Neural circuitry underlying effects of context on human pain‐related fear extinction in a renewal paradigm

The role of context in pain‐related extinction learning remains poorly understood. We analyzed the neural mechanisms underlying context‐dependent extinction and renewal in a clinically relevant model of conditioned abdominal pain‐related fear.

[1]  M. Popovic,et al.  Strain wars 3: Differences in infectivity and pathogenicity between Delta and Omicron strains of SARS-CoV-2 can be explained by thermodynamic and kinetic parameters of binding and growth , 2022, Microbial Risk Analysis.

[2]  Steven De Peuter,et al.  The Reduction of Fear of Movement-related Pain: Does Motivational Context Matter? , 2015, The Clinical journal of pain.

[3]  M. Forsting,et al.  Neural circuitry of abdominal pain‐related fear learning and reinstatement in irritable bowel syndrome , 2015, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[4]  J. Vlaeyen,et al.  Differences in pain-related fear acquisition and generalization: an experimental study comparing patients with fibromyalgia and healthy controls , 2015, Pain.

[5]  M. Forsting,et al.  Learning pain-related fear: Neural mechanisms mediating rapid differential conditioning, extinction and reinstatement processes in human visceral pain , 2014, Neurobiology of Learning and Memory.

[6]  E. Navratilova,et al.  Reward and motivation in pain and pain relief , 2014, Nature Neuroscience.

[7]  M. Meulders,et al.  Positive affect protects against deficient safety learning during extinction of fear of movement-related pain in healthy individuals scoring relatively high on trait anxiety. , 2014, Journal of Pain.

[8]  Fabrizio Benedetti,et al.  Pain and the context , 2014, Nature Reviews Rheumatology.

[9]  M. Forsting,et al.  Placebo analgesia in patients with functional and organic abdominal pain: a fMRI study in IBS, UC and healthy volunteers , 2014, Gut.

[10]  J. Houtveen,et al.  Biological and psychological predictors of visceral pain sensitivity in healthy premenopausal women , 2014, European journal of pain.

[11]  B. Ljótsson,et al.  Provoking symptoms to relieve symptoms: a randomized controlled dismantling study of exposure therapy in irritable bowel syndrome. , 2014, Behaviour research and therapy.

[12]  M. Forsting,et al.  Towards understanding sex differences in visceral pain: Enhanced reactivation of classically-conditioned fear in healthy women , 2014, Neurobiology of Learning and Memory.

[13]  M. Forsting,et al.  Visceral sensitivity correlates with decreased regional gray matter volume in healthy volunteers: A voxel-based morphometry study , 2014, PAIN®.

[14]  Ralph R. Miller,et al.  Classical conditioning and pain: conditioned analgesia and hyperalgesia. , 2014, Acta psychologica.

[15]  C. S. Hubbard,et al.  Impaired emotional learning and involvement of the corticotropin-releasing factor signaling system in patients with irritable bowel syndrome. , 2013, Gastroenterology.

[16]  K. Luan Phan,et al.  The contextual brain: implications for fear conditioning, extinction and psychopathology , 2013, Nature Reviews Neuroscience.

[17]  S. Maderwald,et al.  Fear Conditioning in an Abdominal Pain Model: Neural Responses during Associative Learning and Extinction in Healthy Subjects , 2013, PloS one.

[18]  J. Vlaeyen,et al.  The acquisition and generalization of cued and contextual pain-related fear: An experimental study using a voluntary movement paradigm , 2013, PAIN.

[19]  O. Bergh,et al.  Learning to fear obstructed breathing: Comparing interoceptive and exteroceptive cues , 2013, Biological Psychology.

[20]  Bram Vervliet,et al.  Extinction, generalization, and return of fear: A critical review of renewal research in humans , 2013, Biological Psychology.

[21]  Alison R Preston,et al.  Distributed hippocampal patterns that discriminate reward context are associated with enhanced associative binding. , 2013, Journal of experimental psychology. General.

[22]  J. Mogil,et al.  Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon , 2012, Nature Reviews Neuroscience.

[23]  M. Ingvar,et al.  Distinct Contributions of the Dorsolateral Prefrontal and Orbitofrontal Cortex during Emotion Regulation , 2012, PloS one.

[24]  Steven De Peuter,et al.  Safety behavior can hamper the extinction of fear of movement-related pain: an experimental investigation in healthy participants. , 2012, Behaviour research and therapy.

[25]  Linnaea E. Ostroff,et al.  Inhibition of Fear by Learned Safety Signals: A Mini-Symposium Review , 2012, The Journal of Neuroscience.

