Treatment of liver metastases from colorectal cancer with hepatic artery occlusion, intraportal 5‐fluorouracil infusion, and oral allopurinol. A randomized clinical trial

Background. Regional therapy for colorectal liver metastases aimed at prolonging survival has not been tested fully in a randomized trial with untreated control subjects. This study explored the efficacy of temporary hepatic artery occlusion followed by intraportal infusion of 5‐fluorouracil(5‐FU) and oral allopurinol as biochemical modulators in prolonging the survival of patients with nonresectable liver metastases and no extrahepatic cancer.

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