Ribozyme speed limits.
暂无分享,去创建一个
Adam Roth | R. Breaker | A. Roth | Shingo Nakamura | G. M. Emilsson | Ronald R Breaker | Shingo Nakamura | Gail Mitchell Emilsson | S. Nakamura | Adam Roth
[1] R. Raines,et al. Limits to Catalysis by Ribonuclease A. , 1995, Bioorganic chemistry.
[2] H. Lönnberg,et al. Kinetics and Mechanisms for the Cleavage and Isomerization of the Phosphodiester Bonds of RNA by Brønsted Acids and Bases. , 1998, Chemical reviews.
[3] N. Walter,et al. The hairpin ribozyme: structure, assembly and catalysis , 1998, Current opinion in chemical biology.
[4] S. Nakano,et al. General acid-base catalysis in the mechanism of a hepatitis delta virus ribozyme. , 2000, Science.
[5] S. Butcher. Structure and function of the small ribozymes. , 2001, Current opinion in structural biology.
[6] J. Gerlt. 1 Mechanistic Principles of Enzyme-catalyzed Cleavage of Phosphodiester Bonds , 1993 .
[7] D. Lilley,et al. Structure, folding and activity of the VS ribozyme: importance of the 2‐3‐6 helical junction , 2001, The EMBO journal.
[8] A. J. Kirby,et al. Enzyme Mechanisms, Models, and Mimics , 1996 .
[9] J. Guthrie. Hydration and dehydration of phosphoric acid derivatives: free energies of formation of the pentacoordinate intermediates for phosphate ester hydrolysis and of monomeric metaphosphate , 1977 .
[10] Ronald R. Breaker,et al. Kinetics of RNA Degradation by Specific Base Catalysis of Transesterification Involving the 2‘-Hydroxyl Group , 1999 .
[11] K. Taira,et al. The Hydrolysis of RNA: From Theoretical Calculations to the Hammerhead Ribozyme-Mediated Cleavage of RNA. , 1998, Chemical reviews.
[12] J. Steitz,et al. A general two-metal-ion mechanism for catalytic RNA. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[13] R R Breaker,et al. Relationship between internucleotide linkage geometry and the stability of RNA. , 1999, RNA.
[14] R. Kuimelis,et al. Cleavage properties of an oligonucleotide containing a bridged internucleotide 5'-phosphorothioate RNA linkage. , 1995, Nucleic acids research.
[15] S. Halford,et al. Nucleases, 2nd Ed , 1993 .
[16] W. Jencks. Catalysis in chemistry and enzymology , 1969 .
[17] R. Breslow. How do imidazole groups catalyze the cleavage of RNA in enzyme models and in enzymes? Evidence from "negative catalysis" , 1991 .
[18] M. Cohn,et al. The Mechanism of the Alkaline Hydrolysis of Ribonucleic Acids , 1954 .
[19] O. Uhlenbeck,et al. Hammerhead ribozyme kinetics. , 1998, RNA.
[20] S. Acharya,et al. The pKa's of 2‘-Hydroxyl Group in Nucleosides and Nucleotides , 2001 .
[21] T. S. Wadkins,et al. Ribozyme activity in the genomic and antigenomic RNA strands of hepatitis delta virus , 2002, Cellular and Molecular Life Sciences CMLS.
[22] R. Breaker,et al. A common speed limit for RNA-cleaving ribozymes and deoxyribozymes. , 2003, RNA.
[23] F. Westheimer. Why nature chose phosphates. , 1987, Science.
[24] T. C. Bruice,et al. One- and Two-Metal Ion Catalysis of the Hydrolysis of Adenosine 3‘-Alkyl Phosphate Esters. Models for One- and Two-Metal Ion Catalysis of RNA Hydrolysis , 1996 .
[25] O. Uhlenbeck,et al. A re-investigation of the thio effect at the hammerhead cleavage site. , 1999, Nucleic acids research.
[26] M. Komiyama,et al. Evidence for the rate-limiting departure of the 5'-oxygen in nonenzymatic and hammerhead ribozyme-catalyzed reactions , 1996 .
[27] G. Tocchini-Valentini,et al. Selection of novel Mg(2+)‐dependent self‐cleaving ribozymes. , 1995, The EMBO journal.
[28] Eric V. Anslyn,et al. Unifying the Current Data on the Mechanism of Cleavage–Transesterification of RNA , 1997 .
[29] A. Ferré-D’Amaré,et al. Direct pK(a) measurement of the active-site cytosine in a genomic hepatitis delta virus ribozyme. , 2001, Journal of the American Chemical Society.