[26]  S. Elsenbruch,et al.  How positive and negative expectations shape the experience of visceral pain: an experimental pilot study in healthy women , 2012, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[27]  A. Masclee,et al.  Irritable bowel syndrome: methods, mechanisms, and pathophysiology. Methods to assess visceral hypersensitivity in irritable bowel syndrome. , 2012, American journal of physiology. Gastrointestinal and liver physiology.

[28]  J. Vlaeyen,et al.  Reduction of fear of movement-related pain and pain-related anxiety: An associative learning approach using a voluntary movement paradigm , 2012, PAIN.

[29]  D. Shohamy,et al.  Ventromedial prefrontal-subcortical systems and the generation of affective meaning , 2012, Trends in Cognitive Sciences.

[30]  G. Ben-Shakhar,et al.  Publication recommendations for electrodermal measurements. , 1981, Psychophysiology.

[31]  G. Quirk,et al.  Fear extinction as a model for translational neuroscience: ten years of progress. , 2012, Annual review of psychology.

[32]  G. Andersson,et al.  Acceptability, effectiveness, and cost-effectiveness of internet-based exposure treatment for irritable bowel syndrome in a clinical sample: a randomized controlled trial , 2011, BMC gastroenterology.

[33]  Steven De Peuter,et al.  Understanding fear of pain in chronic pain: interoceptive fear conditioning as a novel approach. , 2011, European journal of pain.

[34]  Jan Schweckendiek,et al.  Influence of contingency awareness on neural, electrodermal and evaluative responses during fear conditioning. , 2011, Social cognitive and affective neuroscience.

[35]  S. Rauch,et al.  Altered Processing of Contextual Information during Fear Extinction in PTSD: An fMRI Study , 2011, CNS neuroscience & therapeutics.

[36]  Jennifer Labus,et al.  A cognitive-behavioral treatment for irritable bowel syndrome using interoceptive exposure to visceral sensations. , 2011, Behaviour research and therapy.

[37]  T. Egner,et al.  Emotional processing in anterior cingulate and medial prefrontal cortex , 2011, Trends in Cognitive Sciences.

[38]  J. Vlaeyen,et al.  Fear reduction in patients with chronic pain: a learning theory perspective , 2010, Expert review of neurotherapeutics.

[39]  M. Forsting,et al.  Patients with irritable bowel syndrome have altered emotional modulation of neural responses to visceral stimuli. , 2010, Gastroenterology.

[40]  B. Dahme,et al.  Unconditioned and conditioned muscular responses in patients with chronic back pain and chronic tension-type headaches and in healthy controls , 2010, PAIN.

[41]  Mauricio R. Delgado,et al.  Overlapping neural systems mediating extinction, reversal and regulation of fear , 2010, Trends in Cognitive Sciences.

[42]  H. Rüddel,et al.  Alteration of Delay and Trace Eyeblink Conditioning in Fibromyalgia Patients , 2010, Psychosomatic medicine.

[43]  Johannes J. Letzkus,et al.  Neuronal circuits of fear extinction , 2010, The European journal of neuroscience.

[44]  T. Egner,et al.  A translational bridge between mouse and human models of learned safety , 2010, Annals of medicine.

[45]  J. Katz,et al.  Understanding the co‐occurrence of anxiety disorders and chronic pain: state‐of‐the‐art , 2009, Depression and anxiety.

[46]  S. Orr,et al.  An alternative scoring method for skin conductance responding in a differential fear conditioning paradigm with a long-duration conditioned stimulus. , 2009, Psychophysiology.

[47]  A novel approach to background reduction in double beta decay experiments , 2009, 0908.0164.

[48]  V. Arolt,et al.  Human Fear Conditioning and Extinction in Neuroimaging: A Systematic Review , 2009, PloS one.

[49]  H. Flor,et al.  Context conditioning and extinction in humans: differential contribution of the hippocampus, amygdala and prefrontal cortex , 2009, The European journal of neuroscience.

[50]  M. Forsting,et al.  Affective disturbances modulate the neural processing of visceral pain stimuli in irritable bowel syndrome: an fMRI study , 2009, Gut.

[51]  Gang Chen,et al.  Contextual Fear Conditioning in Humans: Cortical-Hippocampal and Amygdala Contributions , 2008, The Journal of Neuroscience.

[52]  Yuchiao Chang,et al.  Presence and acquired origin of reduced recall for fear extinction in PTSD: results of a twin study. , 2008, Journal of psychiatric research.

[53]  G. Quirk,et al.  Neural Mechanisms of Extinction Learning and Retrieval , 2008, Neuropsychopharmacology.

[54]  黒崎明子,et al.  同種造血幹細胞移植を受けた患者の不安および抑うつに関してHospital Anxiety and Depression Scale(HADS)を用いた経時的観察 , 2008 .

