The Lipid Kinase PIP5K1C Regulates Pain Signaling and Sensitization

[1]  H. Sakagami,et al.  Type I phosphatidylinositol 4‐phosphate 5‐kinase γ is required for neuronal migration in the mouse developing cerebral cortex , 2013, The European journal of neuroscience.

[2]  Damian Smedley,et al.  Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes , 2013, Cell.

[3]  P. Anand,et al.  Analgesic efficacy and safety of the novel p38 MAP kinase inhibitor, losmapimod, in patients with neuropathic pain following peripheral nerve injury: a double‐blind, placebo‐controlled study , 2013, European journal of pain.

[4]  M. Zylka,et al.  Peptidergic CGRPα Primary Sensory Neurons Encode Heat and Itch and Tonically Suppress Sensitivity to Cold , 2013, Neuron.

[5]  M. Cousins,et al.  The safety and efficacy of KAI-1678- an inhibitor of epsilon protein kinase C (εPKC)-versus lidocaine and placebo for the treatment of postherpetic neuralgia: a crossover study design. , 2013, Pain medicine.

[6]  R. Fässler,et al.  Comparative phenotypic analysis of the two major splice isoforms of phosphatidylinositol phosphate kinase type I&ggr; in vivo , 2012, Journal of Cell Science.

[7]  Yasunori Kanaho,et al.  Construction of a Global Pain Systems Network Highlights Phospholipid Signaling as a Regulator of Heat Nociception , 2012, PLoS genetics.

[8]  D. Mohapatra,et al.  The C-Type Natriuretic Peptide Induces Thermal Hyperalgesia through a Noncanonical Gβγ-dependent Modulation of TRPV1 Channel , 2012, The Journal of Neuroscience.

[9]  M. Bortolozzi,et al.  Reduced phosphatidylinositol 4,5-bisphosphate synthesis impairs inner ear Ca2+ signaling and high-frequency hearing acquisition , 2012, Proceedings of the National Academy of Sciences.

[10]  L. Hunyady,et al.  Acute depletion of plasma membrane phosphatidylinositol 4,5-bisphosphate impairs specific steps in endocytosis of the G-protein-coupled receptor , 2012, Journal of Cell Science.

[11]  L. Hunyady,et al.  Acute depletion of plasma membrane phosphatidylinositol 4,5-bisphosphate impairs specific steps in endocytosis of the G-protein-coupled receptor , 2012, Journal of Cell Science.

[12]  S. Daniels,et al.  Novel p38α Mitogen‐Activated Protein Kinase Inhibitor Shows Analgesic Efficacy in Acute Postsurgical Dental Pain , 2012, Journal of clinical pharmacology.

[13]  C. Stucky,et al.  TRPC1 contributes to light-touch sensation and mechanical responses in low-threshold cutaneous sensory neurons. , 2012, Journal of neurophysiology.

[14]  M. Yuzaki,et al.  NMDA Receptor-Mediated PIP5K Activation to Produce PI(4,5)P2 Is Essential for AMPA Receptor Endocytosis during LTD , 2012, Neuron.

[15]  A. Todd,et al.  Gαq/11 signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization , 2012, PAIN.

[16]  P. Anand,et al.  Clinical trial of the p38 MAP kinase inhibitor dilmapimod in neuropathic pain following nerve injury , 2011, European journal of pain.

[17]  O. Andersen,et al.  Phosphoinositides alter lipid bilayer properties , 2011, The Journal of general physiology.

[18]  M. Hung,et al.  EZH2 Regulates Neuronal Differentiation of Mesenchymal Stem Cells through PIP5K1C-dependent Calcium Signaling* , 2011, The Journal of Biological Chemistry.

[19]  R. Wightman,et al.  PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine , 2011, Molecular pain.

[20]  M. Gold,et al.  Nociceptor sensitization in pain pathogenesis , 2010, Nature Medicine.

