Reliability and accuracy of heart rate variability metrics versus ECG segment duration

Despite the exponential growth in heart rate variability (HRV) research, the reproducibility and reliability of HRV metrics continues to be debated. We estimated the reliability of 11 metrics calculated from 5 min records. We also compared the accuracy of the HRV metrics calculated from ECG records spanning 10 s to 10 min as compared with the metrics calculated from 5 min records. The mean heart rate was more reproducible and could be more accurately estimated from very short segments (<1 min) than any of the other HRV metrics. HRV metrics that effectively highpass filter the R–R interval series were more reliable than the other metrics and could be more accurately estimated from very short segments. This indicates that most of the HRV is caused by drift and nonstationary effects. Metrics that are sensitive to low frequency components of HRV have poor repeatability and cannot be estimated accurately from short segments (<10 min).

[1]  I. I. Christov,et al.  High-pass filtering of ECG signals using QRS elimination , 2006, Medical and Biological Engineering and Computing.

[2]  P. Stein,et al.  Stability of index of heart rate variability in patients with congestive heart failure. , 1995, American heart journal.

[3]  R. Cohen,et al.  Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control. , 1981, Science.

[4]  A Murray,et al.  Repeatability of measurements and sources of variability in tests of cardiovascular autonomic function , 1992, British heart journal.

[5]  Robert H. Wood,et al.  RELIABILITY OF HEART RATE VARIABILITY DURING DYNAMIC HANDGRIP EXERCISE , 2001 .

[6]  A Skyschally,et al.  [Poor reproducibility of parameters of heart rate variations]. , 1992, Zeitschrift fur Kardiologie.

[7]  Brahm Goldstein,et al.  Heart rate variability in critical illness and critical care , 2002, Current opinion in critical care.

[8]  G.B. Moody,et al.  PhysioNet: a Web-based resource for the study of physiologic signals , 2001, IEEE Engineering in Medicine and Biology Magazine.

[9]  S. Pincus,et al.  Randomness and degrees of irregularity. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[10]  A L Tonkin,et al.  REPRODUCIBILITY OF CONVENTIONAL AND POWER SPECTRAL MEASUREMENTS OF CARDIOVASCULAR SYMPATHETIC ACTIVATION IN NORMAL SUBJECTS , 1996, Clinical and experimental pharmacology & physiology.

[11]  R E Kalman,et al.  Not all (possibly) "random" sequences are created equal. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[12]  D Kerrigan,et al.  REPRODUCIBILITY OF HEART RATE VARIABILITY MEASURES DURING EXERCISE , 2001 .

[13]  Juha Hartikainen,et al.  Has Non-linear Analysis of Heart Rate Variability Any Practical Value? , 1999 .

[14]  F. Rengo,et al.  Reproducibility of short- and long-term Poincare plot parameters compared with frequency-domain HRV indexes in congestive heart failure , 1998, Computers in Cardiology 1998. Vol. 25 (Cat. No.98CH36292).

[15]  P. Vardas,et al.  Intraindividual Reproducibility of Heart Rate Variability Before and During Postural Tilt in Patients with Syncope of Unknown Origin , 1994, Pacing and clinical electrophysiology : PACE.

[16]  L A Wolfe,et al.  Reliability of noninvasive methods to measure cardiac autonomic function. , 1998, Canadian journal of applied physiology = Revue canadienne de physiologie appliquee.

[17]  B. Marks,et al.  Reproducibility of resting heart rate variability with short sampling periods. , 1999, Canadian journal of applied physiology = Revue canadienne de physiologie appliquee.

[18]  S. Malpas Neural influences on cardiovascular variability: possibilities and pitfalls. , 2002, American journal of physiology. Heart and circulatory physiology.

[19]  W D. Franke,et al.  REPRODUCIBILITY OF THE AUTONOMIC AND CARDIOVASCULAR RESPONSES TO MAXIMAL LOWER BODY NEGATIVE PRESSURE , 2001 .

[20]  G. Breithardt,et al.  Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. , 1996 .

[21]  P. Sleight,et al.  Physical activity influences heart rate variability and very-low-frequency components in Holter electrocardiograms. , 1996, Cardiovascular research.

[22]  A. Malliani,et al.  Heart rate variability. Standards of measurement, physiological interpretation, and clinical use , 1996 .

[23]  R. González,et al.  Reproducibility of heart rate variability from short-term recordings during five manoeuvres in normal subjects , 2003, Journal of medical engineering & technology.

[24]  D. Singer,et al.  Reproducibility and relation to mean heart rate of heart rate variability in normal subjects and in patients with congestive heart failure secondary to coronary artery disease. , 1991, The American journal of cardiology.

[25]  M. Urban,et al.  Short- and long-term reproducibility of autonomic measures in supine and standing positions. , 2004, Clinical science.

[26]  J. Fleiss,et al.  Intraclass correlations: uses in assessing rater reliability. , 1979, Psychological bulletin.

[27]  R W Barnes,et al.  A computer algorithm to impute interrupted heart rate data for the spectral analysis of heart rate variability--the ARIC study. , 1996, Computers and biomedical research, an international journal.

[28]  Marek Malik,et al.  Heart Rate Variability—State of The Art , 1999 .