[55]  B. Spiegel,et al.  Functional GI disorders: from animal models to drug development , 2007, Gut.

[56]  S. Rauch,et al.  Recall of Fear Extinction in Humans Activates the Ventromedial Prefrontal Cortex and Hippocampus in Concert , 2007, Biological Psychiatry.

[57]  M. Kindt,et al.  Contextual control of human fear associations in a renewal paradigm. , 2007, Behaviour research and therapy.

[58]  P. Enck,et al.  Role of classical conditioning in learning gastrointestinal symptoms. , 2007, World journal of gastroenterology.

[59]  J. Rhudy,et al.  The influence of conditioned fear on human pain thresholds: does preparedness play a role? , 2007, The journal of pain : official journal of the American Pain Society.

[60]  Nikolaus Weiskopf,et al.  Context-Dependent Human Extinction Memory Is Mediated by a Ventromedial Prefrontal and Hippocampal Network , 2006, The Journal of Neuroscience.

[61]  D. Norris,et al.  BOLD contrast sensitivity enhancement and artifact reduction with multiecho EPI: Parallel‐acquired inhomogeneity‐desensitized fMRI , 2006, Magnetic resonance in medicine.

[62]  G. Barker,et al.  Study design in fMRI: Basic principles , 2006, Brain and Cognition.

[63]  Kevin N. Ochsner,et al.  Neural correlates of individual differences in pain-related fear and anxiety , 2006, Pain.

[64]  P. Onghena,et al.  Reduction of pain-related fear in complex regional pain syndrome type I: The application of graded exposure in vivo , 2005, Pain.

[65]  S. Rauch,et al.  Context modulation of memory for fear extinction in humans. , 2005, Psychophysiology.

[66]  Qasim Aziz,et al.  Brain response to visceral aversive conditioning: a functional magnetic resonance imaging study. , 2005, Gastroenterology.

[67]  E. Phelps,et al.  Reinstatement of conditioned fear in humans is context dependent and impaired in amnesia. , 2005, Behavioral neuroscience.

[68]  J. Gross,et al.  The cognitive control of emotion , 2005, Trends in Cognitive Sciences.

[69]  T. Beckers,et al.  Return of fear in a human differential conditioning paradigm caused by a return to the original acquistion context. , 2005, Behaviour research and therapy.

[70]  Steven Taylor,et al.  Role of anxiety sensitivity in pain-related fear and avoidance , 1996, Journal of Behavioral Medicine.

[71]  Daniela Palomba,et al.  Pavlovian conditioning of muscular responses in chronic pain patients: central and peripheral correlates , 2004, Pain.

[72]  M. Bouton Context and behavioral processes in extinction. , 2004, Learning & memory.

[73]  Steven Linton,et al.  Lowering fear-avoidance and enhancing function through exposure in vivo A multiple baseline study across six patients with back pain , 2004, Pain.

[74]  S. Minoshima,et al.  Keeping pain out of mind: the role of the dorsolateral prefrontal cortex in pain modulation. , 2003, Brain : a journal of neurology.

[75]  M. Bouton Context, ambiguity, and unlearning: sources of relapse after behavioral extinction , 2002, Biological Psychiatry.

[76]  H. Flor,et al.  Pavlovian conditioning of opioid and nonopioid pain inhibitory mechanisms in humans , 2002, European journal of pain.

[77]  Daniel C. Krawczyk,et al.  Contributions of the prefrontal cortex to the neural basis of human decision making , 2002, Neuroscience & Biobehavioral Reviews.

[78]  J. Vlaeyen,et al.  The Treatment of Fear of Movement/(Re)injury in Chronic Low Back Pain: Further Evidence on the Effectiveness of Exposure In Vivo , 2002, The Clinical journal of pain.

[79]  S. Mineka,et al.  Fears, phobias, and preparedness: toward an evolved module of fear and fear learning. , 2001, Psychological review.

[80]  M. Reiss,et al.  Zur Untersuchung der motorischen Asymmetrien1 , 2000 .

[81]  I. Tracey,et al.  Cortical Processing of Human Somatic and Visceral Sensation , 1999, The Journal of Neuroscience.

[82]  Geert Crombez,et al.  Pain-related fear is more disabling than pain itself: evidence on the role of pain-related fear in chronic back pain disability , 1999, Pain.

[83]  S. Rachman Neo-conditioning and the classical theory of fear acquisition☆ , 1991 .

[84]  P. Lang,et al.  Fear conditioning, meaning, and belongingness: a selective association analysis. , 1989, Journal of abnormal psychology.