Triple-Modal Imaging-Guided Chemo-Photothermal Synergistic Therapy for Breast Cancer with Magnetically Targeted Phase-Shifted Nanoparticles.

Current nanodrug-based cancer therapy is susceptible to the problems of rapid clearance from circulation and limited therapeutic efficacy. Herein, we report a magnetically targeted and photothermal-triggered drug release nanotheranostics system based on superparamagnetic iron oxide (Fe3O4), IR780, doxorubicin (DOX), and perfluoropentane (PFP) entrapped poly-lactide- co-glycolide (PLGA) nanoparticles (IR780/Fe3O4@PLGA/PFP/DOX NPs) for triple-modal imaging-guided synergistic therapy of breast cancer. In this work, IR780 and Fe3O4 convert light into heat, which triggers DOX release from IR780/Fe3O4@PLGA/PFP/DOX NPs and a phase-shift thermoelastic expansion of PFP; this procedure further accelerates the DOX release and tissue extrusion deformation. Fe3O4 NPs also serve as the target moiety by an external magnet directed to the tumor. Specifically, the IR780/Fe3O4@PLGA/PFP/DOX NPs can be used for triple-modal imaging, including near infrared fluorescence, magnetic resonance, and ultrasound. Furthermore, the antitumor therapy studies reveal the extraordinary performance of IR780/Fe3O4@PLGA/PFP/DOX NPs in magnetically targeted synergistic chemo-photothermal therapy of cancer. Therefore, the multifunctional IR780/Fe3O4@PLGA/PFP/DOX NPs guided by the magnetic field show a great potential for cancer theranostics.

[1]  Jun Zhang,et al.  Black Phosphorus Quantum Dots Gated, Carbon-Coated Fe3 O4 Nanocapsules (BPQDs@ss-Fe3 O4 @C) with Low Premature Release Could Enable Imaging-Guided Cancer Combination Therapy. , 2018, Chemistry.

[2]  Jianxiu Wang,et al.  Triple Stimuli-Responsive Magnetic Hollow Porous Carbon-Based Nanodrug Delivery System for Magnetic Resonance Imaging-Guided Synergistic Photothermal/Chemotherapy of Cancer. , 2018, ACS applied materials & interfaces.

[3]  Zhigang Wang,et al.  Perfluorooctyl bromide & indocyanine green co-loaded nanoliposomes for enhanced multimodal imaging-guided phototherapy. , 2018, Biomaterials.

[4]  P. Kulkarni,et al.  Polymeric micelles: Theranostic co-delivery system for poorly water-soluble drugs and contrast agents. , 2018, Biomaterials.

[5]  Ke Yang,et al.  Bioinspired Multifunctional Melanin-Based Nanoliposome for Photoacoustic/Magnetic Resonance Imaging-Guided Efficient Photothermal Ablation of Cancer , 2018, Theranostics.

[6]  Zhigang Wang,et al.  Drug Release from Phase-Changeable Nanodroplets Triggered by Low-Intensity Focused Ultrasound , 2018, Theranostics.

[7]  Kui Tang,et al.  Phase-shifted paclitaxel-loaded multifunctional contrast agent for US/MR imaging and synergistic hyperthermal/chemotherapy of metastasis in lymph nodes , 2018, RSC advances.

[8]  Peijun Wang,et al.  Enhanced Synergism of Thermo-chemotherapy For Liver Cancer with Magnetothermally Responsive Nanocarriers , 2018, Theranostics.

[9]  Chengcheng Niu,et al.  Thermal-sensitive magnetic nanoparticles for dual-modal tumor imaging and therapy , 2017 .

[10]  Near-infrared induced phase-shifted ICG/Fe3O4 loaded PLGA nanoparticles for photothermal tumor ablation , 2017, Scientific Reports.

[11]  Xiaoyuan Chen,et al.  Rethinking cancer nanotheranostics. , 2017, Nature reviews. Materials.

[12]  Peng Huang,et al.  Tri-stimuli-responsive biodegradable theranostics for mild hyperthermia enhanced chemotherapy. , 2017, Biomaterials.

[13]  Ru Cheng,et al.  Robust, Responsive, and Targeted PLGA Anticancer Nanomedicines by Combination of Reductively Cleavable Surfactant and Covalent Hyaluronic Acid Coating. , 2017, ACS applied materials & interfaces.

[14]  Ligeng Xu,et al.  Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy , 2016, Nature Communications.

[15]  Yihe Hu,et al.  Indocyanine-green-loaded microbubbles for localization of sentinel lymph node using near-infrared fluorescence/ultrasound imaging: a feasibility study , 2016 .

[16]  J. Ji,et al.  IR-780 Loaded Phospholipid Mimicking Homopolymeric Micelles for Near-IR Imaging and Photothermal Therapy of Pancreatic Cancer. , 2016, ACS applied materials & interfaces.

