Epilepsy surgery, resection volume and MSI localization in lesional frontal lobe epilepsy

To verify whether interictal noninvasive information detected by magnetoencephalography (MEG) recordings can contribute to localize focal epileptic activity relevant for seizure generation in lesional frontal lobe epilepsy, magnetic source imaging (MSI) localizations of epileptic discharges were compared to the extent of neurosurgical resection and postoperative outcome. Preoperative MEG spike localizations were displayed in postoperative magnetic resonance imaging (MRI) scans to check whether dipole sites were located within the resection cavity. Moreover, MEG localizations were compared with results of prolonged video-EEG monitoring and, in three cases, with invasive EEG recordings. Our results in five cases with lesional frontal lobe epilepsy showed that good surgical outcome could be achieved in those patients where the majority of MEG spike localizations were located within the resected brain volume.

[1]  P. Kotagal,et al.  Lateral Frontal Lobe Seizures , 1998, Epilepsia.

[2]  Takashi Yoshimoto,et al.  Surgical Implications of Neuromagnetic Spike Localization in Temporal Lobe Epilepsy , 2002, Epilepsia.

[3]  Masato Matsuura,et al.  Indication for Anterior Temporal Lobectomy in Patients with Temporal Lobe Epilepsy and Psychopathology , 2000, Epilepsia.

[4]  D. Spencer,et al.  Strategies for reoperation after comprehensive epilepsy surgery. , 2001, Journal of neurosurgery.

[5]  O Ganslandt,et al.  Magnetoencephalography in extratemporal epilepsy. , 2000, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[6]  R Steinmeier,et al.  Functional neuronavigation with magnetoencephalography: outcome in 50 patients with lesions around the motor cortex. , 1999, Neurosurgical focus.

[7]  A M Murro,et al.  Multichannel magnetoencephalography in ablative seizure surgery outside the anteromesial temporal lobe. , 1995, Stereotactic and functional neurosurgery.

[8]  Christoph Baumgartner,et al.  Magnetoencephalography in presurgical epilepsy evaluation , 2002, Neurosurgical Review.

[9]  N Nakasato,et al.  Comparisons of MEG, EEG, and ECoG source localization in neocortical partial epilepsy in humans. , 1994, Electroencephalography and clinical neurophysiology.

[10]  Jerome Engel,et al.  Surgical treatment of the epilepsies , 1993 .

[11]  G Lindinger,et al.  Magnetoencephalography in Focal Epilepsy , 2000, Epilepsia.

[12]  J S Ebersole,et al.  Applications of magnetic source imaging in evaluation of candidates for epilepsy surgery. , 1995, Neuroimaging clinics of North America.

[13]  T. Schwartz,et al.  Standardization of Amygdalohippocampectomy with Intraoperative Magnetic Resonance Imaging: Preliminary Experience , 2002, Epilepsia.

[14]  D W King,et al.  Magnetoencephalography in neocortical epilepsy. , 2000, Advances in neurology.

[15]  C. Nimsky,et al.  Intraoperative Magnetic Resonance Imaging Combined with Neuronavigation: A New Concept , 2001, Neurosurgery.