[29]  K. McGraw,et al.  "Forming inferences about some intraclass correlations coefficients": Correction. , 1996 .

[30]  O Claudon,et al.  [Reproducibility of heart rate variability in the chronic phase of myocardial infarction]. , 1998, Archives des maladies du coeur et des vaisseaux.

[31]  Peter W Macfarlane,et al.  Can cardiac vagal tone be estimated from the 10-second ECG? , 2004, International journal of cardiology.

[32]  Angelo Tremblay,et al.  The reproducibility of power spectrum analysis of heart rate variability before and after a standardized meal , 2002, Physiology & Behavior.

[33]  I Daskalov,et al.  Improvement of resolution in measurement of electrocardiogram RR intervals by interpolation. , 1997, Medical engineering & physics.

[34]  E. Kaufman,et al.  Heart Rate Variability by Triangular Index in Infants Exposed Prenatally to Cocaine , 2002, Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc.

[35]  M Myrtek,et al.  Covariation and reliability of ECG parameters during 24-hour monitoring. , 1990, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[36]  P Jaillon,et al.  Repeatability of spectral components of short-term blood pressure and heart rate variability during acute sympathetic activation in healthy young male subjects. , 1997, Clinical science.

[37]  Ivaylo I Christov,et al.  Real time electrocardiogram QRS detection using combined adaptive threshold , 2004, Biomedical engineering online.

[38]  H Just,et al.  [Reproducibility of heart rate variability measurements in repeated 24-hour long-term ECG registration]. , 1993, Zeitschrift fur Kardiologie.

[39]  D Sapoznikov,et al.  Five minute recordings of heart rate variability for population studies: repeatability and age–sex characteristics , 1998, Heart.

[40]  M. Tarvainen,et al.  High-resolution QRS fiducial point corrections in sparsely sampled ECG recordings. , 2005, Physiological measurement.

[41]  I. Christov,et al.  Filtering of electromyogram artifacts from the electrocardiogram. , 1999, Medical engineering & physics.

[42]  E Länsimies,et al.  Day-to-day variability of cardiac autonomic regulation parameters in normal subjects. , 2008, Clinical physiology.

[43]  N. Armstrong,et al.  Reliability of heart rate variability measures at rest and during light exercise in children , 2003, British journal of sports medicine.

[44]  D Kromhout,et al.  Heart rate variability from short electrocardiographic recordings predicts mortality from all causes in middle-aged and elderly men. The Zutphen Study. , 1997, American journal of epidemiology.

[45]  A L Goldberger,et al.  Physiological time-series analysis: what does regularity quantify? , 1994, The American journal of physiology.

[46]  J. Gerritsen,et al.  Measures of cardiovascular autonomic nervous function: agreement, reproducibility, and reference values in middle age and elderly subjects , 2003, Diabetologia.

[47]  I I Christov,et al.  Electrocardiogram signal preprocessing for automatic detection of QRS boundaries. , 1999, Medical engineering & physics.

[48]  P Kligfield,et al.  Reproducibility of power spectral measures of heart rate variability obtained from short-term sampling periods. , 1994, The American journal of cardiology.

[49]  M Pagani,et al.  Relationship between repeated measures of hemodynamics, muscle sympathetic nerve activity, and their spectral oscillations. , 1997, Circulation.

[50]  M. P. Griffin,et al.  Sample entropy analysis of neonatal heart rate variability. , 2002, American journal of physiology. Regulatory, integrative and comparative physiology.

[51]  F Mastropasqua,et al.  Short- and long-term reproducibility of time and frequency domain heart rate variability measurements in normal subjects. , 1996, Cardiovascular research.

[52]  D. T. Kaplan,et al.  Aging and the complexity of cardiovascular dynamics. , 1991, Biophysical journal.

[53]  S M Pincus,et al.  Approximate entropy as a measure of system complexity. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[54]  Steven M. Pincus,et al.  Quantification of hormone pulsatility via an approximate entropy algorithm. , 1992, The American journal of physiology.

[55]  Steven M. Pincus Approximating Markov chains. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[56]  Alison B. Flatau,et al.  Reproducibility of the heart rate variability responses to graded lower body negative pressure , 2004, European Journal of Applied Physiology.

[57]  K. McGraw,et al.  Forming inferences about some intraclass correlation coefficients. , 1996 .

[58]  J. Saul,et al.  Beat-to-Beat Variations of Heart Rate Reflect Modulation of Cardiac Autonomic Outflow , 1990 .

[59]  A. Burger,et al.  Short- and long-term reproducibility of heart rate variability in patients with long-standing type I diabetes mellitus. , 1997, The American journal of cardiology.

[60]  F. Estafanous,et al.  Entropy measures of heart rate variation in conscious dogs. , 1998, American journal of physiology. Heart and circulatory physiology.

[61]  Steven M. Pincus Assessing Serial Irregularity and Its Implications for Health , 2001, Annals of the New York Academy of Sciences.

[62]  R Colombo,et al.  Reproducibility of heart rate variability measures in patients with chronic heart failure. , 1996, Clinical science.

[63]  Metin Akay,et al.  Approximate Entropy and its Application in Biosignal Analysis , 2000 .