[30] R R Breaker,et al. Examination of the catalytic fitness of the hammerhead ribozyme by in vitro selection. , 1997, RNA.
[31] F. Richards,et al. 24 Bovine Pancreatic Ribonuclease , 1971 .
[32] L. Hansen,et al. Thermodynamics of proton dissociation in dilute aqueous solution. V. An entropy titration study of adenosine, pentoses, hexoses, and related compounds. , 1966, Journal of the American Chemical Society.
[33] R. Collins,et al. Identification of the catalytic subdomain of the VS ribozyme and evidence for remarkable sequence tolerance in the active site loop. , 2002, Journal of molecular biology.
[34] R R Breaker,et al. Structural diversity of self-cleaving ribozymes. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[35] R. Strömberg,et al. Hydrolytic Reactions of the Diastereomeric Phosphoromonothioate Analogs of Uridylyl(3',5')uridine: Kinetics and Mechanisms for Desulfurization, Phosphoester Hydrolysis, and Transesterification to the 2',5'-Isomers , 1995 .
[36] H. Lönnberg,et al. General and specific acid/base catalysis of the hydrolysis and interconversion of ribonucleoside 2′- and 3′-phosphotriesters: kinetics and mechanisms of the reactions of 5′-O-pivaloyluridine 2′- and 3′-dimethylphosphates , 1995 .
[37] W. Scott,et al. Biophysical and biochemical investigations of RNA catalysis in the hammerhead ribozyme , 1999, Quarterly Reviews of Biophysics.
[38] D. Leader,et al. Degradation and modification of nucleic acids , 1986 .
[39] R. Strömberg,et al. Base Catalysis and Leaving Group Dependence in Intramolecular Alcoholysis of Uridine 3‘-(Aryl phosphorothioate)s , 1996 .
[40] W. Kauzmann,et al. The Kinetics of Hydrolysis of Ribonucleic Acid , 1952 .
[41] P. Järvinen,et al. Interconversion and phosphoester hydrolysis of 2',5'- and 3',5'-dinucleoside monophosphates: kinetics and mechanisms , 1991 .
[42] K. Eckart,et al. Synthesis and Properties of Diuridine Phosphate Analogues Containing Thio and Amino Modifications. , 1996, The Journal of organic chemistry.
[43] A. Neilson,et al. Hydrolysis of Esters of Monoribonucleotides , 1956, Nature.
[44] J. Bashkin,et al. Inorganic Mimics of Ribonucleases and Ribozymes: From Random Cleavage to Sequence-Specific Chemistry to Catalytic Antisense Drugs. , 1998, Chemical reviews.
[45] D. Brown,et al. 13. Nucleotides. Part X. Some observations on the structure and chemical behaviour of the nucleic acids , 1952 .
[46] W. Saenger. Physical Properties of Nucleotides: Charge Densities, pK Values, Spectra, and Tautomerism , 1984 .
[47] Ronald R. Breaker,et al. In Vitro Selection of Catalytic Polynucleotides. , 1997, Chemical reviews.
[48] R. Kluger,et al. Mechanism and Catalysis of Nucleophilic Substitution in Phosphate Esters , 1989 .
[49] I. Tinoco,et al. Solution structure of loop A from the hairpin ribozyme from tobacco ringspot virus satellite. , 1996, Biochemistry.
[50] J. Szostak,et al. In vitro selection of functional nucleic acids. , 1999, Annual review of biochemistry.
[51] J. Wedekind,et al. Crystallographic structures of the hammerhead ribozyme: relationship to ribozyme folding and catalysis. , 1998, Annual review of biophysics and biomolecular structure.
[52] M. Fedor,et al. Structure and function of the hairpin ribozyme. , 2000, Journal of molecular biology.
[53] S. Benkovic,et al. 6 Chemical Basis of Biological Phosphoryl Transfer , 1973 .
[54] S. Benkovic,et al. Chemical basis for enzyme catalysis. , 2000, Biochemistry.
[55] Substrate specificity and reaction kinetics of an X-motif ribozyme. , 2003, RNA.
[56] A. Fersht. Structure and mechanism in protein science , 1998 .
[57] D. Herschlag,et al. Mapping the transition state for ATP hydrolysis: implications for enzymatic catalysis. , 1995, Chemistry & biology.
[58] G. F. Joyce,et al. A general purpose RNA-cleaving DNA enzyme. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[59] A. Pardi,et al. Unusual dynamics and pKa shift at the active site of a lead dependent ribozyme , 1997 .
[60] F. Westheimer. Pseudo-rotation in the hydrolysis of phosphate esters , 1968 .