compared with a rate of 75% in younger children. Unipolar replacements in children of all ages failed by ten years, either because of pain or subluxation that led to revision. In children over the age of eleven years, both cemented and uncemented acetabular implants performed well. CONCLUSIONS The preferred method for restoration of hip function in children under the age of eleven years following proximal femoral resection for a tumor remains unclear. We recommend that at the initial hip surgery an attempt should be made to cause as little damage as possible to the acetabulum, but most children will inevitably need revision surgery as they get older. We hope that this study will guide others in their decision-making with regard to this relatively rare condition.

[1]  J. Spinelli,et al.  Risk of a second malignant neoplasm among 5‐year survivors of cancer in childhood and adolescence in British Columbia, Canada , 2007, Pediatric blood & cancer.

[2]  L. Strong,et al.  Secondary sarcomas in childhood cancer survivors: a report from the Childhood Cancer Survivor Study. , 2007, Journal of the National Cancer Institute.

[3]  C. Case,et al.  Metallic debris from orthopaedic implants , 2007, The Lancet.

[4]  M. van Glabbeke,et al.  Improvement in histologic response but not survival in osteosarcoma patients treated with intensified chemotherapy: a randomized phase III trial of the European Osteosarcoma Intergroup. , 2007, Journal of the National Cancer Institute.

[5]  C. Ranawat,et al.  Serum metal levels and bearing surfaces in total hip arthroplasty. , 2006, The Journal of arthroplasty.

[6]  T. Xenakis,et al.  Total Hip Arthroplasty in Children With Juvenile Chronic Arthritis: Long-Term Results , 2006, Journal of pediatric orthopedics.

[7]  A. Adili,et al.  Predictive risk factors for stiff knees in total knee arthroplasty. , 2006, The Journal of arthroplasty.

[8]  J. Healey,et al.  Acetabular development after bipolar hemiarthroplasty for osteosarcoma in children. , 2005, The Journal of bone and joint surgery. British volume.

[9]  P. Unwin,et al.  Metal ion levels after metal-on-metal proximal femoral replacements: a 30-year follow-up. , 2005, The Journal of bone and joint surgery. British volume.

[10]  R. Grimer,et al.  Management and outcome after local recurrence of osteosarcoma. , 2005, European journal of cancer.

[11]  H. B. Marsden,et al.  Long-term population-based risks of second malignant neoplasms after childhood cancer in Britain , 2004, British Journal of Cancer.

[12]  R. Grimer,et al.  Extensible Endoprostheses for Bone Tumors of the Proximal Femur in Children , 2003, Journal of pediatric orthopedics.

[13]  Marco Manfrini,et al.  Original biological reconstruction of the hip in a 4-year-old girl , 2003, The Lancet.

[14]  R. Grimer,et al.  Surgical outcomes in osteosarcoma. , 2002, The Journal of bone and joint surgery. British volume.

[15]  E. Gozzi,et al.  Modular prosthetic replacement of the proximal femur after resection of a bone tumour a long-term follow-up. , 2001, The Journal of bone and joint surgery. British volume.

[16]  T. Sculco,et al.  Failure of bipolar hemiarthroplasty: a retrospective review of 31 consecutive bipolar prostheses converted to total hip arthroplasty. , 2001, American journal of orthopedics.

[17]  J. Somville,et al.  Clinical relevance of acetabular erosion in young patients with a bipolar hip prosthesis. , 2000, Acta orthopaedica Belgica.

[18]  A. Craft,et al.  Prognostic factors in Ewing's tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing's Sarcoma Study Group. , 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[19]  W. Winkelmann Type-B-IIIa Hip Rotationplasty: An Alternative Operation for the Treatment of Malignant Tumors of the Femur in Early Childhood* , 2000, The Journal of bone and joint surgery. American volume.

[20]  R. Grimer,et al.  Endoprosthetic replacement for primary malignant tumors of the proximal femur. , 1999, Clinical orthopaedics and related research.

[21]  P. Walker,et al.  Use of Extendable Total Femoral Replacements in Children With Malignant Bone Tumors , 1998, Clinical orthopaedics and related research.

[22]  T. Ochi,et al.  Acetabular osteolysis and migration in bipolar arthroplasty of the hip: five- to 13-year follow-up study. , 1997, The Journal of bone and joint surgery. British volume.

[23]  P S Walker,et al.  Aseptic loosening in cemented custom-made prosthetic replacements for bone tumours of the lower limb. , 1996, The Journal of bone and joint surgery. British volume.

[24]  S. Weinstein Congenital hip dislocation. Long-range problems, residual signs, and symptoms after successful treatment. , 1992, Clinical Orthopaedics and Related Research.

[25]  K. Murayama,et al.  Entrapment of the saphenous nerve by branches of the femoral vessels. A report of two cases. , 1991, Journal of Bone and Joint Surgery. American volume.

[26]  E. B. Carpenter Resection of the proximal third of the femur for chondrosarcoma: replacement with a metallic prosthesis. A note after fifteen years of follow-up. , 1987, Journal of Bone and Joint Surgery. American volume.

[27]  B. Ansell,et al.  Total hip replacement in children with juvenile chronic arthritis. , 1986, The Journal of bone and joint surgery. British volume.

[28]  M. Devas,et al.  Prevention of acetabular erosion after hemiarthroplasty for fractured neck of femur. , 1983, The Journal of bone and joint surgery. British volume.

[29]  L. Lidgren,et al.  Total hip replacement in juvenile chronic arthritis. , 1983, Acta orthopaedica Scandinavica.

[30]  D. Springfield,et al.  Pseudotumor of the arm associated with rupture of silicone-gel breast prostheses. Report of two cases. , 1983, The Journal of bone and joint surgery. American volume.

[31]  J. Ogden,et al.  Injury to the acetabular triradiate physeal cartilage. , 1982, The Journal of bone and joint surgery. American volume.

[32]  E. B. Carpenter Resection of the proximal third of the femur for chondrosarcoma in a child: replacement with a metallic prosthesis. Case report. , 1979, Journal of Bone and Joint Surgery. American volume.

[33]  I. Ponseti Growth and development of the acetabulum in the normal child. Anatomical, histological, and roentgenographic studies. , 1978, The Journal of bone and joint surgery. American volume.

[34]  E. Salvati,et al.  Premature closure of the triradiate cartilage. A case report and animal experiment. , 1977, Clinical orthopaedics and related research.

[35]  N. Harris Acetabular growth potential in congenital dislocation of the hip and some factors upon which it may depend. , 1976, Clinical orthopaedics and related research.