Large cell calcifying Sertoli cell tumour: molecular and immunohistochemical assessment of a series comprising non‐metastasising and metastasising neoplasms

Large cell calcifying Sertoli cell tumour (LCCSCT) is a type of testicular sex cord‐stromal tumour that may occur sporadically or in the context of Carney complex and other genetic syndromes. A subset is clinically malignant, and the molecular mechanisms that drive such aggressive behaviour remain unknown.

[1]  Danielle K. Manning,et al.  Deriving tumor purity from cancer next generation sequencing data: applications for quantitative ERBB2 (HER2) copy number analysis and germline inference of BRCA1 and BRCA2 mutations , 2022, Modern Pathology.

[2]  J. Cheville,et al.  Large cell calcifying Sertoli cell tumour: a contemporary multi‐institutional case series highlighting the diagnostic utility of PRKAR1A immunohistochemistry , 2021, Histopathology.

[3]  F. Faucz,et al.  Somatic PRKAR1A Gene Mutation in a Nonsyndromic Metastatic Large Cell Calcifying Sertoli Cell Tumor , 2019, Journal of the Endocrine Society.

[4]  L. Macconaill,et al.  Targeted Cancer Next-Generation Sequencing as a Primary Screening Tool for Microsatellite Instability and Lynch Syndrome in Upper Gastrointestinal Tract Cancers , 2019, Cancer Epidemiology, Biomarkers & Prevention.

[5]  L. Macconaill,et al.  Validation of a targeted next-generation sequencing approach to detect mismatch repair deficiency in colorectal adenocarcinoma , 2018, Modern Pathology.

[6]  L. Macconaill,et al.  Validation of OncoPanel: A Targeted Next-Generation Sequencing Assay for the Detection of Somatic Variants in Cancer. , 2017, Archives of pathology & laboratory medicine.

[7]  Marian Harris,et al.  Institutional implementation of clinical tumor profiling on an unselected cancer population. , 2016, JCI insight.

[8]  W. Hahn,et al.  BreaKmer: detection of structural variation in targeted massively parallel sequencing data using kmers , 2014, Nucleic acids research.

[9]  O. Hes,et al.  Large cell calcifying Sertoli cell tumor: a clinicopathologic study of 1 malignant and 3 benign tumors using histomorphology, immunohistochemistry, ultrastructure, comparative genomic hybridization, and polymerase chain reaction analysis of the PRKAR1A gene. , 2010, Human pathology.

[10]  G. MacLennan,et al.  Large cell calcifying Sertoli cell tumor of testis. , 2007, The Journal of urology.

[11]  M. Amin,et al.  Intratubular Large Cell Hyalinizing Sertoli Cell Neoplasia of the Testis: A Report of 8 Cases of a Distinctive Lesion of the Peutz-Jeghers Syndrome , 2007, The American journal of surgical pathology.

[12]  J. Bertherat,et al.  Protein kinase-A activity in PRKAR1A-mutant cells, and regulation of mitogen-activated protein kinases ERK1/2. , 2003, Human molecular genetics.

[13]  C. Stratakis.  Mutations of the Gene Encoding the Protein Kinase A Type I‐α Regulatory Subunit (PRKAR1A) in Patients with the “Complex of Spotty Skin Pigmentation, Myxomas, Endocrine Overactivity, and Schwannomas” (Carney Complex) , 2002, Annals of the New York Academy of Sciences.

[14]  J. Srigley,et al.  Large cell calcifying Sertoli cell tumor of the testis: contrasting features of six malignant and six benign tumors and a review of the literature. , 1997, The American journal of surgical pathology.

[15]  H. Manzanilla-García,et al.  Large-cell calcifying Sertoli cell tumor , 2005 .