[17]  Fei Yan,et al.  Molecular imaging-guided photothermal/photodynamic therapy against tumor by iRGD-modified indocyanine green nanoparticles. , 2016, Journal of controlled release : official journal of the Controlled Release Society.

[18]  Andrea Protti,et al.  Triple-Modal Imaging of Magnetically-Targeted Nanocapsules in Solid Tumours In Vivo , 2016, Theranostics.

[19]  Kangqiang Qiu,et al.  Noncovalent Ruthenium(II) Complexes-Single-Walled Carbon Nanotube Composites for Bimodal Photothermal and Photodynamic Therapy with Near-Infrared Irradiation. , 2015, ACS applied materials & interfaces.

[20]  Jinping Wang,et al.  Smart IR780 Theranostic Nanocarrier for Tumor-Specific Therapy: Hyperthermia-Mediated Bubble-Generating and Folate-Targeted Liposomes. , 2015, ACS applied materials & interfaces.

[21]  Junqing Hu,et al.  Gold nanorods as a theranostic platform for in vitro and in vivo imaging and photothermal therapy of inflammatory macrophages. , 2015, Nanoscale.

[22]  Zhigang Wang,et al.  Phase-Shifted PFH@PLGA/Fe3O4 Nanocapsules for MRI/US Imaging and Photothermal Therapy with near-Infrared Irradiation. , 2015, ACS applied materials & interfaces.

[23]  Jie Yu,et al.  Smart MoS2/Fe3O4 Nanotheranostic for Magnetically Targeted Photothermal Therapy Guided by Magnetic Resonance/Photoacoustic Imaging , 2015, Theranostics.

[24]  Wei Liu,et al.  Self-assembled PEG-IR-780-C13 micelle as a targeting, safe and highly-effective photothermal agent for in vivo imaging and cancer therapy. , 2015, Biomaterials.

[25]  Hao Cheng,et al.  Hydrophobic IR780 encapsulated in biodegradable human serum albumin nanoparticles for photothermal and photodynamic therapy. , 2015, Acta biomaterialia.

[26]  Yuhua Cao,et al.  Manganese doped iron oxide theranostic nanoparticles for combined T1 magnetic resonance imaging and photothermal therapy. , 2015, ACS applied materials & interfaces.

[27]  Michael C. Kolios,et al.  Laser‐Activatible PLGA Microparticles for Image‐Guided Cancer Therapy In Vivo , 2014, Advanced Functional Materials.

[28]  Ligeng Xu,et al.  Immunological Responses Triggered by Photothermal Therapy with Carbon Nanotubes in Combination with Anti‐CTLA‐4 Therapy to Inhibit Cancer Metastasis , 2014, Advanced materials.

[29]  Feng Gao,et al.  Erythrocyte membrane is an alternative coating to polyethylene glycol for prolonging the circulation lifetime of gold nanocages for photothermal therapy. , 2014, ACS nano.

[30]  Wei Wang,et al.  Iron/iron oxide core/shell nanoparticles for magnetic targeting MRI and near-infrared photothermal therapy. , 2014, Biomaterials.

[31]  Lintao Cai,et al.  Improving drug accumulation and photothermal efficacy in tumor depending on size of ICG loaded lipid-polymer nanoparticles. , 2014, Biomaterials.

[32]  Z. Qian,et al.  Mesoporous Magnetic Gold “Nanoclusters” as Theranostic Carrier for Chemo-Photothermal Co-therapy of Breast Cancer , 2014, Theranostics.

[33]  Gang Bao,et al.  Gold Nanoshelled Liquid Perfluorocarbon Magnetic Nanocapsules: a Nanotheranostic Platform for Bimodal Ultrasound/Magnetic Resonance Imaging Guided Photothermal Tumor Ablation , 2013, Theranostics.

[34]  Peng Liu,et al.  IR-780 dye loaded tumor targeting theranostic nanoparticles for NIR imaging and photothermal therapy. , 2013, Biomaterials.

[35]  Weixiang Song,et al.  Doxorubicin loaded superparamagnetic PLGA-iron oxide multifunctional microbubbles for dual-mode US/MR imaging and therapy of metastasis in lymph nodes. , 2013, Biomaterials.

[36]  Xin Cai,et al.  Comparison study of gold nanohexapods, nanorods, and nanocages for photothermal cancer treatment. , 2013, ACS nano.

[37]  Wei R. Chen,et al.  Antitumor immunologically modified carbon nanotubes for photothermal therapy. , 2012, Biomaterials.

[38]  Chih-Kuang Yeh,et al.  Aptamer-conjugated and drug-loaded acoustic droplets for ultrasound theranosis. , 2012, Biomaterials.

[39]  Chih-Kuang Yeh,et al.  Intracellular acoustic droplet vaporization in a single peritoneal macrophage for drug delivery applications. , 2011, Langmuir : the ACS journal of surfaces and colloids.

[40]  Zhong-gao Gao,et al.  Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy. , 2007, Journal of the National Cancer Institute.