A new classification for mandibular defects after oncological resection.

No universally accepted classification system exists for mandibular defects after oncological resection. Here, we discuss the scientific literature on classifications for mandibular defects that are sufficiently presented either pictorially or descriptively, and propose a new classification system based on these findings. Of 167 studies included in the data analysis, 49 of these reports sufficiently described the defect for analysis. These reports were analysed for classification, reconstruction, size of defect, number of osteotomies needed, and complications. On the basis of these findings, a new classification is proposed based on the four corners of the mandible (two angles and two canines): class I (lateral), class II (hemimandibulectomy), class III (anterior), and class IV (extensive). Further classes (Ic, IIc, and IVc) include condylectomy. The increasing defect class relates to the size of the defect, osteotomy rate, and functional and aesthetic outcome, and could guide the method of reconstruction.

[1]  K. Wolff,et al.  Experience with the osteocutaneous fibula flap: an analysis of 24 consecutive reconstructions of composite mandibular defects. , 1996, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

[2]  G. Tsakos Measures of health-related quality of life , 2002 .

[3]  D. Okay,et al.  Oromandibular reconstruction using microvascular composite flaps: report of 210 cases. , 1998, Archives of otolaryngology--head & neck surgery.

[4]  D. de Raucourt,et al.  Revascularized free scapular flaps in mandibular reconstruction. Report of 93 cases (April 1997 - October 2009). , 2010, Revue de laryngologie - otologie - rhinologie.

[5]  K. Notani,et al.  Three-phase bone scintigraphy and viability of vascularized bone grafts for mandibular reconstruction. , 2000, International journal of oral and maxillofacial surgery.

[6]  E. Santamaria,et al.  Fibula Osteoseptocutaneous Flap for Reconstruction of Osteoradionecrosis of the Mandible , 1998, Plastic and reconstructive surgery.

[7]  P. Gullane,et al.  Orofacial and Mandibular Reconstruction with the Iliac Crest Free Flap: A Review of 60 Cases and a New Method of Classification , 1989, Plastic and reconstructive surgery.

[8]  O. Militsakh,et al.  Use of the 2.0-mm Locking Reconstruction Plate in Primary Oromandibular Reconstruction after Composite Resection , 2004, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[9]  P. Feustel,et al.  Etiologic causes of late osteocutaneous free flap failures in oral cavity cancer reconstruction , 2012, The Laryngoscope.

[10]  J. J. Coleman,et al.  Mandibular reconstruction with composite microvascular tissue transfer. , 1990, American journal of surgery.

[11]  F. Wei,et al.  Dental Implant Outcome after Primary Implantation into Double-Barreled Fibula Osteoseptocutaneous Free Flap–Reconstructed Mandible , 2011, Plastic and reconstructive surgery.

[12]  B. Schmidt,et al.  Quality of life evaluation for patients receiving vascularized versus nonvascularized bone graft reconstruction of segmental mandibular defects. , 2008, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[13]  R. Zuker,et al.  Mandibular Reconstruction in Children Using the Vascularized Fibula , 1999, Journal of reconstructive microsurgery.

[14]  A. Kovács Influence of the Prosthetic Restoration Modality on Bone Loss Around Dental Implants Placed in Vascularized Iliac Bone Grafts for Mandibular Reconstruction , 2000, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[15]  M. Singer,et al.  A comparison of masticatory function in patients with or without reconstruction of the mandible , 1997, Head & neck.

[16]  James S. Brown,et al.  Comparison of miniplates and reconstruction plates in mandibular reconstruction , 2004, Head & neck.

[17]  M. Smith-Wheelock,et al.  The free scapular flap for head and neck reconstruction. , 1990, American journal of otolaryngology.

[18]  H. Reychler,et al.  Mandibular reconstruction with the free fibula osteocutaneous flap. , 1994, International journal of oral and maxillofacial surgery.

[19]  T. Poli,et al.  Rehabilitation with endosseous implants in fibula free-flap mandibular reconstruction: a case series of up to 10 years. , 2013, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

[20]  J. Serletti,et al.  Simultaneous Transfer of Free Fibula and Radial Forearm Flaps for Complex Oromandibular Reconstruction , 1998, Journal of reconstructive microsurgery.

