Studies of the interaction of desmethylimipramine with tyramine in man after a single oral dose, and its correlation with plasma concentration.

and clinical studies by different specialists in different countries. Successful instances of co-operation of this type are already available. f Formal and effective recognition by Health Authorities of the results obtained through international co-operation for the approval of new drugs would be of invaluable help in overcoming the present technical difficulties. As a consequence, it would make all co-operative efforts more efficient and productive for drug research, and, ultimately, for the benefit of the patients in all countries. g To further these aims, the formulation of guidelines in general and for specific classes of drugs is judged to be extremely useful, provided that they are agreed upon on an international basis and allow the necessary flexibility, essential in applied as well as in basic research.