[21]  P. Kubes,et al.  Integrin-induced PIP5K1C kinase polarization regulates neutrophil polarization, directionality, and in vivo infiltration. , 2010, Immunity.

[22]  B. Hille,et al.  SYMPOSIUM REVIEW: Phosphoinositides: lipid regulators of membrane proteins , 2010, The Journal of physiology.

[23]  P. De Camilli,et al.  Phosphatidylinositol-4-Phosphate 5-Kinases and Phosphatidylinositol 4,5-Bisphosphate Synthesis in the Brain , 2010, The Journal of Biological Chemistry.

[24]  Iman van den Bout,et al.  PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions , 2009, Journal of Cell Science.

[25]  David Julius,et al.  Cellular and Molecular Mechanisms of Pain , 2009, Cell.

[26]  P. De Camilli,et al.  The β- and γ-isoforms of type I PIP5K regulate distinct stages of Ca2+ signaling in mast cells , 2009, Journal of Cell Science.

[27]  Misaki Matsumoto,et al.  Evidence for lysophosphatidic acid 1 receptor signaling in the early phase of neuropathic pain mechanisms in experiments using Ki‐16425, a lysophosphatidic acid 1 receptor antagonist , 2009, Journal of neurochemistry.

[28]  R. Ji,et al.  MAP kinase and pain , 2009, Brain Research Reviews.

[29]  M. Zylka,et al.  Prostatic Acid Phosphatase Is an Ectonucleotidase and Suppresses Pain by Generating Adenosine , 2008, Neuron.

[30]  T. Rohacs,et al.  Phospholipase C Mediated Modulation of TRPV1 Channels , 2008, Molecular Neurobiology.

[31]  R. Ji,et al.  Intracellular Signaling in Primary Sensory Neurons and Persistent Pain , 2008, Neurochemical Research.

[32]  Mark S. Shapiro,et al.  Regulation of ion transport proteins by membrane phosphoinositides , 2007, Nature Reviews Neuroscience.

[33]  William A Weiss,et al.  Recognizing and exploiting differences between RNAi and small-molecule inhibitors. , 2007, Nature chemical biology.

[34]  G. Narkis,et al.  Lethal contractural syndrome type 3 (LCCS3) is caused by a mutation in PIP5K1C, which encodes PIPKI gamma of the phophatidylinsitol pathway. , 2007, American journal of human genetics.

[35]  J. Golden,et al.  PIP5KIγ is required for cardiovascular and neuronal development , 2007, Proceedings of the National Academy of Sciences.

[36]  P. Várnai,et al.  Dual Regulation of TRPV1 by Phosphoinositides , 2007, The Journal of Neuroscience.

[37]  J. Calixto,et al.  Intraplantar PGE2 causes nociceptive behaviour and mechanical allodynia: the role of prostanoid E receptors and protein kinases , 2007, British journal of pharmacology.

[38]  J. Levine,et al.  Epac Mediates a cAMP-to-PKC Signaling in Inflammatory Pain: An Isolectin B4(+) Neuron-Specific Mechanism , 2005, The Journal of Neuroscience.

[39]  F. Porreca,et al.  An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons , 2005, Molecular pain.

[40]  Wen Hong Li,et al.  Critical role of PIP5KIγ87 in InsP3-mediated Ca2+ signaling , 2004, The Journal of cell biology.

[41]  V. Chapman,et al.  Evidence for biological effects of exogenous LPA on rat primary afferent and spinal cord neurons , 2004, Brain Research.

[42]  R. Fitzsimonds,et al.  Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking , 2004, Nature.

[43]  A. Basbaum,et al.  Spared nerve injury model of neuropathic pain in the mouse: a behavioral and anatomic analysis. , 2003, The journal of pain : official journal of the American Pain Society.

[44]  C. Fairbanks Spinal delivery of analgesics in experimental models of pain and analgesia. , 2003, Advanced drug delivery reviews.