[21]  R. Hayden,et al.  The optimum method for reconstruction of complex lateral oromandibular‐cutaneous defects , 2000, Head & neck.

[22]  E. Roumanas,et al.  Reconstructed Mandibular Defects: Fibula Free Flaps and Osseointegrated Implants , 1997, Plastic and reconstructive surgery.

[23]  Andries van der Bilt,et al.  Free vascularized flaps for reconstruction of the mandible: complications, success, and dental rehabilitation. , 2012, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[24]  K. Schepman,et al.  Rehabilitation after mandibular reconstruction with fibula free-flap: clinical outcome and quality of life assessment. , 2008, International journal of oral and maxillofacial surgery.

[25]  E. Santamaria,et al.  Primary Insertion of Osseointegrated Dental Implants into Fibula Osteoseptocutaneous Free Flap for Mandible Reconstruction , 1998, Plastic and reconstructive surgery.

[26]  James S. Brown,et al.  The influence of the pattern of mandibular invasion on recurrence and survival in oral squamous cell carcinoma , 2004, Head & neck.

[27]  M. Hanasono,et al.  Computer‐assisted design and rapid prototype modeling in microvascular mandible reconstruction , 2013, The Laryngoscope.

[28]  Peter Kessler,et al.  Additive manufacturing for microvascular reconstruction of the mandible in 20 patients. , 2012, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

[29]  Bin Zhang,et al.  Application of CAD/CAM-assisted technique with surgical treatment in reconstruction of the mandible. , 2012, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

[30]  Eben Rosenthal,et al.  Functional Outcomes of Fibula and Osteocutaneous Forearm Free Flap Reconstuction for Segmental Mandibular Defects , 2010, The Laryngoscope.

[31]  S. Yokoo,et al.  Novel classification system for oncological mandibular defect: CAT classification , 2008 .

[32]  G. Robb,et al.  Pediatric mandibular reconstruction using a vascularized fibula flap , 2008, Head & neck.

[33]  R. Ferris,et al.  Reconstruction of the Through‐and‐Through Anterior Mandibulectomy Defect: Indications and Limitations of the Double‐Skin Paddle Fibular Free Flap , 2008, The Laryngoscope.

[34]  M. Hanasono,et al.  A prospective analysis of bony versus soft-tissue reconstruction for posterior mandibular defects. , 2010, Plastic and reconstructive surgery.

[35]  E. D. Vaughan,et al.  Osteosynthetic titanium mini-plate fixation of composite radial forearm flaps in mandibular reconstruction. , 1991, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

[36]  P. Yadav,et al.  Reconstruction of oncological oro-mandibular defects with double skin paddled-free fibula flap: a prudent alternative to double flaps in resource-constrained centres. , 2012, Journal of cancer research and therapeutics.

[37]  R. Mericske-Stern,et al.  Oral rehabilitation after mandibular reconstruction using an osteocutaneous fibula free flap with endosseous implants. Factors affecting the functional outcome in patients with oral cancer. , 2004, Clinical oral implants research.

[38]  Horácio Costa,et al.  The application of 3-D biomodeling technology in complex mandibular reconstruction—experience of 47 clinical cases , 2010, European Journal of Plastic Surgery.

[39]  M. Hanasono,et al.  Free flap reconstruction of osteoradionecrosis of the mandible: A 10‐year review and defect classification , 2011, Head & neck.

[40]  A. Menderes,et al.  Surgical management of ameloblastoma in the mandible: Segmental mandibulectomy and immediate reconstruction with free fibula or deep circumflex iliac artery flap (evaluation of the long-term esthetic and functional results). , 2006, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[41]  Fu-Chan Wei,et al.  Segmental Mandibulectomy and Immediate Free Fibula Osteoseptocutaneous Flap Reconstruction with Endosteal Implants: An Ideal Treatment Method for Mandibular Ameloblastoma , 2004, Plastic and reconstructive surgery.

[42]  K. Fung,et al.  A new angle to mandibular reconstruction: The scapular tip free flap , 2013, Head & neck.