[45]  David J. Anderson,et al.  Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[46]  K. Ling,et al.  Type Iγ phosphatidylinositol phosphate kinase targets and regulates focal adhesions , 2002, Nature.

[47]  C. Woolf,et al.  p38 MAPK Activation by NGF in Primary Sensory Neurons after Inflammation Increases TRPV1 Levels and Maintains Heat Hyperalgesia , 2002, Neuron.

[48]  Yi Dai,et al.  Phosphorylation of Extracellular Signal-Regulated Kinase in Primary Afferent Neurons by Noxious Stimuli and Its Involvement in Peripheral Sensitization , 2002, The Journal of Neuroscience.

[49]  P. Camilli,et al.  PIP Kinase Iγ Is the Major PI(4,5)P2 Synthesizing Enzyme at the Synapse , 2001, Neuron.

[50]  J. Levine,et al.  Nociceptor Sensitization by Extracellular Signal-Regulated Kinases , 2001, The Journal of Neuroscience.

[51]  J. Levine,et al.  Chronic Hypersensitivity For Inflammatory Nociceptor Sensitization Mediated by the ε Isozyme of Protein Kinase C , 2000, The Journal of Neuroscience.

[52]  H. Ueda,et al.  Vzg-1/lysophosphatidic acid-receptor involved in peripheral pain transmission. , 2000, Brain research. Molecular brain research.

[53]  H. Ueda,et al.  Lysophosphatidic acid-induced, pertussis toxin-sensitive nociception through a substance P release from peripheral nerve endings in mice , 1999, Neuroscience Letters.

[54]  L. Dekker,et al.  Specific Involvement of PKC-ε in Sensitization of the Neuronal Response to Painful Heat , 1999, Neuron.

[55]  D. Linseman,et al.  A role for a wortmannin-sensitive phosphatidylinositol-4-kinase in the endocytosis of muscarinic cholinergic receptors. , 1998, Molecular pharmacology.

[56]  Y. Yazaki,et al.  Type I Phosphatidylinositol-4-phosphate 5-Kinases , 1998, The Journal of Biological Chemistry.

[57]  D. Simone,et al.  Enhanced withdrawal responses to heat and mechanical stimuli following intraplantar injection of capsaicin in rats , 1996, PAIN.

[58]  O. Hayaishi,et al.  Characterization of EP‐receptor subtypes involved in allodynia and hyperalgesia induced by intrathecal administration of prostaglandin E2 to mice , 1994, British journal of pharmacology.

[59]  J. Fozard,et al.  Age changes in pure-tone hearing thresholds in a longitudinal study of normal human aging. , 1990, The Journal of the Acoustical Society of America.

[60]  E. Ruelland,et al.  Signal transduction pathways involving phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: convergences and divergences among eukaryotic kingdoms. , 2013, Progress in lipid research.

[61]  Mindy I. Davis,et al.  A quantitative analysis of kinase inhibitor selectivity , 2008, Nature Biotechnology.

[62]  J. Golden,et al.  PIP5KI gamma is required for cardiovascular and neuronal development. , 2007, Proceedings of the National Academy of Sciences of the United States of America.

[63]  H. Sakagami,et al.  Localization of mRNAs for phosphatidylinositol phosphate kinases in the mouse brain during development. , 2002, Brain research. Gene expression patterns.

[64]  K. Ling,et al.  Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions. , 2002, Nature.

[65]  P. De Camilli,et al.  PIP kinase Igamma is the major PI(4,5)P(2) synthesizing enzyme at the synapse. , 2001, Neuron.

[66]  J. Levine,et al.  Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C. , 2000, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[67]  L. Dekker,et al.  Specific involvement of PKC-epsilon in sensitization of the neuronal response to painful heat. , 1999, Neuron.

[68]  Y. Yazaki,et al.  Ishihara, H. et al. Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family. J. Biol. Chem. 273, 8741-8748 , 1998 .

[69]  R. Evans,et al.  Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling , 2022 .