[43]  K. Fung,et al.  The scapular free flap: when versatility is needed in head and neck reconstruction. , 2010, Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale.

[44]  M. Boysen,et al.  Mandibular osteoradionecrosis: reconstructive surgery. , 2002, Clinical otolaryngology and allied sciences.

[45]  E. Ongkosuwito,et al.  Linear Mandibular Measurements: Comparison between Orthopantomograms and Lateral Cephalograms , 2009, The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association.

[46]  J. Katsaros,et al.  Mandibular Reconstruction with Vascularized Iliac Crest: A 10‐Year Experience , 1988, Plastic and reconstructive surgery.

[47]  W H Wang,et al.  Three-dimensional virtual technology in reconstruction of mandibular defect including condyle using double-barrel vascularized fibula flap. , 2013, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

[48]  Primary Insertion of Osseointegrated Dental Implants into Fibula Osteoseptocutaneous Free Flap for Mandible Reconstruction , 1998 .

[49]  D. Buchbinder,et al.  Oromandibular reconstruction using microvascular composite free flaps. Report of 71 cases and a new classification scheme for bony, soft-tissue, and neurologic defects. , 1991, Archives of otolaryngology--head & neck surgery.

[50]  Wei Huang,et al.  Using computer simulation and stereomodel for accurate mandibular reconstruction with vascularized iliac crest flap. , 2012, Oral surgery, oral medicine, oral pathology and oral radiology.

[51]  P. Gullane,et al.  The free iliac crest and fibula flaps in vascularized oromandibular reconstruction: Comparison and long‐term evaluation , 1999, Head & neck.

[52]  Daniel Buchbinder,et al.  Functional evaluation following microvascular oromandibular reconstruction of the oral cancer patient: A comparative study of reconstructed and nonreconstructed patients , 1991, The Laryngoscope.

[53]  J. Carrillo,et al.  Oromandibular Reconstruction for Oncological Purposes , 2000, Annals of plastic surgery.

[54]  P. Gullane,et al.  Classification of Mandibular Defects , 1993, Plastic and reconstructive surgery.

[55]  Wei-Chao Huang,et al.  Mandible reconstruction using the calcium-sulphate three-dimensional model and rubber stick: a new method, 'mould technique', for more accurate, efficient and simplified fabrication. , 2011, Journal of plastic, reconstructive & aesthetic surgery : JPRAS.

[56]  N. Weinzweig,et al.  Oromandibular Reconstruction Using a Keel‐shaped Modification of the Radial Forearm Osteocutaneous Flap , 1994, Annals of plastic surgery.

[57]  T. Gal,et al.  Reconstruction of the through-and-through oral cavity defect with the fibula free flap , 2009, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[58]  D. Buchbinder,et al.  The combined sensate radial forearm and iliac crest free flaps for reconstruction of significant glossectomy‐mandibulectomy defects , 1992, The Laryngoscope.

[59]  J. P. Watson,et al.  Reconstruction of Composite Through-and-Through Mandibular Defects with a Double-Skin Paddle Fibular Osteocutaneous Flap , 2003, Plastic and reconstructive surgery.

[60]  M. Kusama,et al.  Bare bone graft with vascularised iliac crest for mandibular reconstruction. , 2012, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

[61]  J Mercier,et al.  Advantages and limitations of the fibula free flap in mandibular reconstruction. , 1997, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[62]  F. Wei,et al.  Fibula Osteoseptocutaneous Flap for Reconstruction of Composite Mandibular Defects , 1994, Plastic and reconstructive surgery.

[63]  J. H. Lee,et al.  Mandibular reconstruction with free vascularized fibular flap. , 1995, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

[64]  S. Rogers,et al.  Salvage outcomes of free tissue transfer in Liverpool: trends over 18 years (1992-2009). , 2012, The British journal of oral & maxillofacial surgery.

[65]  M. Urken Composite free flaps in oromandibular reconstruction. Review of the literature. , 1991, Archives of otolaryngology--head & neck surgery.

[66]  Alberto Bianchi,et al.  Oromandibular Reconstruction Using a Fibula Osteocutaneous Free Flap: Four Different “Preplating” Techniques , 2006, Plastic and reconstructive surgery.